A5058517260- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Graphene research and applications
- Surface and Thin Film Phenomena
- Atrial Fibrillation Management and Outcomes
- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- Connexins and lens biology
- Neuroscience and Neuropharmacology Research
- Quantum and electron transport phenomena
- Synthesis and properties of polymers
- 2D Materials and Applications
- Molecular Junctions and Nanostructures
- Organic Light-Emitting Diodes Research
- Phytoestrogen effects and research
- Semiconductor materials and interfaces
- Plant biochemistry and biosynthesis
- Cardiac Fibrosis and Remodeling
- Semiconductor materials and devices
- ATP Synthase and ATPases Research
- Soybean genetics and cultivation
Chungbuk National University
2025
Chungnam National University
2015-2024
National University College
2022
New Generation University College
2022
Seoul National University
2021
Institute of Mathematics
2021
Vietnam Academy of Science and Technology
2021
Hanyang University
2012
Eulji University
2006
Gwangju Institute of Science and Technology
2006
Plakophilin-2 (PKP2) is classically defined as a desmosomal protein. Mutations in PKP2 associate with most cases of gene-positive arrhythmogenic right ventricular cardiomyopathy. A better understanding cardiac biology can help elucidate the mechanisms underlying arrhythmic and cardiomyopathic events consequent to deficiency. Here, we sought capture early molecular/cellular that act nascent arrhythmic/cardiomyopathic substrates.We used multiple imaging, biochemical high-resolution mass...
Several high temperature polyimides, as model polymers with various chain rigidities and orders, were synthesized through the polycondensation of p-phenylene diamine (PDA) five different aromatic dianhydrides [i.e., pyromellitic dianhydride (PMDA), biphenyltetracarboxylic (BPDA), 4,4′-oxydiphthalic anhydride (ODPA), benzophenonetetracarboxylic (BTDA), 4,4′-hexafluoroisopropylidenediphthalic (6F)], investigated in terms structure properties. Both fully rodlike PMDA-PDA ether-linked ODPA-PDA...
Multiple signaling pathways involving protein kinase C (PKC) have been implicated in the development of cardiac hypertrophy. We observed that a putative PKC inhibitor, PICOT (PKC-Interacting Cousin Of Thioredoxin) was upregulated response to hypertrophic stimuli both vitro and vivo. This suggested may act as an endogenous negative feedback regulator hypertrophy through its ability inhibit activity, which is elevated during Adenovirus-mediated gene transfer completely blocked neonatal rat...
Abstract Tartary buckwheat ( Fagopyrum tataricum ) is esteemed as a medicinal crop due to its high nutritional and health value. However, the genetic basis for variations in grain ionome remains inadequately understood. Through genome‐wide association studies (GWAS) on ionome, 52 loci are identified associated with 10 elements undergoing selection. Molecular experiments have shown that variation FtACA13 ’s promoter (an auto‐inhibited Ca 2+ ‐ATPase) accountable sodium concentration salt...
Atrial myocytes have two functionally separate Ca 2+ release sites: those in peripheral sarcoplasmic reticulum (SR) adjacent to the channels of surface membrane and central SR not associated with channels. Recently, we reported on gating these different sites by current. In present study, report spatiotemporal properties focal releases (sparks) occurring spontaneously voltage-clamped rat atrial myocytes, using rapid 2-dimensional (2-D) confocal imaging. Peripheral sparks were similar size...
In atrial myocytes immunocytochemistry has shown two groups of ryanodine receptors (RyRs): those at the periphery colocalized with dihydropyridine (DHPRs) and cell interior not associated DHPRs. The extent to which sets RyRs are controlled by Ca2+ current (I(Ca)) or diffusion remains be determined. Here, using rapid (240 Hz) two-dimensional confocal imaging in rat myocytes, we examine directly role I(Ca) on patterns local focal releases. evoked peripheral release within 1-4 ms, causing a...
The clean removal of a poly(methyl methacrylate) (PMMA) film on graphene has been an essential part the process transferring chemical vapor deposited to specific substrate, influencing quality transferred graphene. Here we demonstrate that PMMA can be achieved by single heat-treatment without treatment was adopted in other methods removal. cleanness confirmed four-point probe measurements, synchrotron radiation x-ray photoemission spectroscopy, optical images, and Raman spectroscopy.
Key points Cardiac myocytes are subjected to fluid shear stress during the cardiac cycle and haemodynamic disturbance. A longitudinally propagating, regenerative Ca 2+ wave is initiated in atrial under stress. Here we determine cellular mechanism for this shear‐induced using two‐dimensional confocal imaging combined with pressurized flow. Our data suggest that triggers through ryanodine receptors via P2Y 1 purinoceptor–phospholipase C‐type 2 inositol 1,4,5‐trisphosphate receptor signal...
Myoblast fusion is an essential step in skeletal muscle development and regeneration. NADPH oxidase 4 (Nox4) regulates cellular processes such as proliferation, differentiation, survival by producing reactive oxygen species (ROS). Insulin-like growth factor 1 induces hypertrophy via Nox4, but its function myoblast remains elusive. Here, we report a ROS-dependent role of Nox4 differentiation. Regenerating fibers after injury cardiotoxin had lower cross-sectional area -knockout (KO) mice than...
Abstract Rice embryo proteins were separated by two‐dimensional gel electrophoresis (2‐DE). A total of 105 spots digested with trypsin and the resultant peptides analyzed matrix assisted laser desorption/ionization‐time flight‐mass spectrometry (MALDI‐TOF‐MS). Raw mass spectra fully‐automatically processed searched selected monoisotopic masses against SWISS‐PROT/TrEMBL NCBInr databases. High quality obtained from 53 spots, which 36 identified including 29 not registered in Fifty percent rice...
Atrial myocytes, lacking t‐tubules, have two functionally separate groups of ryanodine receptors (RyRs): those at the periphery colocalized with dihydropyridine (DHPRs), and cell interior not associated DHPRs. We previously shown that Ca 2+ current ( I )‐gated central release has a fast component is followed by slower delayed rising phase. The mechanisms regulate releases remain poorly understood. highly resistant to dialysed buffers, while slower, completely suppressed such exogenous...
Aging | doi:10.18632/aging.101039. Jeong Yi Choi, Chae Young Hwang, Bora Lee, Seung-Min Jae Bahn, Kwang-Pyo Moonkyung Kang, Yeon-Soo Kim, Sun-Hee Woo, Jae-Young Lim, Eunhee Ki-Sun Kwon
During each contraction and haemodynamic disturbance, cardiac myocytes are subjected to fluid shear stress as a result of blood flow the relative movement sheets myocytes. The present study aimed characterize stress-sensitive membrane current in atrial using whole-cell patch clamp technique, combined with pressurized flow, well pharmacological genetic interventions specific proteins. data obtained suggest that indirectly activates monovalent cation carried by transient receptor potential...
For graphene to be used in semiconductor applications, a 'wide energy gap' of at least 0.5 eV the Dirac must opened without introduction atomic defects. However, such wide gap has not been realized graphene, except cases narrow, chemically terminated nanostructures with inevitable edge Here, we demonstrated that 0.74 eV, which is larger than germanium, could uniform monolayer defects into graphene. The was through adsorption self-assembled twisted sodium nanostrips. Furthermore, reversibly...
Cutting-edge research in the band engineering of nanowires at ultimate fine scale is related to minimum a nanowire-based device. The fundamental issue subnanometre whether angle-resolved photoemission spectroscopy (ARPES) can be used directly measure momentum-resolved electronic structure single wire because difficulty associated with assembling into an ordered array for such measurements. Here, we demonstrated that one-dimensional (1D) confinement electrons, which are transferred from...
A soluble poly(amic acid) precursor solution of fully rod-like poly(p-phenylene pyromellitimide) (PMDA-PDA) was spin cast on silicon substrates, followed by soft bake at 80–185°C and subsequent thermal imidization various conditions over 185–400°C in nitrogen atmosphere to be converted the polyimide films. Residual stress generated interface measured situ during imidization. In addition, imidized films were characterized aspect polymer chain orientation ordering prism coupling X-ray...
We studied the atomic and electronic structures of reconstructed Si(557) surface composed one (111) facet three (112) facets in its single unit cell by using first principles calculations, scanning tunneling microscopy, angle-resolved photoemission spectroscopy. A variety structure models were introduced to understand overall properties surface. Among considered, an adatom-parallel dimer model with a missing same bonding network as...
This study examines whether fluid pressure (FP) modulates the L-type Ca 2+ channel in cardiomyocytes and investigates underlying cellular mechanism(s) involved. A flow of pressurized (∼16 dyn/cm 2 ) fluid, identical to that bathing myocytes, was applied onto single rat ventricular myocytes using a microperfusion method. The current ( I cytosolic signals were measured whole cell patch-clamp confocal imaging, respectively. It found FP reversibly suppressed (by 25%) without altering...
Endothelin-1 (ET-1) and the α<Sub>1</Sub>-adrenoceptor agonist phenylephrine (PE) activate cAMP response element binding protein (CREB), a transcription factor implicated in cardiac hypertrophy. The signaling pathway involved CREB activation by these hypertrophic stimuli is poorly understood. We examined pathways for ET-1- or PE-induced activation.Western blotting was performed with pharmacological genetic interventions rat ventricular myocytes.ET-1 PE increased phosphorylation, which...