A5036277956- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Cellular Mechanics and Interactions
- Prostate Cancer Treatment and Research
- AI in cancer detection
- Advanced Radiotherapy Techniques
- Artificial Intelligence in Healthcare and Education
- Lung Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Urinary Bladder and Prostate Research
- Force Microscopy Techniques and Applications
- Medical Imaging Techniques and Applications
- 3D Printing in Biomedical Research
- Topic Modeling
- Statistical Methods in Clinical Trials
- Medical Imaging and Analysis
- Muscle and Compartmental Disorders
- Obstructive Sleep Apnea Research
- Genital Health and Disease
- Biomedical Text Mining and Ontologies
- Sexual function and dysfunction studies
- Statistical Methods and Inference
- Meta-analysis and systematic reviews
- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
University of Washington
2020-2025
Samsung (South Korea)
2024
Albert Einstein College of Medicine
2023
Merck & Co., Inc., Rahway, NJ, USA (United States)
2022
University of Washington Medical Center
2021
Montefiore Medical Center
2021
University of Rochester Medical Center
2017-2020
University of Rochester
2017-2018
Guangzhou Medical University
2018
Carnegie Mellon University
2010-2015
Progesterone-induced calcium ion (Ca2+) signals in the neck region of sperm play a pivotal role promoting motility. Here, we show that long-lasting Ca2+ signal required for motility response to progesterone depends on their pH-dependent fusion with prostasomes, which are small vesicles secreted by prostate. We found prostasome led transfer receptors, cyclic adenosine diphosphoribose (cADPR)-synthesizing enzymes, ryanodine receptors (RyRs), and other signaling tools from prostasomes neck....
Background The coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality worldwide. Knowledge about the pathophysiology of its effect on multiple systems is growing. Kidney injury been a topic focus, rhabdomyolysis suspected to be one contributing mechanisms. However, information in patients affected by COVID-19 limited. We aim describe incidence, clinical characteristics, outcomes hospitalized with who developed rhabdomyolysis. Materials methods A...
Pembrolizumab is approved for treating patients with unresectable or metastatic solid tumors high tumor mutational burden (TMB), as assessed by the Food and Drug Administration–approved companion diagnostic FoundationOneCDx, after progression on prior treatment. To expand TMB assessment enriching response to pembrolizumab, measurement from TruSight Oncology 500 (TSO500) was evaluated in archival pan-tumor samples 294 enrolled eight pembrolizumab monotherapy studies. TSO500 a panel-based...
Phagocytosis is a crucial event in the immune system that allows cells to engulf and eliminate pathogens. This mediated through action of immunoglobulin (IgG)-opsonized microbes acting on Fcγ receptors (FcγR) macrophages, which results sustained levels intracellular Ca2+ mobilization second messengers. It known ADP-ribosyl cyclase responsible for rise after FcγR activation. However, it unclear whether how CD38 involved FcγR-mediated phagocytosis. Here we show recruited forming phagosomes...
Cells are complex, dynamic systems that actively adapt to various stimuli including mechanical alterations. Central understanding cellular response stimulation is the organization of cytoskeleton and its actin filament network. In this manuscript, we present a minimalistic network Monte Carlo based approach model under cyclic stretching. Utilizing coarse-grained model, prescribed within two-dimensional circular space through nodal connections. When cyclically stretched, demonstrates...
The protein kinase Mec1 (ATR ortholog) and its partner Ddc2 (ATRIP play a key role in DNA damage checkpoint responses budding yeast. Previous studies have established the model which Ddc1, subunit of clamp, Dpb11, related to TopBP1, activate directly control at G1 G2/M. In this study, we show that contributes activation through Ddc1- or Dpb11-independent mechanism. catalytic activity increases after Ddc2-dependent manner. contrast, occurs even absence Ddc1 Dpb11 function recruits sites...
The Wi-Fi 7 standard (IEEE 802.11be) was developed to meet the growing need for increased capacity and high throughput. However, new, more demanding requirements RF/analog circuits, including an extended bandwidth of 320MHz with 4K-QAM, result in complexity circuit design address issues linearity, noise, bandwidth, power consumption. Despite these challenges, promises faster reliable wireless connectivity. This paper presents a transceiver that demonstrates excellent linearity smallest...
OBJECTIVE To examine patient characteristics, prostate specific antigen (PSA) levels, and established preoperative pathological prognostic factors to determine differences between Caucasian African‐American patients with localised cancer, as it remains controversial whether men present more aggressive disease. PATIENTS AND METHODS One hundred consecutive (aged 53–76 years) undergoing radical retropubic prostatectomy (RRP) at an equal‐access tertiary‐care centre were retrospectively reviewed....
Abstract. Tear and blood urea nitrogen, creatinine, glucose levels were quantitatively analyzed by an enzymatic method in 30 normal patients 10 with end stage renal disease. The tear samples collected from the before after hemodialysis showed that change nitrogen creatinine tears correlated creatinine. may serve as alternative, less invasive indicator of serum metabolites patients.
Abstract Mechanotransduction has been divided into mechanotransmission, mechanosensing and mechanoresponse, although how a cell performs all three functions using the same set of structural components is still highly debated. Here, we bridge gap between emerging molecular systems-level understandings mechanotransduction through multiscale model linking these phases. Our incorporates discrete network actin filaments associated proteins that responds to stretching geometric relaxation. We...
Abstract Drop breakup mechanisms inside a cavity flow are presented for two immiscible fluids. Due to the nonuniform condition of cavity, mechanism varied along streamlines. The streamlines were characterized by stream zones A and B, where zone possessed methodical transient governed Tomotika's via capillary instabilities, B consisted tip streaming breakup, an inefficient mechanism. behavior near flight region had significant role in drop mechanisms. study evolution dispersion showed that...