A5050666299- Food Quality and Safety Studies
- Ginseng Biological Effects and Applications
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Bone Metabolism and Diseases
- Ion channel regulation and function
- NF-κB Signaling Pathways
- Nutrition, Health and Food Behavior
- Pharmacological Effects of Natural Compounds
- Nutritional Studies and Diet
- Diet and metabolism studies
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Fungal Biology and Applications
- Nitric Oxide and Endothelin Effects
- Phytoestrogen effects and research
- Traditional Chinese Medicine Analysis
- Genomics, phytochemicals, and oxidative stress
- Diet, Metabolism, and Disease
- Phytochemicals and Antioxidant Activities
- Biochemical effects in animals
- Phytochemistry and biological activities of Ficus species
- Herbal Medicine Research Studies
- Gastrointestinal motility and disorders
- Neurological Disease Mechanisms and Treatments
Jeonbuk National University
2016-2025
Chonbuk National University Hospital
2016-2025
Dongguk University Ilsan Hospital
2023
Hy-Line (United States)
2008
Wonkwang University
2000-2006
Seoul National University
2006
Chonnam National University
2001
Woosuk University
2000
Korea Institute for Curriculum and Evaluation
1998
Cardiovascular Institute Hospital
1997
Early intervention using dietary supplements may be effective in alleviating cognitive impairment among individuals with mild (MCI). This study investigated the efficacy and safety of Lactobacillus plantarum C29-fermented soybean (DW2009) as a nutritional supplement for enhancement. One hundred MCI were randomly assigned to take DW2009 (800 mg/day, n = 50) or placebo 12 weeks. The primary outcome measure was change composite score functions related memory attention, measured by computerized...
Vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang1) are potent vasculogenic angiogenic factors that hold promise as a means to produce therapeutic vascularization angiogenesis. However, VEGF also acts proinflammatory cytokine by inducing adhesion molecules bind leukocytes cells, an initial essential step toward inflammation. In the present study, we used human umbilical vascular cells (HUVECs) examine effect of Ang1 on VEGF-induced expression three molecules: intercellular...
Abstract —Angiopoietin-1 (Ang1) is a strong inducer of endothelial cell sprouting, which first step in both angiogenesis and neovascularization. We examined the mechanisms underlying Ang1-induced sprouting using porcine pulmonary artery cells. Ang1 induced nondirectional directional migration cells mediated through Tie2 but not Tie1 receptor. tyrosine phosphorylation p125 FAK , this was dependent on phosphatidylinositol (PI) 3′-kinase activity. secretion plasmin matrix metalloproteinase-2...
Progesterone-induced calcium ion (Ca2+) signals in the neck region of sperm play a pivotal role promoting motility. Here, we show that long-lasting Ca2+ signal required for motility response to progesterone depends on their pH-dependent fusion with prostasomes, which are small vesicles secreted by prostate. We found prostasome led transfer receptors, cyclic adenosine diphosphoribose (cADPR)-synthesizing enzymes, ryanodine receptors (RyRs), and other signaling tools from prostasomes neck....
Yerba Mate, derived from the leaves of tree, Ilex paraguariensis, is widely-used as a tea or an ingredient in formulated foods. The aim present study was to evaluate effects Mate extract on weight loss, obesity-related biochemical parameters, and diabetes high-fat diet-fed mice.To this end, by using vivo animal models dietary-induced obesity, we have made interesting observations that has ability decrease differentiation pre-adipocytes reduce accumulation lipids adipocytes, both which...
The Bax inhibitor-1 (BI-1) is an anti-apoptotic protein that located in endoplasmic reticulum (ER) membranes and protects cells from ER stress-induced apoptosis. associated with generation of reactive oxygen species (ROS) through oxidative folding. This study examined the role BI-1 regulation accumulation ROS expression unfolded response-associated proteins. reduced levels glucose response 78, C/EBP homologous protein, phospho-eukaryotic initiation factor 2alpha, IRE1alpha, XBP-1,...
In this study, Bax inhibitor-1 (BI-1) overexpression reduces the ER pool of Ca2+ released by thapsigargin. Cells overexpressing BI-1 also showed lower intracellular release induced ionophore ionomycin as well agonists ryanodine receptors and inositol trisphosphate receptors. contrast, cells expressing carboxyl-terminal deleted (CΔ-BI-1 cells) displayed normal mobilization. Basal rates from were higher in BI-1-overexpressing than control or CΔ-BI-1 cells. We determined that cytosolic region...
This study investigated the molecular mechanism by which Bax inhibitor 1 (BI1) abrogates accumulation of reactive oxygen species (ROS) in endoplasmic reticulum (ER). Electron uncoupling between NADPH-dependent cytochrome P450 reductase (NPR) and 2E1 (P450 2E1) is a major source ROS on ER membrane. stress produced lipid peroxidation membrane, but BI1 reduced this accumulation. Under stress, expression control cells was upregulated more than BI1-overexpressing cells. In cells, inhibiting...
Obesity is a major health problem. A food field research that has recently aroused considerable interest the potential of natural products to counteract obesity. Yerba Mate may be helpful in reducing body weight and fat. The aim this study was investigate efficacy safety supplementation Korean subjects with randomized, double-blind, placebo-controlled trial conducted. Subjects obesity (body mass index (BMI) ≥ 25 but < 35 kg/m2 waist-hip ratio (WHR) 0.90 for men 0.85 women) were given oral...
Red ginseng is prepared by steaming raw ginseng, a process believed to increase the pharmacological efficacy. Further bioconversion of red through fermentation known its intestinal absorption and bioactivity, diminishes toxicity ginseng's metabolite. This study was conducted investigate effects daily supplementation with fermented (FRG) on glycemic status in subjects impaired fasting glucose or type 2 diabetes. four-week long, randomized, double-blind, placebo-controlled trial. Forty-two...
Endothelial dysfunction is one of the main age-related arterial phenotypes responsible for cardiovascular disease (CVD) in older adults. This endothelial results from decreased bioavailability nitric oxide (NO) arising downstream oxidative stress. In this study, we investigated protective effect anthocyanins and underlying mechanism rat thoracic aorta human vascular cells aging models. vitro, cyanidin-3-rutinoside (C-3-R) cyanidin-3-glucoside (C-3-G) inhibited d-galactose (d-gal)-induced...
The purpose of this study was to examine the direct effects propofol on ischemia-reperfusion injury using an isolated Langendorff rat heart preparation. Hearts were perfused with Krebs-Henseleit (K-H) solution (control); intralipid; or 10, 30, and 100 microM propofol. rendered globally ischemic for 25 min, then reperfusion begun K-H 30 min. Treatment delayed onset contracture during ischemia compared control intralipid treatments (6.4 +/- 2.1 vs 4.4 1.4 4.1 0.7 respectively; P < 0.05)....
Effects of norepinephrine and Ca+ on Na(+)-K+ pump pacemaker current were investigated by simultaneous measurement intracellular Na+ activity (aiNa) membrane potential in driven (1 Hz) quiescent sheep cardiac Purkinje fibers. Concurrently, twitch force was measured fibers, which (NE) produced a decrease aiNa, prolongation action duration, hyperpolarization diastolic potential, Vdm. In contrast, NE an increase aiNa depolarization resting Vm. The Vdm blocked 5 x 10(-6) M strophanthidin,...
Inflammation or hypoxia in gingival tissue can induce endoplasmic reticulum (ER) stress, which is related with autophagy. The autophagy a catabolic process involving the degradation of cell's own components. Although resulting total destruction cell one death types, no conclusive evidence exists for such process. In order to examine association ER stress and system, agents brefeldin A, thapsigargin, tunicamycin were exposed human cells. induced expression proteins, glucose-regulated protein...
The prevalence of metabolic syndrome, hypertension, and diabetes has been increasing rapidly in Korea. rate increase paralleled the replacement Korean traditional diets (KTD), which emphasize vegetables fermented foods, with western style dietary patterns that are rich animal foods saturated fat. We aimed to investigate efficacy KTD controlling fasting plasma glucose, blood pressure, cardiovascular disease risk factors hypertensive type 2 diabetic (T2D) patients. Forty-one patients (61.8±1.5...
Health benefits of Kochujang (KCJ) and its bioactive compounds have been reported in several vitro animal studies.The aim this study was to investigate the efficacy KCJ supplementation on body composition blood lipid profiles overweight adults.Sixty men women with BMI ≥23 kg/m2 waist-hip-ratio (WHR) ≥0.90 for ≥0.85 were randomly assigned a supplement (n=30, 32 g/day) or placebo group 12-week, double-blind, controlled study. We measured anthropometric parameters, serum profiles, abdominal fat...
We examined the antiobesity and antioxidant effects of supplementation with doenjang, a fermented soybean paste, in overweight Koreans PPAR-γ2 C1431T polymorphism. Sixty subjects were randomly assigned to consume either 9.8 g/day doenjang or placebo for 12 weeks. Before after intervention, anthropometric metabolic parameters, along abdominal fat distribution polymorphisms, measured. Fifty-one completed study, (n=26) (n=25) groups. Relative frequencies genotypes CC, TC, TT 70% (n=41), 25.9%...