A5026649708- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Congenital Heart Disease Studies
- Corneal surgery and disorders
- Muscle Physiology and Disorders
- Spinal Cord Injury Research
- MicroRNA in disease regulation
- Glaucoma and retinal disorders
- Inflammasome and immune disorders
- Mitochondrial Function and Pathology
- Coronary Artery Anomalies
- Retinal Diseases and Treatments
- Childhood Cancer Survivors' Quality of Life
- Congenital heart defects research
- Nutrition and Health in Aging
Changsha Normal University
2025
Hunan Normal University
2022-2025
Type 2 diabetes mellitus (T2DM) is a common metabolic disease that frequently accompanied by multiple complications, including diabetic myopathy, muscle disorder mainly manifested as decreased function and reduced mass. Diabetic myopathy relatively complication among patients with attributed to mitochondrial dysfunction. Therefore, we investigated the mechanisms underlying development, focusing on role of microRNAs (miRs). Zebrafish were fed high-sugar diet for 8 weeks immersed in glucose...
Obesity is a highly prevalent disease that can induce metabolic syndrome and associated with greater risk of muscular atrophy. Mitochondria play central roles in regulating the physiological metabolism skeletal muscle; however, whether decreased mitochondrial function impaired muscle unclear. In this study, we evaluated effects high-fat diet on zebrafish model sarcopenic obesity (SOB). SOB zebrafish, significant decrease exercise capacity fiber cross-sectional area was detected, accompanied...
Congenital heart defects (CHDs) are common human birth defects. Genetic mutations potentially cause the exhibition of various pathological phenotypes associated with CHDs, occurring alone or as part certain syndromes. Zebrafish, a model organism strong molecular conservation similar to humans, is commonly used in studies on cardiovascular diseases owing its advantageous features, such similarity electrophysiology, transparent embryos and larvae for observation, suitability forward reverse...
Excessive alcohol consumption can cause alcoholic myopathy, but the molecular mechanism is still unclear. In this study, zebrafish were exposed to 0.5% for eight weeks investigate effect of on skeletal muscle and its mechanism. The results showed that body length, weight, cross-sectional area fibers, Ucrit, MO2max significantly decreased after exposure. expression markers atrophy autophagy was increased, P62 reduced. content ROS, mRNA sod1 sod2, protein Nox2 increased. addition, we found...