A5089281256- Pain Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Ion Channels and Receptors
- Herpesvirus Infections and Treatments
- Sirtuins and Resveratrol in Medicine
- Botulinum Toxin and Related Neurological Disorders
- Neuroendocrine regulation and behavior
- Cancer Treatment and Pharmacology
- PARP inhibition in cancer therapy
- Healthcare and Venom Research
- Neurobiology and Insect Physiology Research
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Circadian rhythm and melatonin
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Pain Management and Treatment
- Neuropeptides and Animal Physiology
- BRCA gene mutations in cancer
- Thermoregulation and physiological responses
- Biochemical effects in animals
- Antioxidant Activity and Oxidative Stress
- Advanced Breast Cancer Therapies
- RNA modifications and cancer
- Peripheral Nerve Disorders
Union Hospital
2020-2024
Shenzhen University Health Science Center
2018-2024
Huazhong University of Science and Technology
2020-2024
Shenzhen University
2017-2024
Southern Medical University
2024
ShenZhen People’s Hospital
2022
Guangdong Medical College
2019-2022
Chongqing Medical University
2020
Xuzhou Medical College
2020
National Clinical Research Center for Digestive Diseases
2020
Objective: Oxytocin (OT) is synthesized within the paraventricular nucleus and supraoptic of hypothalamus. In addition to its role in uterine contraction, OT plays an important antinociceptive role; however, underlying molecular mechanisms remain elusive. We hypothesized that effect on neuropathic pain may occur via inhibition TRPV1 activation spinal cord. The present study explores pain. Methods: Partial sciatic nerve ligation (pSNL) was performed induce Animal behaviors were measured using...
Chemotherapy-induced peripheral neuropathy (CIPN) is the most common side-effect of anti-cancer therapy. To date, there are no clinically effective analgesics that could prevent and treat CIPN. However, exact pathogenesis CIPN still unclear. In present study, we use paclitaxel-induced (PIPN) model, aiming to better understand transcriptomic level Dorsal root ganglia (DRG) neurons in rats with PIPN. mRNA from each DRG sample was reverse transcribed cDNA sequenced using next-generation high...
AIM:To investigate whether nicotinamide overload plays a role in type 2 diabetes. METHODS:Nicotinamide metabolic patterns of 14 diabetic and non-diabetic subjects were compared using HPLC.Cumulative effects N 1 -methylnicotinamide on glucose metabolism, plasma H2O2 levels tissue adenine dinucleotide (NAD) contents adult Sprague-Dawley rats observed.The human sweat glands rat skin metabolism was investigated sauna burn injury, respectively.
Ecological evidence suggests that niacin (nicotinamide and nicotinic acid) fortification may be involved in the increased prevalence of obesity type 2 diabetes, both which are associated with insulin resistance epigenetic changes. The purpose present study was to investigate nicotinamide-induced metabolic changes their relationship possible Male rats (5 weeks old) were fed a basal diet (control group) or diets supplemented 1 4 g/kg nicotinamide for 8 weeks. Low-dose exposure weight gain, but...
Beige adipocytes are a new type of recruitable brownish adipocytes, with highly mitochondrial membrane uncoupling protein 1 expression and thermogenesis. were found among white especially in subcutaneous adipose tissue (sWAT). Therefore, beige may be involved the regulation energy metabolism fat deposition. Transient receptor potential melastatin 8 (TRPM8), Ca2+-permeable non-selective cation channel, plays vital roles various cellular functions. It has been reported that TRPM8 activation...
The global increased prevalence of obesity and diabetes occurred after the worldwide spread B-vitamins fortification, in which whether long-term exposure to high level B vitamins plays a role is unknown. Our aim was examine relationships between consumption prevalence.This population based ecological study conducted possible associations macronutrients US using per capita data from Economic Research Service Centers for Disease Control Prevention.The prevalences adult were highly correlated...
Human cytomegalovirus (HCMV) infects a large portion of the human population globally. Several HCMV-derived noncoding RNAs are involved in regulation viral gene expression and virus life cycle. Here, we reported that circRNAs new class HCMV transcripts. We bioinformatically predict 704 candidate encoded by TB40/E strain 230 HAN strain. also systematically compare circRNA features, including breakpoint sequence consensus, strand preference, length distribution, exon numbers between host...
Abstract Herpetic‐related neuralgia (HN) caused by varicella‐zoster virus (VZV) infection is one of the most typical and common neuropathic pain in clinic. However, potential mechanisms therapeutic approaches for prevention treatment HN are still unclear. This study aims to provide a comprehensive understanding molecular targets HN. We used an HSV‐1 infection‐induced mouse model screened differentially expressed genes (DEGs) DRG spinal cord using RNAseq technique. Moreover, bioinformatics...
Chemotherapy-induced neuropathic pain (CINP) currently has limited effective treatment. Although the roles of oxytocin (OXT) and receptor (OXTR) in central analgesia have been well documented, expression function OXTR peripheral nervous system remain unclear. Here, we evaluated antinociceptive profiles CINP.Paclitaxel (PTX) was used to establish CINP. Quantitative real-time polymerase chain reaction (qRT-PCR), situ hybridization, immunohistochemistry were observe dorsal root ganglia (DRG)....
Background: Obesity is characterized by increased adipose tissue mass that results from fat cell size (hypertrophy) and number (hyperplasia). The molecular mechanisms govern the regulation differentiation of adipocytes play a critical role for better understanding pathological mechanism obesity. However, adipocyte still unclear. Objective: present study aims to compare gene expression changes during in transcriptomic level, which may help understand differentiation. Methods: RNA sequencing...
As a typical neuropathic pain, post-herpetic neuralgia (PHN) is common complication of herpes zoster (HZ), which seriously affects the normal life and work patients. The unclear pathogenesis lack effective drugs make clinical efficacy PHN unsatisfactory. Here, we obtained transcriptome profile neuroblastoma cells (SH-SY5Y) DRG in rats infected with varicella virus (VZV) by sequencing (RNA-Seq) combined publicly available gene array data sets. Next, processing map was analyzed using...
Short-term spinal cord stimulation (st-SCS) has been widely used to treat herpetic-related neuralgia (HN) in China for several years, but is still heavily debated as it no strong evidence clinical application. Therefore, a questionnaire survey among the Chinese pain specialist workgroup of Neuromodulation Society and Medical Doctor Association was carried out achieve consensus about use st-SCS HN treatment.The contents include basic information doctors (hospital level, work experience,...
BRCA mutations are the main known hereditary factors for ovarian cancer. Notably, emerging evidence has led to considerable interest in role of sirtuin 1 (SIRT1) cancer development. However, dynamic crosstalk between BRCA1 and SIRT1 is poorly understood. Here, we showed that: (i) inactivation events (mutation, promoter methylation, or knockdown) were accompanied by decreased levels increased nicotinamide adenine dinucleotide (NAD) a subsequent increase activity; (ii) overexpression resulted...
BRCA mutations are the main known hereditary factor for breast cancer. Notably, poly (ADP-ribose) polymerase 1 (PARP1) expression status plays a critical role in cancer progression and clinical development of PARP1 inhibitors to treat BRCA-mutated has advanced rapidly. However, dynamic crosstalk between BRCA1 remains largely unknown. Here, we showed that: (i) inactivation events (mutation, promoter methylation, or knockdown) were accompanied by increased nicotinamide adenine dinucleotide...
Both hereditary factors (e.g., BRCA1) and nicotinamide adenine dinucleotide (NAD)-dependent metabolic pathways are implicated in the initiation progression of ovarian cancer. However, whether crosstalk exists between BRCA1 NAD metabolism remains largely unknown. Here, we showed that: (i) inactivation events (mutation promoter methylation) were accompanied by elevated levels NAD; (ii) knockdown or overexpression was an effective way to induce increase decrease phosphoribosyltransferase...