A5049701833- Adipose Tissue and Metabolism
- Nanoplatforms for cancer theranostics
- Radiation Detection and Scintillator Technologies
- Mitochondrial Function and Pathology
- Photodynamic Therapy Research Studies
- Sirtuins and Resveratrol in Medicine
- Medical Imaging Techniques and Applications
- Muscle Physiology and Disorders
- Genomics, phytochemicals, and oxidative stress
- Kidney Stones and Urolithiasis Treatments
- Digital Radiography and Breast Imaging
- Cardiac Ischemia and Reperfusion
- Chronic Disease Management Strategies
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Pediatric Urology and Nephrology Studies
- Peroxisome Proliferator-Activated Receptors
- Cardiomyopathy and Myosin Studies
- ATP Synthase and ATPases Research
- Autophagy in Disease and Therapy
- Coenzyme Q10 studies and effects
- Circular RNAs in diseases
- Cardiac Fibrosis and Remodeling
- Connective Tissue Growth Factor Research
- Liver Disease Diagnosis and Treatment
Jeonbuk National University
2006-2025
Beijing Glass Research Institute
2024
State Grid Corporation of China (China)
2024
Hunan Normal University
2021-2023
Xiamen University
1993-2023
Mianyang Central Hospital
2023
Shanghai Tenth People's Hospital
2022
Tongji University
2022
Gwangju Institute of Science and Technology
2008-2019
First Affiliated Hospital of Guangzhou Medical University
2014-2017
Quercetin and resveratrol are known to have beneficial effects on the diabetes diabetic complication, however, of combined treatment these compounds not fully revealed. Therefore, present study was designed investigate antidiabetic action quercetin (QE) (RS) in streptozotocin (STZ)-induced rats. To test co-treated with diabetes, serum glucose, insulin, lipid profiles, oxidative stress biomarkers, ions were determined. Additionally, activities hepatic glucose metabolic enzymes histological...
Rationale: SERCA2a, sarco-endoplasmic reticulum Ca 2+ -ATPase, is a critical determinant of cardiac function. Reduced level and activity SERCA2a are major features heart failure. Accordingly, intensive efforts have been made to develop efficient modalities for activation. We showed that the enhanced by post-translational modification with SUMO1 (small ubiquitin-like modifier 1). However, roles other modifications on still unknown. Objective: In this study, we aim assess role lysine...
Growing evidence has indicated that supplementation with probiotics improves lipid metabolism. We aimed to investigate the beneficial effects of a mixture (PM) three strains belonging species Bifidobacterium (B. longum, B. lactis, and breve) two Lactobacillus (L. reuteri L. plantarum) on cholesterol-lowering efficacy in hypercholesterolemic rats. A rat model was established by feeding high-cholesterol diet for eight weeks. To test PM hypercholesterolemia, rats were assigned four groups,...
The lethality and chemotherapy resistance of pancreatic cancer necessitates the urgent development innovative strategies to improve patient outcomes. To address this issue, we designed a novel drug delivery system named GDMCN2,which uses iron-based metal organic framework (Fe-MOF) nanocages encased in covalent (COF) modified with cancer-specific antibody, NRP2. After being targeted into tumor cells, GDMCN2 gradually release sonosensitizer sinoporphyrin sodium (DVDMS) chemotherapeutic...
Notch-1 (Notch) is a cell surface receptor that regulates cell-fate decisions in the developing nervous system, and it may also have roles synaptic plasticity adult brain. Binding of its ligands results proteolytic cleavage Notch by γ-secretase enzyme complex, thereby causing release intracellular domain (NICD) translocates to nucleus, which transcription. Here we show activation modulates ischemic neuronal death vitro vivo. Specifically, our findings from use siRNA or overexpression NICD...
Non-alcoholic fatty liver disease (NAFLD) is a common that causes serious damage. Exercise recognized as non-pharmacological tool to improve the pathology of NAFLD. However, antioxidative effects and mechanisms by which exercise ameliorates NAFLD remain unclear. The present study conducted training on zebrafish during 12-week high-fat feeding period antioxidant effect liver. We found swimming decreased lipid accumulation improved pathological changes in diet-fed zebrafish. Moreover,...
Multiple signaling pathways involving protein kinase C (PKC) have been implicated in the development of cardiac hypertrophy. We observed that a putative PKC inhibitor, PICOT (PKC-Interacting Cousin Of Thioredoxin) was upregulated response to hypertrophic stimuli both vitro and vivo. This suggested may act as an endogenous negative feedback regulator hypertrophy through its ability inhibit activity, which is elevated during Adenovirus-mediated gene transfer completely blocked neonatal rat...
Background/Objectives: The extract from aerial yam bulbils (AYB) contains various bioactive compounds, yet the mechanisms underlying its effects on APAP-induced liver injury need to be investigated further. This study sought pursue of AYB and potential involved in mitigating hepatotoxicity. Methods: TIB-73 cells were pretreated with (10, 20, 40 μg/mL) for 24 h treated APAP induce cytotoxicity. Results: Analysis apoptosis-related proteins revealed that exerts anti-apoptotic inhibiting MAPK...
The use of doxorubicin (Dox) is restricted because its cardiotoxicity, which poses a significant mortality risk for cancer patients, despite being highly effective antibiotic treating various types cancer. Therefore, identifying substances or developing preventive strategies against Dox-induced cardiotoxicity crucial. This study was conducted to determine whether sinapic acid (SA), phenolic compound with range pharmacological effects, could protect in H9c2 cardiomyoblasts. To investigate the...
Although increased levels of myocardial receptor activator nuclear factor (NF)-κB ligand (RANKL) have been reported in heart failure, the role this pathway mediating activation inflammatory pathways during remodelling is less well understood. This study sought to determine RANKL regulating cytokine expression. A marked increase expression occurred as early 6h following transverse aortic constriction (TAC) mouse hearts and persisted at 3 17 days. An tumour necrosis factor-α (TNF-α),...
We studied trends in first-time myocardial infarction (MI) incidence and case fatality after day 28 to examine the role of sex, education as an indicator for socioeconomic position, birth country on these events Sweden. Nationwide cohort including 6,752,655 individuals aged 35–89 years living Sweden between January 1987 December 2008, which, 6,464,968 366,085 nonfatal MI patients were classified according their country, followed over two decades. Main outcome measures: Incidence...
Alternatively spliced tissue factor (asTF) is a novel isoform of full-length factor, which exhibits angiogenic activity. Although asTF has been detected in human plaques, it unknown whether its expression atherosclerosis causes increased neovascularization and an advanced plaque phenotype.Carotid (n=10) coronary (n=8) specimens from patients with stable or unstable angina were classified as complicated uncomplicated on the basis morphology. Analysis cell type-specific revealed strong...
Mulberry is known to have pharmacological effects against cholesterol, obesity, and dyslipidemia. Many studies revealed that mulberry leaf possesses hepatoprotective properties nonalcoholic fatty liver disease (NAFLD); however, fruit less studied in this context. Therefore, study aimed investigate the preventive of high fat diet- (HFD-) induced NAFLD. To evaluate on NAFLD, two doses ethanol extracts [MB, 100, 200 mg/kg BW (body weight)] were given HFD-fed rats for 10 weeks. MB dramatically...
The phytochemical oxyresveratrol has been shown to exert diverse biological activities including prevention of obesity. However, the exact reason underlying anti-obese effects is not fully understood. Here, we investigated and mechanism in adipocytes high-fat diet (HFD)-fed obese mice. Oxyresveratrol suppressed lipid accumulation expression adipocyte markers during differentiation 3T3-L1 C3H10T1/2 cells. Administration HFD-fed mice prevented body-weight gains, lowered adipose tissue weights,...
Obesity is a highly prevalent disease that can induce metabolic syndrome and associated with greater risk of muscular atrophy. Mitochondria play central roles in regulating the physiological metabolism skeletal muscle; however, whether decreased mitochondrial function impaired muscle unclear. In this study, we evaluated effects high-fat diet on zebrafish model sarcopenic obesity (SOB). SOB zebrafish, significant decrease exercise capacity fiber cross-sectional area was detected, accompanied...