A5100381912- Gut microbiota and health
- Immunotherapy and Immune Responses
- interferon and immune responses
- Ion-surface interactions and analysis
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Microbial Community Ecology and Physiology
- Atomic and Molecular Physics
- Hepatitis B Virus Studies
- T-cell and B-cell Immunology
- Genomics and Phylogenetic Studies
- Gastrointestinal motility and disorders
- RNA Interference and Gene Delivery
- Autism Spectrum Disorder Research
- Liver Disease Diagnosis and Treatment
- Signaling Pathways in Disease
- Inflammation biomarkers and pathways
- Nutrition, Genetics, and Disease
- Nanoplatforms for cancer theranostics
- Advanced Materials and Semiconductor Technologies
- Cancer-related molecular mechanisms research
- Bioactive natural compounds
- Apelin-related biomedical research
Xiamen University
1997-2024
Yancheng Third People's Hospital
2022-2024
Nanjing Medical University
2024
Zunyi Medical University
2020-2023
Zhongshan Hospital of Xiamen University
2021-2023
Nanjing University of Chinese Medicine
2023
Xuzhou Medical College
2022
Sun Yat-sen University
2022
Beijing Jishuitan Hospital
2021
Peking University
2021
Alterations in the gut microbiota may influence gastrointestinal (GI) dysbiosis frequently reported individuals with autism spectrum disorder (ASD). In this study, we sequenced bacterial 16S rRNA gene to evaluate changes fecal between 48 children ASD and healthy China. At phylum level, number of Firmicutes, Proteobacteria, Verrucomicrobia decreased ASD, while Bacteroidetes/Firmicutes was significantly higher autistic due enrichment Bacteroidetes. genus amount Bacteroides, Prevotella,...
Gold-based nanostructures with tunable wavelength of localized surface plasmon resonance (LSPR) in the second near-infrared (NIR-II) biowindow receive increasing attention phototheranostics. In view limited progress on NIR-II gold nanostructures, a particular liposome template-guided route is explored to synthesize novel nanoframeworks (AuNFs) large mesopores (≈40 nm) for multimodal imaging along therapeutic robustness. The synthesized AuNFs exhibit strong absorbance region, affording their...
Type 2 diabetes mellitus (T2DM) is a complex disorder comprehensively influenced by genetic and environmental risk, research increasingly has indicated the role of microbial dysbiosis in T2DM pathogenesis. However, studies comparing microbiome characteristics between healthy controls have reported inconsistent results. To further identify describe intestinal flora patients, we performed systematic review meta-analysis stool profiles to discern explore heterogeneity among 7 (600 cases, 543...
Fecal microbiota transplantation (FMT) can induce clinical remission in ulcerative colitis (UC) patients. Enemas, nasoduodenal tubes, and colonoscopies are the most common routes for FMT administration. However, there is a lack of definitive evidence regarding effectiveness capsulized treatment UC In this study, we administered to 22 patients with active assess efficiency determine specific bacteria metabolite factors associated response remission. Our results showed that use was successful...
Many studies shown that neurological diseases are associated with neural mitochondrial dysfunctions and microbiome composition alterations. Since mitochondria emerged from bacterial ancestors during endosymbiosis, mitochondria, bacteria had analogous genomic characteristics, similar bioactive compounds comparable energy metabolism pathways. Therefore, it is necessary to rationalize the interactions of intestinal microbiota mitochondria. Recent have identified dysfunction as a critical...
The Nkrp1 (Klrb1)-Clr (Clec2) genes encode a receptor-ligand system utilized by NK cells as an MHC-independent immunosurveillance strategy for innate immune responses. related Ly49 family of MHC-I receptors displays extreme allelic polymorphism and haplotype plasticity. In contrast, previous BAC-mapping aCGH studies in the mouse suggest neighboring Nkrp1-Clr cluster is evolutionarily stable. To definitively compare relative evolutionary rate vs. gene clusters, clusters from two...
The progression of hepatic fibrosis can lead to cirrhosis and failure, but the development antifibrotic drugs have faced challenges poor effectiveness targeted specificity. Herein, a theranostic strategy was carried encapsulate natural medicine (Quercetin, QR) into hepatitis B core (HBc) protein nanocages (NCs) for imaging treatment fibrosis. It noted that nanoparticles (RGD-HBc/QR) with surface-displayed RGD targeting ligand exhibit rather high selectivity toward activated HSCs via binding...
Tumor cells are rich in antigens, which provide a reliable antigen library for the design of personalized vaccines. However, an effective tumor vaccine vector that can efficiently deliver antigens to lymphoid organs stimulate strong CD8+ cytotoxic T-lymphocyte immune response is still lacking. Here we designed dual-antigen delivery system based on hepatitis B virus core virus-like particles (HBc VLPs). We first confirmed different antigen-loaded HBc VLP monomers could be assembled into...
Tumor immunosurveillance is known to be of critical importance in controlling tumorigenesis and progression various cancers. The role gamma-interferon-inducible lysosomal thiol reductase (GILT) tumor has recently been studied several malignant diseases, but its breast cancer remains elucidated. In the present study, we found GILT as a significant different expressed gene by cDNA microarray analysis. To further determine cancer, examined expression cancers well noncancerous tissues...
The 2019 death of the female Swinhoes soft-shelled turtle (Rafetus swinhoei) individual in China put this species a dire conservation state. To avoid loss genetic information from and facilitate protection preservation R. swinhoei, we sequenced assembled its draft chromosome-level genome by combining BGISEQ short reads, Nanopore long Hi-C sequencing reads. We characterized potential ZZ/ZW sex determination system. Phylogeny divergence time analyses indicated that swinhoei has close...
Non-alcoholic fatty liver disease (NAFLD) is one of the primary causes cirrhosis and a major risk factor for hepatocellular carcinoma liver-related death. It has been correlated with changes in gut microbiota, which promote its development by regulating insulin resistance, bile acid choline metabolism, inflammation. Recent studies suggested controversial role stimulator interferon genes (STING) NAFLD. Here, we showed that as an immune regulator, STING aggravates progression NAFLD...
Protein cages have played a long-standing role in biomedicine applications, especially tumor chemotherapy. Among protein cages, virus like particles (VLPs) received attention for their potential applications vaccine development and targeted drug delivery. However, most of the existing protein-based platform technologies are plagued with immunological problems that may limit systemic delivery efficiency as carriers. Here, we show using immune-orthogonal sequentially modifying dominant loop...
The aim of this study was to reveal the exact changes during occurrence breast cancer explore significant new and promising genes or factors related disease.We compared gene expression profiles tissues with its uninvolved normal as controls using cDNA microarray analysis in seven patients. Further, one representative gene, named IFI30, quantitatively analyzed by real-time PCR confirm result analysis.A total 427 were identified significantly differential expression, 221 up-regulated 206...
Abstract Therapeutic cancer vaccines have the potential to induce regression of established tumors, eradicate microscopic residual lesions, and prevent metastasis recurrence, but their efficacy is limited by low antigenicity soluble antigens immunosuppressive tumor‐associated macrophages (TAMs) that promote tumor growth. In this study, a novel strategy reported for overcoming these defenses: dual‐targeting nano‐vaccine (NV) based on hepatitis B core antigen (HBcAg) derived virus‐like...
Both sulfur polycarbon hydride cations and anions were generated by laser ablating the mixture of carbon powders further investigated experimentally theoretically means collision-induced dissociation ab initio calculations respectively. The computation results agree very well with mass spectrometric in stability connectivity these species. experimental theoretical illustrate that cluster ions is H−C−···−C−S, their alternates number clustering atoms, C−S weakest bond all also reveal opposite...
Background: Although the characteristics of gut microbiota children with autism spectrum disorder (ASD) have been well studied, those young adults ASD seldom reported. Methods: Using 16S rRNA gene sequencing, we characterized 19 and compared them that healthy adults. A random forest prediction model was used to distinguish between two groups at genus level. Results: The abundance levels one phylum, seven families, 18 genera in were significantly different from controls. Phascolarctobacterium...