A5102009739- Sexual function and dysfunction studies
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Pelvic floor disorders treatments
- Sperm and Testicular Function
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Sexual Differentiation and Disorders
- Sexuality, Behavior, and Technology
- Genital Health and Disease
- Pharmacology and Obesity Treatment
- Pharmacological Effects of Natural Compounds
- Plant-derived Lignans Synthesis and Bioactivity
- Urinary Tract Infections Management
- Pain Mechanisms and Treatments
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Marriage and Sexual Relationships
- Urologic and reproductive health conditions
- Healthcare and Venom Research
- Male Reproductive Health Studies
- Nitric Oxide and Endothelin Effects
- Plant Toxicity and Pharmacological Properties
- Anesthesia and Pain Management
- Reconstructive Surgery and Microvascular Techniques
Jeonbuk National University
2012-2021
Chonbuk National University Hospital
2012-2021
Jeonju University
2010-2019
Hanyang University
2002-2016
Peking University First Hospital
2016
Peking University
2016
Sungkyunkwan University
2016
Kyungsung University
2016
Renal Research Institute
2012
Ministry of Education
2006
Progesterone-induced calcium ion (Ca2+) signals in the neck region of sperm play a pivotal role promoting motility. Here, we show that long-lasting Ca2+ signal required for motility response to progesterone depends on their pH-dependent fusion with prostasomes, which are small vesicles secreted by prostate. We found prostasome led transfer receptors, cyclic adenosine diphosphoribose (cADPR)-synthesizing enzymes, ryanodine receptors (RyRs), and other signaling tools from prostasomes neck....
Cisplatin (CIS) is used in the treatment of cancer, but its nonspecific systemic actions lead to toxic effects on other parts body. This study investigated severity CIS toxicity by increasing dose over a constant time period. Sprague Dawley rats were divided into five groups and control group with (2, 4, 6, 8, 10 mg/kg) administered intraperitoneally for 5 days. The body organs weighed, epididymal sperm was counted, motility apoptosis evaluated. Blood samples evaluated complete blood count,...
Abstract Background Monotropein, astragalin, and spiraeoside (MAS) are active compounds extracted from medicinal herbs; monotropein Morinda officinalis How (Rubiaceae), astragalin (kaempferol 3-O-glucoside) Cuscuta chinensis Lamark (Convolvulaceae) the outer scales of Allium cepa L. (Liliceae) in a ratio 6.69:0.41:3.61. well-known antioxidants, anti-inflammatory, antinociceptive agents. The current investigation aims to study molecular mechanism varicocele-induced male infertility underlying...
Schisandrachinensis Baillon (SC) has been utilized for its antioxidants and anti-inflammatory activities in a broad variety of medical applications. However; SC uses improving fertility males related disorders with proper scientific validation remain obscure. The present study aimed to investigate the effects on varicocele (VC)-induced testicular dysfunction potential molecular mechanism associated VC-induced germ cell apoptosis. male Sprague-Dawley rats were equally divided into four groups...
To investigate the presence of C-type natriuretic peptide 1-22 (CNP)-dependent guanylyl cyclase (GC)-coupled receptor and its biological function in penile erectile smooth muscle.Experiments have been done rabbit rat to detect cyclic GMP (cGMP) generation by activation particulate GC peptides (NPs) cavernosal membrane, localize precise using a quantitative vitro autoradiography snap frozen sections, define (NPR) mRNA reverse transcriptase-polymerase chain reaction (RT-PCR) technique monitor...
Korean ginseng and mountain (Panax CA Meyer) are important traditional herbal plants whose ginsenosides generally accepted as serving to improve sexual functions, such penile erection.We investigated the effects of tissue-cultured extract (TMGE) on male patients with erectile dysfunction (ED).A double-blind, placebo-controlled study was conducted 143 experiencing ED.Over course 8 weeks, one group took 1 000 mg TMGE twice a day, other placebo day.The were analyzed using version International...
Study Type – Therapy (RCT) Level of Evidence 1b What's known on the subject? and What does study add? Avanafil is a potent selective phosphodiesterase type 5 (PDE5) inhibitor newly developed for treating erectile dysfunction (ED). Preclinical clinical phase I studies showed that avanafil had enhanced selectivity, faster onset action favourable side‐effect profile relative to currently available PDE5 inhibitors. As result III trial efficacy safety treatment (100 200 mg), taken as needed over...
Significance In natural matings, semen delivers spermatozoa and immunoregulatory fluids to the female reproductive tract. Here, a soluble form of CD38 (sCD38) is shown play an important role in facilitating maternal immune tolerance against fetus by inducing development uterine tolerogenic DCs forkhead box P3 + (Foxp3 ) regulatory T cells. Deficiency sCD38 seminal fluid increased rates loss allogeneic fetuses, this was rescued direct injection recombinant into uterus. Thus, acts as pivotal...
To elucidate the changes that occur in blood-testis barrier during varicocele we examined Cldn11 (claudin-11), an element of barrier, as well steroidogenesis and proinflammatory cytokines a model rat testes.Male rats with experimentally induced were sacrificed 4 weeks after operation. Testicular histology blood testosterone concentrations examined. The expression tight junctions, steroidogenic enzymes, apoptosis immune cell markers, testes evaluated by reverse transcriptase-polymerase chain...
DA-9401 was prepared as a mixture of Chinese medicinal herb extracts from roots Morinda officinalis How (Rubiaceae), outer scales Allium cepa L. (Liliceae) and seeds Cuscuta chinensis Lamark (Convolvulaceae). The present study designed to investigate the possible protective role in adriamycin (ADR)-induced testicular toxicity associated with oxidative stress, endoplasmic reticulum (ER) apoptosis.Fifty healthy 8-week-old male Sprague-Dawley rats were equally divided into five groups. first...
No AccessJournal of UrologyInvestigative Urology1 Aug 1997Renin Angiotensin System in Rabbit Corpus Cavernosum: Functional Characterization II Receptors Jong Kwan Park, Sung Zoo Kim, Suhn Hee Young Kyung and Woo Cho ParkJong Park , KimSung Kim KimSuhn ParkYoung ChoKyung View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64577-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The...
Objectives: Assess the efficacy and safety of once‐daily tadalafil or tamsulosin versus placebo during 12 weeks on lower urinary tract symptoms (LUTS) in Korean men with benign prostatic hyperplasia (BPH). Methods: Following a 4‐week run‐in period, 151 were randomly assigned to receive 5 mg, 0.2 for weeks. Results: The International Prostate Symptom Score (IPSS) least squares mean changes from baseline endpoint numerically but not significantly improved (−5.8) (−5.4) groups compared (−4.2, P...
Summary Onion ( Allium cepa L.) and quercetin protect against oxidative damage have positive effects on multiple functional parameters of spermatozoa, including viability motility. However, the associated underlying mechanisms action not yet been identified. The aim this study was to investigate effect onion peel extract OPE ) voltage‐gated proton (Hv1) channels, which play a critical role in rapid extrusion. This process underlies wide range physiological processes, particularly male...
Cisplatin causes male infertility but the exact mechanism have not been clarified, yet. MOTILIPERM has implicated in alleviation of Sprague-Dawley rats caused by cisplatin. We evaluated recovery effect on cisplatin (CIS)-induced testicular toxicity rats.Five groups were included. The are control (CTR), CTR + 200 mg/kg/day per oral, CIS 10 mg/kg i.v., 100 mg/kg/day, mg/kg/day. i.v. single dose was given before mg/kg, or oral daily for 28 days. Body and genital organs weight, epididymis sperm...
Context: MOTILIPERM was prepared as a mixture of extracts three medicinal herbs [roots Morinda officinalis How (Rubiaceae), outer scales Allium cepa L. (Liliaceae) and seeds Cuscuta chinensis Lamark (Convolvulaceae)].Objective: To investigate the role reactive oxygen species (ROS)-based endoplasmic reticulum (ER) stress in rat model varicocele therapeutic efficacy this model.Materials methods: Sixty male rats were divided into five experimental groups: normal control group (CTR + vehicle),...
Study Type – Therapy (RCT) Level of Evidence 1b What’s known on the subject? and What does study add? Phosphodiesterase type 5 inhibitors (PDE 5Is) improve erectile function lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH), however exact effects prostate tissue its underlying mechanisms remain unclear. PDE 5Is enhanced production cyclic nucleotides in plasma prostate, distribution was higher than plasma. OBJECTIVE • To evaluate impact a single...
In this study, we aimed to investigate the prevalence and perception of premature ejaculation (PE) in young middle-aged Korean men.The study was conducted using an Internet-assisted questionnaire.A total 2 037 male adults, aged 20 years or older, were randomly sampled based on age residency.The questionnaire developed by PE Study Group Andrological Society includes four categories (overall sexual function, symptoms, distress treatment) with a 16 questions.For each question, symptoms...
Objective: To determine the chemical composition of surgical smoke produced during transurethral resection prostate (TURP) and vaporization. Methods: A total 12 samples were collected from a continuous irrigation suction drainage system to Tenax absorber at 0.05 L/min flow rate TURP The gases quantitatively qualitatively analyzed by gas chromatography‐mass spectrometry (GC‐MS) equipped with purge trap sample injector. Results: main constituents vaporization include propylene, allene,...