A5070068556- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Anesthesia and Neurotoxicity Research
- Nanoparticles: synthesis and applications
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Bone Tissue Engineering Materials
- Fullerene Chemistry and Applications
- Autophagy in Disease and Therapy
- biodegradable polymer synthesis and properties
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- ATP Synthase and ATPases Research
- Drug Transport and Resistance Mechanisms
- Food Quality and Safety Studies
- Photodynamic Therapy Research Studies
- Quantum Dots Synthesis And Properties
- Hepatitis B Virus Studies
- Air Quality and Health Impacts
- Electrochemical sensors and biosensors
Xiamen University
2015-2024
Fujian Fisheries Research Institute
2017
Centre for Biomedical Engineering and Physics
2015
First Affiliated Hospital of Xiamen University
2015
Dokkyo University
2003-2004
Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response. Functional nanomaterials offer great potential steady codelivery of various drugs, especially small molecules, peptides, and nucleic acids, thereby realizing controllable drug release, increase bioavailability, reduction adverse effects. Herein, peptide assembling nanoparticle that can sequentially respond dual stimuli in tumor extracellular matrix was designed...
A novel formulation system of phytosomes loaded with mitomycin C-soybean phosphatidylcholine (MMC-SPC) complex (MMC-loaded phytosomes) was prepared by a solvent evaporation method combined nanoprecipitation technique for the purpose development an MMC drug delivery system. The MMC-loaded were evaluated average particle size, zeta-potential, and residual drug-loading content as well in vitro release profile. Furthermore, stability tests vitro/vivo biological evaluations performed. DSC, FTIR,...
In recent years, hepatitis B core protein virus-like particle (HBc VLP) is an impressive biomaterial, which has attracted considerable attention due to favorable properties such as structural stability, high uptake efficiency, and biocompatibility in biomedical applications. Heretofore, only a few attempts have been made apply it physical, chemical, biological therapy for cancer. this study, tumor-targeting RGD-HBc VLP first fabricated through genetic engineering. For image-guided cancer...
“All-in-one” carrier-free-based nano-multi-drug self-delivery system could combine triple advantages of small molecules, nanoscale characteristics, and synergistic combination therapy together. Researches have showed that dual-acting small-molecular methotrexate (MTX) target kill the folate-receptor-overexpressing cancer cells. Inspired by this mechanism, a novel collaborative early-phase tumor-selective targeting late-phase anticancer approach was developed for self-assembly...
Nanoparticles camouflaged by red blood cell (RBC) membranes have attracted considerable attention owing to reservation of structure membrane and surface proteins, endowing prominent cell-specific function including biocompatibility, prolonged circulation lifetime, reduced reticular endothelial system (RES) uptake ability. Considering the drawbacks carrier-free nanomedicine serious drug burst release, poor stability, lack immune escape function, herein we developed fabricated a novel RBC...
This study reports a multifunctional nanoparticle (NP) that can be used for amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) due to its surface coating with polydopamine (PDA) shell. Importantly, by means of introducing the PDA, large quantities water trapped around NPs allowing more efficient exchange, leading greatly improved MR contrast signals compared those from without PDA coating. Further, distinct effect obtained arising strong absorption in near-infrared...
Integrating advantages of mitomycin C (MMC)–phospholipid complex for increased drug encapsulation efficiency and reduced premature release, DSPE-PEG-folate (DSPE-PEG-FA) specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC–phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake intracellular delivery. More importantly,...
Gold nanoparticles enhance TRAIL sensitivity through Drp1-mediated apoptotic and autophagic mitochondrial fission in NSCLC cells Sunkui Ke,1 Tong Zhou,2 Peiyan Yang,3 Yange Wang,2 Peng Zhang,2 Keman Chen,2 Lei Ren,2 Shefang Ye2 1Department of Thoracic Surgery, Zhongshan Hospital Xiamen University, 2Department Biomaterials, College Materials, 3Department First Affiliated Xiamen, People’s Republic China Abstract: Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)...
Abstract: Polyhydroxylated derivatives of fullerene C 60 , named fullerenols (C [OH] n ), have stimulated great interest because their potent antioxidant properties in various chemical and biological systems, which enable them to be used as a new promising pharmaceutical for the future treatment oxidative stress-related diseases, but details remain unknown. Nuclear factor erythroid 2-related 2 (Nrf2) is principal transcription that regulates expression several genes via binding response...
Both folic acid (FA)- and methoxypoly(ethylene glycol) (mPEG)-conjugated chitosan nanoparticles (NPs) had been designed for targeted prolong anticancer drug delivery system. The NPs were prepared with combination of ionic gelation chemical cross-linking method, followed by conjugation both FA mPEG, respectively. FA-mPEG-NPs compared either or mPEG-/FA-NPs in terms their size, targeting cellular efficiency tumor tissue distribution. specificity the mPEG-FA-NPs cancerous cells was demonstrated...
Biomedical applications of carbon nanotubes (CNTs) often involve improving their hydrophilicity and dispersion in biological media by modifying them through noncovalent or covalent functionalization. However, the potential adverse effects surface-functionalized CNTs have not been well characterized. In this study, we functionalized multi-walled (MWCNTs) via carboxylation, to produce MWCNTs-COOH, poly (ethylene glycol) linking, MWCNTs-PEG. We used these MWCNTs study effect surface...
Nanoparticles (NPs) functionalized with targeting ligands have shown promise, but are still limited by their nonspecific uptake certain healthy tissues and cells that express low or even comparable levels of receptors. To increase accumulation at tumor sites while decreasing the unintended toxicity, a possible solution is involvement two separate tumor-specific in localization. In this study, dual tumor-targeting drug-loaded NP system was self-assembled amphiphilic conjugate...
Aim: To explore the therapeutic effect of nanoparticle-based dual-targeting delivery antitumor agents for glioblastoma treatment. Materials & methods: A hepatitis B core protein-virus-like particle (VLP)-based system was designed with primary brain targeting peptide TGN blood–brain barrier penetration and tumor vascular preferred ligand RGD (arginine–glycine–aspartic acid) targeting. Chemo- gene-therapeutic paclitaxel siRNA were co-packaged inside vehicle. Results: The results demonstrated...
The integration of reactive oxygen species (ROS)-based chemodynamic therapy (CDT) and photodynamic (PDT) has attracted enormous attention for synergistic antitumor therapies. However, the strategy is severely hampered by tumor hypoxia overproduced antioxidant glutathione (GSH) in microenvironment. Inspired concept metal coordination-based nanomedicines, we proposed an effective cancer treatment response to special microenvironmental properties. Herein, present novel metal-coordinated...
[This retracts the article DOI: 10.2147/IJN.S129274.].
Recently, the global trend in field of nanomedicine has been toward design combination nature active constituents and phospholipid (PC) to form a therapeutic drug-phospholipid complex. As particular amphiphilic molecular complex, it can be unique bridge traditional dosage-form novel drug delivery system. In thisarticle, on basis complex technique self-assembly technique, we chose pharmacologically safe low toxic curcumin (CUR) increase drug-loading ability, achieve controlled/sustained...
Self-recognizing and stimulus-responsive carrier-free metal-coordinated nanotheranostics with a robust structure could achieve multi-modal imaging-guided synergistic photo-chemotherapy.