A5072401227- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Angiogenesis and VEGF in Cancer
- Axon Guidance and Neuronal Signaling
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Lymphatic System and Diseases
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Animal Genetics and Reproduction
- Endoplasmic Reticulum Stress and Disease
- Radiomics and Machine Learning in Medical Imaging
- Aldose Reductase and Taurine
- Reproductive Biology and Fertility
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- Photoacoustic and Ultrasonic Imaging
- Biosensors and Analytical Detection
- Medical Imaging Techniques and Applications
- Phagocytosis and Immune Regulation
- Liver physiology and pathology
- Heme Oxygenase-1 and Carbon Monoxide
Xiamen University
2016-2025
Sir Run Run Shaw Hospital
2023
Zhejiang University
2023
Shaoxing People's Hospital
2023
Mayo Clinic
2017-2020
WinnMed
2017-2020
Lanzhou University
2020
Inner Mongolia University
2010-2016
Cancer Research Center
2014
We report a simple and rapid method for fabricating surface-enhanced Raman scattering (SERS) substrate, which offers good flexibility, excellent optical transparency, high SERS activity. Specifically, the substrate (AuNPs/PMMA film) was obtained through self-assembly of gold nanoparticles (AuNPs) on newborn poly(methyl methacrylate) (PMMA) template. The UV–vis spectroscopy analysis scanning electron microscopy observation revealed that were closely assembled flexible transparent PMMA...
Multifunctional nanocomposites hold great potential to integrate therapeutic and diagnostic functions into a single nanoscale structure. In this paper, we prepared the MTX-PEG-CS-IONPs-Cy5.5 by functionalizing surface of chitosan-decorated iron oxide nanoparticles (CS-IONPs) with polyethylene glycolated methotraxate (MTX-PEG) near-infrared fluorescent cyanin dye (Cy5.5). A clinically useful PEGylated anticancer prodrug, MTX-PEG, was also developed as tumor cell-specific targeting ligand for...
“All-in-one” carrier-free-based nano-multi-drug self-delivery system could combine triple advantages of small molecules, nanoscale characteristics, and synergistic combination therapy together. Researches have showed that dual-acting small-molecular methotrexate (MTX) target kill the folate-receptor-overexpressing cancer cells. Inspired by this mechanism, a novel collaborative early-phase tumor-selective targeting late-phase anticancer approach was developed for self-assembly...
The lethality and chemotherapy resistance of pancreatic cancer necessitates the urgent development innovative strategies to improve patient outcomes. To address this issue, we designed a novel drug delivery system named GDMCN2,which uses iron-based metal organic framework (Fe-MOF) nanocages encased in covalent (COF) modified with cancer-specific antibody, NRP2. After being targeted into tumor cells, GDMCN2 gradually release sonosensitizer sinoporphyrin sodium (DVDMS) chemotherapeutic...
Locating nanomedicines at the active sites plays a pivotal role in nanoparticle-based cancer therapy field. Herein, multifunctional nanotherapeutic is designed by using graphene oxide (GO) nanosheets with rich carboxyl groups as supporter for hyaluronic acid (HA)–methotrexate (MTX) prodrug modification via an adipicdihydrazide cross-linker, achieving synergistic multistage tumor-targeting and combined chemo-photothermal therapy. As biomaterial, HA can increase affinity of nanocarrier toward...
Fibrosarcoma, a malignant mesenchymal tumor, is characterized by aggressive invasiveness and high recurrence rate, leading to poor prognosis. Anthracycline drugs, such as doxorubicin (DOX), represent the frontline chemotherapy for fibrosarcoma, but often exhibit suboptimal efficacy. Recently, exploiting stimulator of interferon genes (STING)-mediated innate immunity has emerged hopeful strategy cancer treatment. Integrating with immunomodulators in chemo-immunotherapy shown potential...
Embolotherapy is an effective antitumor method, which essentially blocks the oxygen supply and induces hypoxia to treat tumors; however, traditional practices demand high expertise harbor risks of complications. This study presents a mesoporous polydopamine-based (MPDA) drug delivery platform modified by engineered fusion proteins, can specifically embolize tumor blood vessels deliver hypoxia-activated prodrug tirapazamine (TPZ). The protein consists affibody targeting HER-2, substrate for...
High-efficiency nanotheranostic agents with multimodal imaging guidance have attracted considerable interest in the field of cancer therapy. Herein, novel silver-decorated bismuth-based heterostructured polyvinyl pyrrolidone nanoparticles (NPs) good biocompatibility (Bi-Ag@PVP NPs) were synthesized for accurate theranostic treatment, which can integrate computed tomography (CT)/photoacoustic (PA) and photodynamic therapy/photothermal therapy (PDT/PTT) into one platform. The Bi-Ag@PVP NPs...
In the last decade, biosynthesis of metal nanoparticles using organisms have received more and considerations. However, complex composition adds up to a great barrier for characterization biomolecules involved in synthesis process their biological mechanisms.In this research, we biosynthesized kind flower-shaped Au nanoclusters (Au NCs) one definite component-epigallocatechin gallate (EGCG), which was main green tea polyphenols. Possessing good stability 6 weeks size 50 nm, NCs might be...
Neuropilin-1 (NRP-1) is a nontyrosine kinase coreceptor for semaphorin 3A and the vascular endothelial growth factor involved in tumor angiogenesis, growth, metastasis regarded as promising target cancer therapy. In present study, we investigated effects of an anti-NRP-1 monoclonal antibody (mAb) that generated MCF7 breast cellular adhesion studies. MTT, colony formation, assays showed our mAb dose-dependently inhibited proliferation fibronectin adhesion, leading to rounded morphology....
Tumor-targeting combination chemotherapy is an important way to improve the therapeutic index and reduce side effects as compared traditional cancer treatments. However, one of major challenges in surface functionalization nanoparticle (NP) accomplishing multiple purposes through single ligand. Upon such consideration, methotrexate (MTX), anticancer drug with a targeting moiety inspired by similar structure folate, could be used covalently link lipid-polymer conjugate (DSPE-PEG) via...
The particle shape of the drug delivery systems had a strong impact on their in vitro and vivo performance, but there was limited availability techniques to produce specific shaped carriers. In this article, novel methotrexate (MTX) decorated MPEG-PLA nanobacillus (MPEG-PLA-MTX NB) prepared by self-assembly technique followed extrusion through SPG membrane with high N2 pressure for targeted delivery, which Janus-like MTX not only used as anticancer could also be served tumor-targeting...
ABSTRACT Autophagy is considered to be an important switch for facilitating normal malignant cell transformation during colorectal cancer development. Consistent with other reports, we found that the membrane receptor Neuropilin1 (NRP1) greatly upregulated in colon cells underwent autophagy upon glucose deprivation. However, mechanism underlying NRP1 regulation of unknown. We knockdown inhibits and largely upregulates expression aldo-keto reductase family 1 B10 (AKR1B10). Moreover,...
This article reports the effect of Neuropilin-1 monoclonal antibody (NRP-1 MAb) on glioma cell lines in vitro and nude mice bearing tumor (U87) vivo. MTT, scratch test transwell were used to evaluate inhibitory NRP-1 MAb lines. The tissue distribution targeting capability U87 Xenografts was determined Optical Imaging. Anti-glioma experiment carried out by mice. showed inhibit proliferation, migration invasion cells. can specifically target reduce proliferation activity tumor. results this...
Abstract Recently, methotrexate (MTX) has been used to target folate (FA) receptor-overexpressing cancer cells for targeted drug delivery. However, the systematic evaluation of MTX as a Janus-like agent not reported before. Here, we explored validity using playing an early-phase cancer-specific targeting ligand cooperated with late-phase therapeutic anticancer based on PEGylated chitosan (CS) nanoparticles (NPs) carriers. Some advantages these nanoscaled delivery systems are follows: (1) NPs...
Transforming growth factor (TGF-β)-induced activation of quiescent hepatic stellate cells (HSCs) and their transformation to myofibroblasts is a key event in liver fibrosis portal hypertension. GIPC (also referred as synectin) downstream signal molecule TGF-β other receptors. In this study, we sought identify novel genes targeted by elucidate if how they may contribute fibrosis.
Abstract The anti‐tumor efficacy of single photodynamic therapy (PDT) and radiotherapy (RT) has been greatly affected by inadequate tumor uptake photo/radiation sensitizers, limited laser penetration depth, radiation sickness caused high doses X‐rays. Here, the authors report a biomimetic coronavirus‐inspired hollow mesoporous gadolinium/bismuth nanocarrier loaded with new NIR photosensitizer HB (termed as HB@VHMBi‐Gd) for magnetic resonance imaging (MRI)‐guided synergistic photodynamic‐RT....
We detected the expressions of neuropilin-1 (NRP-1) on glioma cell lines and tissues by monoclonal antibody (NRP-1 MAb). The NRP-1 were Western blot, Immunofluorescence staining Immunocytochemistry staining, which indicated that was over-expressed (U251, U87 C6) tissues. MAb prepared successfully could combine specifically to membranes U87, C6). It lays a foundation for further research biological treatment glioma.
Poor drug distribution and inefficient concentrations within the tumor intracellular environment still limit therapeutic efficacy of drugs for cancer chemotherapy. Local delivery (physical targeting) combined with receptor-mediated (chemical assistance by a novel shape design is promising strategy to treat infiltrating (even those that persist post surgery). In this paper, we prepared dye methotrexate (MTX) functionalized nanobacilli (MPEG-PLA-MTX-Cy5.5 NB) self-assembly technique extrusion...
Chlorin e6-C-15-ethyl ester (LS-HB), a newly identified photosensitizer, was isolated from chlorin e6. The mechanism of tumor cell death induced by photodynamic therapy with LS-HB (LS-HB-PDT) is still unknown. Here, we investigated the photophysical properties LS-HB, evaluated antitumor effect on melanoma in vitro and vivo, explored its possible mechanisms. not only has an optimal spectral band red wavelength (660 nm) for photosensitization but also favorable photostability. More...
Abstract The self‐delivery of sonosensitizers and immunomodulators to tumor areas, which is highly recommended for enhancing sonodynamic immunotherapy, remains a challenge. Herein, self‐delivering nanodrug (HB‐NLG8189, drug loading: ≈100 wt%) developed by the small‐molecule self‐assembly "HB" (a new clinical photosensitizer) NLG8189 (indoleamine‐(2,3)‐dioxygenase (IDO) pathway inhibitor) sonodynamic‐augmented immunotherapy; this preparation method ensures absence excipient‐related toxicity...