A5100414148- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Mitochondrial Function and Pathology
- Bacterial Identification and Susceptibility Testing
- Genetics, Aging, and Longevity in Model Organisms
- SARS-CoV-2 and COVID-19 Research
- Metabolism and Genetic Disorders
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Chromatin Remodeling and Cancer
- interferon and immune responses
- Cancer Mechanisms and Therapy
- Streptococcal Infections and Treatments
- Cancer-related molecular mechanisms research
- Geomagnetism and Paleomagnetism Studies
- Toxoplasma gondii Research Studies
- Zoonotic diseases and public health
- Fungal Biology and Applications
- Effects of Environmental Stressors on Livestock
- RNA and protein synthesis mechanisms
- Long-Term Effects of COVID-19
- Rangeland Management and Livestock Ecology
- Yersinia bacterium, plague, ectoparasites research
- Herpesvirus Infections and Treatments
- Reproductive Biology and Fertility
Xuzhou Medical College
2015-2025
The University of Texas Health Science Center at San Antonio
2025
Second Affiliated Hospital of Dalian Medical University
2025
Dalian Medical University
2025
Sun Yat-sen University
2011-2024
Jiading District Central Hospital
2024
Shanghai University of Medicine and Health Sciences
2024
Wuhan Children's Hospital
2020-2024
Huazhong University of Science and Technology
2020-2024
Wuhan Institute of Virology
2024
SARS-CoV-2 Infection in Children In this report, investigators Wuhan, China, describe the spectrum of Covid-19 illness children under age 16 years. Of 1391 assessed and tested...
ABSTRACT Background Since mid-December 2019, a cluster of pneumonia-like diseases caused by novel coronavirus, now designated COVID-19 the WHO, emerged in Wuhan city and rapidly spread throughout China. Here we identify clinical characteristics cohort patients Shanghai. Methods Cases were confirmed real-time RT-PCR analysed for demographic, clinical, laboratory radiological features. Results Of 198 patients, median duration from disease onset to hospital admission was 4 days. The mean age...
Ursolic acid (UA) is a triterpenoid compound with multiple biological functions. This has recently been reported to possess an anti-obesity effect; however, the mechanisms are less understood.As adipogenesis plays critical role in obesity, present study was conducted investigate effect of UA on and action 3T3-L1 preadipocytes.The preadipocytes were induced differentiate presence or absence for 6 days. The cells determined proliferation, differentiation, fat accumulation as well protein...
The SIRT1 deacetylase is one of the best-studied putative mediators some anti-aging effects calorie restriction (CR), but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies displayed a shorter median than wild-type on an ad libitum diet. Here, we report CR heterozygote SIRT1(+/-) was identical (51%) to observed mice, higher frequency certain pathologies. Although larger studies additional genetic backgrounds are needed,...
The constrained outbreak of COVID-19 in Mainland China has recently been regarded as a successful example fighting this highly contagious virus. Both the short period (in about three months) transmission and sub-exponential increase confirmed cases have proved that Chinese authorities took effective epidemic prevention measures, such case isolation, travel restrictions, closing recreational venues, banning public gatherings. These measures can, course, effectively control spread pandemic....
Candidemia is the most common, serious fungal infection and Candida antifungal resistance a challenge. We report recent surveillance of candidemia in China.The study encompassed 77 Chinese hospitals over 3 years. Identification species was by mass spectrometry DNA sequencing. Antifungal susceptibility determined using Clinical Laboratory Standards Institute broth microdilution method.In total, 4010 isolates were collected from patients. Although C. albicans common species, non-albicans...
Melophagus ovinus is considered to be of great veterinary health significance. However, little known about the information on genetic mechanisms specific biological characteristics and novel methods for controlling M. ovinus.
Abstract Global greenhouse gas emission, major factor driving climate change, has been increasing since nineteenth century. STIRPAT and CEVSA models were performed to estimate the carbon emission peaks terrestrial ecosystem sinks at provincial level in China, respectively. Utilizing growth characteristics peak time criteria for period 1997–2019, patterns of energy consumption CO 2 emissions from 30 Chinese provinces are categorized into four groups: (i) one-stage increase (5 provinces), (ii)...
Dengue hemorrhagic fever (DHF)/Dengue shock syndrome (DSS) is a fatal infectious disease that demands an effective treatment. Interferon (IFN)-stimulated genes (ISGs) induced by dengue virus (DENV) exert antiviral effects. Among ISGs, IFN-α inducible gene 6 (IFI6) was increased in DENV infected human umbilical vascular endothelial cells (HUVECs) microarray analysis our previous study. However, its function incompletely understood. In this study, we confirmed IFI6 markedly infection of both...
ABSTRACT Data on the epidemiology of invasive candidiasis (IC) and antifungal susceptibility Candida isolates in China are still limited. Here we report surveillance for IC from Hospital Invasive Fungal Surveillance Net (CHIF-NET) study. Sixty-five tertiary hospitals collected 8,829 1 August 2009 to 31 July 2014. Matrix-assisted laser desorption ionization–time flight mass spectrometry supplemented by ribosomal DNA sequencing was used define species, fluconazole voriconazole susceptibilities...
Candida albicans, which is the most common human fungal pathogen, causes high mortality among immunocompromised patients. Antifungal drug resistance becomes a major challenge for management of infection. Diorcinol D (DD), diphenyl ether derivative isolated from an endolichenic fungus, exerted fungicidal action against species. In this study, we investigated possible mechanism its antifungal activity. The change membrane dynamics and permeability suggested that cell was disrupted by treatment...
OBJECTIVE Various implanted materials are used in neurosurgery; however, there remains a lack of pooled data on infection rates (IRs) and infective bacteria over past decades. The goal this study was to investigate implant infections neurosurgical procedures longitudinal retrospective evaluate the IRs neurosurgically distribution pathogenic microorganisms. METHODS A systematic literature search conducted using PubMed Web Science databases for time period between 1968 2018. Neurosurgical were...
Recurrent outbreaks of the coronavirus disease 2019 (COVID-19) have occurred in many countries around world. We developed a twofold framework this study, which is composed by one novel descriptive model to depict recurrent global COVID-19 and dynamic understand intrinsic mechanisms outbreaks. used publicly available data cumulative infected cases from 1 January 2020 2 2021 30 provinces China 43 other world for validation further analyses. These time series could be well fitted new model....
Abstract Background Population aging has become an escalating issue in China resulting increasing healthcare demand. Smart senior care the potential to help older adults live independently and relieve pressure of including home-based care. This study aimed explore Chinese adults’ preferred access models service content smart factors affecting their willingness choose Methods was a cross-sectional study. A total 760 community-dwelling from Xuzhou, were included this Their demographics, family...
Many studies shown that neurological diseases are associated with neural mitochondrial dysfunctions and microbiome composition alterations. Since mitochondria emerged from bacterial ancestors during endosymbiosis, mitochondria, bacteria had analogous genomic characteristics, similar bioactive compounds comparable energy metabolism pathways. Therefore, it is necessary to rationalize the interactions of intestinal microbiota mitochondria. Recent have identified dysfunction as a critical...
<abstract abstract-type="Summary"> <sec> <b>What is already known about this topic?</b> Pertussis has reemerged as a significant public health threat, primarily due to variations in <i>Bordetella pertussis</i> strains, antimicrobial resistance, and vaccine evasion. </sec><sec> added by report?</b> All isolated strains were identified <i>ptxA1/ptxC2/ptxP3/prn150/fim2-1/fim3-1/fhaB1/tcfA2</i> type exhibited resistance erythromycin. Two showed deficiency Fha, thirty Prn, one strain multiple...
The constantly emerging evidence indicates a close association between coronary artery disease (CAD) and non-alcoholic fatty liver (NAFLD). However, the exact mechanisms underlying their mutual relationship remain undefined. This study aims to explore common signature genes, potential mechanisms, diagnostic markers, therapeutic targets for CAD NAFLD. We downloaded NAFLD datasets from Gene Expression Omnibus (GEO) database analyzed differentially expressed genes (DEGs) by limma....
Although nucleoporin 98 (NUP98) fusion oncogenes often drive aggressive pediatric leukemia by altering chromatin structure and expression of HOX genes, underlying mechanisms remain elusive. Here, we report that a Hoxb-associated lncRNA HoxBlinc was aberrantly activated in NUP98-PHF23 fusion-driven leukemias. occupancies led to elevated MLL1 recruitment aberrant homeotic topologically associated domains (TADs) enhanced accessibilities homeotic/hematopoietic oncogenes. HoxBlinc-depletion NUP98...