A5024946575- Enzyme Structure and Function
- Biotin and Related Studies
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- Mesoporous Materials and Catalysis
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Polyoxometalates: Synthesis and Applications
- Porphyrin and Phthalocyanine Chemistry
- Enzyme Production and Characterization
- Porphyrin Metabolism and Disorders
- Microbial Metabolic Engineering and Bioproduction
- Protein Structure and Dynamics
- Amino Acid Enzymes and Metabolism
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Polar Research and Ecology
- Glycogen Storage Diseases and Myoclonus
- Biofuel production and bioconversion
- DNA and Nucleic Acid Chemistry
- RNA modifications and cancer
- Calcium signaling and nucleotide metabolism
- Microbial Community Ecology and Physiology
- Carbohydrate Chemistry and Synthesis
- Ubiquitin and proteasome pathways
Tianjin Medical University
2018-2025
Jeonbuk National University
2025
Shanghai Institutes for Biological Sciences
2010-2019
University of Chinese Academy of Sciences
2018-2019
Chinese Academy of Sciences
2004-2018
Shanghai Institute of Nutrition and Health
2018
Institute of Tibetan Plateau Research
2010-2014
Lanzhou University
2014
Columbia University
2006-2012
University of Hong Kong
2010-2011
Isopentenyl pyrophosphate (IPP) is a common precursor for the synthesis of all isoprenoids, which have important functions in living organisms. IPP produced by mevalonate pathway archaea, fungi, and animals. In contrast, synthesized mevalonate-independent most bacteria, algae, plant plastids. 1-Deoxy-d-xylulose 5-phosphate synthase (DXS) catalyzes first rate-limiting step an attractive target development novel antibiotics, antimalarials, herbicides. We report here structural information on...
SBA-15-Fe(terpy)2+ complex efficiently catalyzed oxidative C–C cross-coupling reactions of tertiary amines with carbon nucleophiles in high product yields. The supported terpyridine ligand can be recycled by filtration.
The iron complexes [Fe(qpy)](ClO4)2 (1) (qpy = 2, 2′ : 6′, 2′′ 6′′, 2′′′ 6′′′, 2′′′′-quinquepyridine), [Fe2(spy)2](ClO4)4 (2) (spy 2′′′′: 6′′′′, 2′′′′′-sexipyridine), [Fe2(septipy)2](ClO4)4 (3) (septipy 2′′′′ 2′′′′′ 6′′′′′, 2′′′′′′-septipyridine) and SBA-15-supported terpyridine complex (4) are efficient catalysts for the practical oxidation of alkenes, arenes, alkanes, tertiary amines N-acyl cyclic using Oxone as oxidant. With 1, 3 or 4 catalyst, a variety electron-rich electron-deficient...
The Hippo/Yes-associated protein (YAP) pathway has pivotal roles in innate immune responses against pathogens macrophages. However, the role of YAP macrophages during atherosclerosis and its mechanism activation remain unknown. Here, we find that overexpression myeloid cells aggravates atherosclerotic lesion size infiltration macrophages, whereas deficiency reduces plaque. Tumor necrosis factor receptor-associated 6 (TRAF6), a downstream effector interleukin-1β (IL-1β), triggers...
Atherosclerosis preferentially occurs at specific sites of the vasculature where endothelial cells (ECs) are exposed to disturbed blood flow. Translocation integrin α5 lipid rafts promotes activation and ligation, which is critical for oscillatory shear stress (OSS)-induced EC activation. However, underlying mechanism OSS promoted raft translocation has remained largely unknown.The objective this study was specify mechanotransduction OSS-induced subsequent activation.Mass spectrometry...
Heterogeneous chiral Mn(salen) catalysts axially immobilized on mesoporous materials via phenyl sulfonic groups result in remarkably higher ee values (up to 95%) for asymmetric epoxidation of unfunctionalised olefins.
A heterogeneous version of the Sharpless epoxidation: a chiral tartaric acid derivative is grafted onto surface silica and in mesopores MCM-41 (see picture). The hybrid catalyst as effective homogeneous complex terms turnover number enantioselectivity, product easily separated by simple filtration.
Sulfite oxidase deficiency is a lethal genetic disease that results from defects either in the genes encoding proteins involved molybdenum cofactor biosynthesis or sulfite gene itself. Several point mutations have been identified patients suffering this worldwide. Although detailed biochemical analyses carried out on these mutations, no structural data could be obtained because of problems crystallizing recombinant human and rat oxidases failure to clone chicken gene. We synthesized for de...
Acetyl-CoA carboxylases (ACCs) are crucial metabolic enzymes and attractive targets for drug discovery. Haloxyfop tepraloxydim belong to two distinct classes of commercial herbicides kill sensitive plants by inhibiting the carboxyltransferase (CT) activity ACC. Our earlier structural studies showed that haloxyfop is bound near active site CT domain, at interface its dimer, a large conformational change in dimer required binding. We report here crystal structure 2.3 Å resolution domain yeast...
Abstract Glycogen is a branched glucose polymer and serves as an important energy store. Its debranching critical step in its mobilization. In animals fungi, the 170 kDa glycogen enzyme (GDE) catalyses this reaction. GDE deficiencies humans are associated with severe diseases collectively termed storage disease type III (GSDIII). We report crystal structures of complex oligosaccharides, structure-guided mutagenesis biochemical studies to assess structural observations. These reveal that...
Background/Objectives: The extract from aerial yam bulbils (AYB) contains various bioactive compounds, yet the mechanisms underlying its effects on APAP-induced liver injury need to be investigated further. This study sought pursue of AYB and potential involved in mitigating hepatotoxicity. Methods: TIB-73 cells were pretreated with (10, 20, 40 μg/mL) for 24 h treated APAP induce cytotoxicity. Results: Analysis apoptosis-related proteins revealed that exerts anti-apoptotic inhibiting MAPK...
Men are at higher risk of developing chronic lymphocytic leukemia (CLL) than women. DNA methylation has been shown to play important roles in a number cancers. There differences the pattern between men and In this study, we investigated whether contributes sex-related difference B cell CLL risk. Using HumanMethylation450 BeadChip, profiled genome-wide CD19+ cells from 48 patients (29 female 19 male patients) 28 healthy people (19 women 9 men). We identified 1043 differentially methylated...