A5100317765- Adipose Tissue and Metabolism
- Natural product bioactivities and synthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Phytochemistry and Biological Activities
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Protein Hydrolysis and Bioactive Peptides
- Vestibular and auditory disorders
- Phytochemicals and Antioxidant Activities
- Seaweed-derived Bioactive Compounds
- Food Quality and Safety Studies
- Diet and metabolism studies
- Pharmacological Effects of Natural Compounds
- Peroxisome Proliferator-Activated Receptors
- Plant biochemistry and biosynthesis
- Celiac Disease Research and Management
- Cardiovascular Disease and Adiposity
- Ion Channels and Receptors
- Antioxidant Activity and Oxidative Stress
- Bioactive natural compounds
- Influenza Virus Research Studies
- Biochemical effects in animals
- Oral microbiology and periodontitis research
- Axon Guidance and Neuronal Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
Seoul National University
2008-2024
Korea Food Research Institute
2024
Korea University of Science and Technology
2024
Dongseo University
2024
Hanyang University
2024
Sungkyunkwan University
2012-2023
Kyungpook National University Hospital
2023
Animal and Plant Quarantine Agency
2023
Kyung Hee University
2014-2022
University of Ulsan
2022
Abstract Brown adipose tissue (BAT) plays a central role in regulating energy homeostasis and may provide novel strategies for the treatment of human obesity. BAT-mediated thermogenesis is regulated by mitochondrial uncoupling protein 1 (UCP1) classical brown ectopic beige adipocytes controlled sympathetic nervous system (SNS). Previous work indicated that fish oil intake reduces fat accumulation induces UCP1 expression BAT; however, detailed mechanism this effect remains unclear. In study,...
Uncoupling protein (UCP)-1 expressed in brown adipose tissue plays an important role thermogenesis. Recent data suggest that brown-like adipocytes white (WAT) and skeletal muscle play a crucial the regulation of body weight. Understanding mechanism underlying increase UCP-1 expression level these organs should, therefore, provide approach to managing obesity. The thyroid hormone (TH) has profound effects on mitochondrial biogenesis promotes mRNA UCP tissue. However, action TH induction WAT...
Background and Purpose— To elucidate the mechanisms prognosis of rotational vertebral artery occlusion (RVAO). Methods— We analyzed clinical radiological characteristics, patterns induced nystagmus, outcome in 21 patients (13 men, aged 29–77 years) with RVAO documented by dynamic cerebral angiography during an 8-year period at 3 University Hospitals Korea. The follow-up periods ranged from 5 to 91 months (median, 37.5 months). Most (n=19; 90.5%) received conservative treatments. Results— All...
Lipin1 expression was induced at a late stage of differentiation 3T3-L1 preadipocytes and maintained high levels in mature adipocytes. Knockdown lipin1 by small interfering RNA almost completely inhibited into adipocytes, whereas overexpression accelerated adipocyte differentiation, demonstrating that is required for differentiation. In transfection lipin1-small decreased the functional genes, indicating involvement maintenance function. increases transcription-activating function peroxisome...
Gut microbiota can regulate the host energy metabolism; however, underlying mechanisms that could involve gut microbiota-derived compounds remain to be understood. Therefore, in this study, we investigated effects of KetoA [10-oxo-12(Z)-octadecenoic acid]-a linoleic acid metabolite produced by lactic bacteria-on whole-body metabolism and found dietary intake enhance expenditure mice, thereby protecting mice from diet-induced obesity. By using Ca2+ imaging whole-cell patch-clamp methods, was...
Abstract Adipose tissue (AT) adapts to overnutrition in a complex process, wherein specialized immune cells remove and replace dysfunctional stressed adipocytes with new fat cells. Among recruited AT, lipid-associated macrophages (LAMs) have emerged as key players obesity diseases involving lipid stress inflammation. Here, we show that LAMs selectively express transmembrane 4 L six family member 19 (TM4SF19), lysosomal protein represses acidification through its interaction Vacuolar-ATPase....
Ubiquilin 1 (UBQLN1) is a ubiquitin-like protein, which has been shown to play central role in regulating the proteasomal degradation of various proteins, including presenilins. We recently reported that DNA variants UBQLN1 increase risk for Alzheimer disease, by influencing expression this gene brain. Here we present first assessment effects on metabolism amyloid precursor protein (APP). For purpose, employed RNA interference down-regulate variety neuronal and non-neuronal cell lines....
Obesity causes excess fat accumulation in white adipose tissues (WAT) and also other insulin-responsive organs such as the skeletal muscle, increasing risk for insulin resistance, which can lead to obesity-related metabolic disorders. Peroxisome proliferator-activated receptor-α (PPARα) is a master regulator of fatty acid oxidation whose activator known improve hyperlipidemia. However, molecular mechanisms underlying PPARα activator-mediated reduction adiposity improvement disorders are...
Schisandrachinensis Baillon (SC) has been utilized for its antioxidants and anti-inflammatory activities in a broad variety of medical applications. However; SC uses improving fertility males related disorders with proper scientific validation remain obscure. The present study aimed to investigate the effects on varicocele (VC)-induced testicular dysfunction potential molecular mechanism associated VC-induced germ cell apoptosis. male Sprague-Dawley rats were equally divided into four groups...
Curcumin is a major diarylheptanoid component of Curcuma longa with traditional usage for anxiety and depression. It has been known the anti-inflammatory, antistress, neurotropic effects. Here we examined curcumin effect in neural plasticity cell viability. 60-channel multielectrode array was applied on organotypic hippocampal slice cultures (OHSCs) to monitor 10 μ M long-term depression (LTD) through low-frequency stimulation (LFS) Schaffer collaterals commissural pathways. Cell viability...
The mevalonate pathway is essential for the synthesis of isoprenoids and cholesterol. Adipose tissue known as a major site cholesterol storage; however, role local its synthesized remains unclear. In this study, adipose-specific pathway-disrupted (aKO) mice were generated through knockout 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase (HMGCR). aKO showed serious lipodystrophy accompanied with glucose lipid metabolic disorders hepatomegaly. These variations in dramatically reversed after...
Dopamine-releasing neurons of the substantia nigra pars compacta produce an extraordinarily dense and expansive plexus innervation in striatum converging with glutamatergic corticostriatal thalamostriatal axon terminals at dendritic spines medium spiny neurons. Here, we investigated whether signaling promotes arborization growth dopaminergic axons. In postnatal ventral midbrain cultures, axons rapidly responded to glutamate stimulation accelerated cone splitting when NMDA AMPA/kainate...
Abstract Kaempferia parviflora (KP) is a member of the ginger family and known in Thailand as Thai ginseng, Krachai Dam or Black Ginger. The K. extract (KPE) was previously reported to have number physiological effects; however, antiobesity effects KPE its mechanisms remain be elucidated. In this study, we conducted feeding experiments (low dose: 0.5% KPE, high 1.0% KPE) mice examine effects. For both 7 weeks’ contained high‐fat diet (HFD) significantly decreased body weight gain,...
Background and purpose The inferior cerebellar peduncle ( ICP ) contains various fibres to from the cerebellum relating integration of proprioceptive vestibular functions. However, full clinical features isolated unilateral lesions have not been defined in humans. Methods Eight consecutive patients with at pontine level (six stroke, one multiple sclerosis brainstem encephalitis) received bedside neurological neuro‐otological evaluations underwent laboratory tests including measurements...
Dizziness/vertigo is a common symptom of posterior circulation stroke and usually accompanies other neurologic symptoms signs. Although strokes involving the brainstem or cerebellum may produce isolated vestibular syndrome (isolated vertigo imbalance), overall frequency involved structures in remain uncertain. Isolated occurs approximately 25% patients with stroke, mostly involves cerebellum, inferior superior cerebellar peduncles, caudal lateral rostral dorsolateral medulla. The occasional...
Problem The anti‐inflammatory impact of three polyunsaturated fatty acids (3‐ PUFA ) in endometriosis is incompletely understood. effect 3‐ on endometriosis‐like lesions evaluated as a potential treatment target. Method Study Wild Type ( WT and transgenic Fat‐1 mice (high levels endogenous were utilized uterine tissue transplant model. Experimental donor × host pairs included: WW ), WF FF ). Cytokine content IL ‐1β, ‐2, ‐4, ‐6, ‐10, ‐12, ‐17A, IFN ‐γ, TNF MCP ‐1 RANTES immunocellular...
We present HapticDrone, a concept to generate controllable and comparable force feedback for direct haptic interaction with drone. As proof-of-concept study this paper focuses on creating only in 1D direction. To end, an encountered-type, safe un-tethered display is implemented. An overview of the system details how control output drones provided. Our current prototype generates forces up 1.53 N upwards 2.97 downwards. This serves as first step towards introducing mainstream devices.
ABSTRACT Macrophage-derived nitric oxide (NO·) is a crucial effector against invading pathogens. Yet, paradoxically, several bacterial species, including some pathogens, are known to endogenously produce NO· via synthase (NOS) activity, despite its apparent cytotoxicity. Here, we reveal conserved role for NOS in activating aerobic respiration. We demonstrate that nitrite generated from endogenous decomposition stimulates quinol oxidase activity Staphylococcus aureus and increases the rate of...
Generalized cerebral ischaemia from cardiovascular dysfunction usually leads to presyncopal dizziness, but several studies reported a higher frequency of rotatory vertigo in patients. Whether generalized due disorders may produce objective vestibular was investigated.Thirty-three patients with orthostatic dizziness/vertigo profound hypotension and 30 controls were recruited. All participants underwent recording eye movements during two challenging tests: the Schellong squatting-standing...