A5101608895- Genomics and Phylogenetic Studies
- Ubiquitin and proteasome pathways
- Genetic diversity and population structure
- Protein Degradation and Inhibitors
- Identification and Quantification in Food
- Ziziphus Jujuba Studies and Applications
- Marine Biology and Ecology Research
- Circular RNAs in diseases
- Fermentation and Sensory Analysis
- Herpesvirus Infections and Treatments
- Food Quality and Safety Studies
- Autophagy in Disease and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Curcumin's Biomedical Applications
- Eosinophilic Disorders and Syndromes
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Soft tissue tumor case studies
- Bioactive Compounds and Antitumor Agents
- Drug-Induced Hepatotoxicity and Protection
- Endoplasmic Reticulum Stress and Disease
- Inflammatory Myopathies and Dermatomyositis
- Immune cells in cancer
- Hippo pathway signaling and YAP/TAZ
Chengdu University of Traditional Chinese Medicine
2024
Jinan University
2022-2024
Nanfang Hospital
2022-2024
Shenzhen Center for Disease Control and Prevention
2023
Southern Medical University
2019-2022
Fujian Fisheries Research Institute
2019
Harbin Medical University
2018
Third Affiliated Hospital of Harbin Medical University
2018
University of Algarve
2012
Huazhong Agricultural University
2011-2012
Background Blunt snout bream (Megalobrama amblycephala) is an herbivorous freshwater fish species native to China and has been recognized as a main aquaculture in the Chinese polyculture system with high economic value. Right now, only limited EST resources were available for M. amblycephala. Recent advances large-scale RNA sequencing provide fast, cost-effective, reliable approach generate large expression datasets functional genomic analysis, which especially suitable non-model...
Diosmetin, a natural occurring flavonoid, is primarily found in citrus fruits, beans, and other plants. Diosmetin demonstrates variety of pharmacological activities, including anticancer, antioxidant, anti-inflammatory, antibacterial, metabolic regulation, cardiovascular function improvement, estrogenic effects, others. The process literature search was done using PubMed, Web Science ClinicalTrials databases with terms containing content, activity, pharmacokinetics, vivo, vitro. aim this...
Human cytomegalovirus (HCMV) infects a large portion of the human population globally. Several HCMV-derived noncoding RNAs are involved in regulation viral gene expression and virus life cycle. Here, we reported that circRNAs new class HCMV transcripts. We bioinformatically predict 704 candidate encoded by TB40/E strain 230 HAN strain. also systematically compare circRNA features, including breakpoint sequence consensus, strand preference, length distribution, exon numbers between host...
Inducing immunogenic cell death (ICD) is a promising strategy for cancer immunotherapy. Shikonin (SHK), naphthoquinone compound from Lithospermum erythrorhizon, can stimulate antitumor immunity by inducing ICD. Nevertheless, the immunogenicity of tumor cells killed SHK weak. Endoplasmic reticulum (ER) stress an important intracellular pathway ICD effect. Curcumin (CUR) directly induce ER disrupting Ca2+ homeostasis, which might enhance SHK-induced A self-delivery effect nanobooster (CS-PEG...
In this study, 23 genomic microsatellite DNA markers and 17 express sequence tag (EST)-derived microsatellites were developed characterized using the fast isolation by AFLP of sequences containing repeats (FIASCO) method data mining from public EST databases mandarin fish (Siniperca chuatsi). These polymorphic then tested for polymorphism in a wild S. chuatsi population. The number alleles at SSRs varied 2 to 19 with an average 8.0 per locus. observed expected heterozygosities 0.746 0.711,...
Influenza virus has the ability to circumvent host innate immune system through regulating certain factors for its effective propagation. However, detailed mechanism is still not fully understood. Here, we report that a sphingolipid metabolism-related factor, sphingosine kinase 2 (SPHK2), upregulated during influenza A (IAV) infection, promotes IAV infection in an enzymatic independent manner. The enhancement of replication abolished catalytic-incompetent SPHK2 (G212E) overexpressing cells....
The tumor suppressor gene BRCA1 associated protein-1 (BAP1) is frequently mutated in renal cell carcinoma (RCC). BAP1 loss-of-function mutations are with poor survival outcomes. However, personalized therapy for BAP1-mutated RCC currently not available. Previously, we found that loss renders cells more sensitive to bromodomain and extra-terminal (BET) inhibitors, as demonstrated both culture xenografted nude mice models. Here, demonstrate murine enhances sensitivity BET inhibitors ectopic...
Pond smelt Hypomesus olidus is a small-sized economic species of freshwater fish with delicious meat and high output. In this study, the complete mitochondrial genome H. sequenced to be 16,786 bp in length, including 13 protein-coding genes, 2 ribosomal RNAs, 22 transfer RNAs control region. The overall base composition 24.3% for A, 27.3% T, 29.2% C 19.2% G, slight A + T bias. mitogenome sequence data may provide useful information population genetics analysis elucidation evolutionary...
To explore whether bortezomib and a Bcl-2 inhibitor exhibit synergistic anti-tumor effect in human acute T lymphoblastic leukemia cells.MTT assay was used to determine the cytotoxicity of absence or presence inhibitors (obatoclax, AT-101 ABT-199) Jurkat cells. The effects drug treatment on expression family proteins, LC3B, p62, ubiquitin, BiP/Grp78, p-JNK, p-p38 CHOP proteins were examined by Western blotting. Flow cytometry cell apoptosis. Quantitative real-time PCR measure mRNA levels key...
To study the inhibitory effect of docetaxel (DOC), oxaliplatin (OXA) and their combination on proliferation cervical cancer line HeLa. Cell morphological changes were observed by inverted phase contrast microscope, cell inhibition rates in different groups examined MTT, cycle apoptosis determined flow cytometry (FCM). DOC OXA inhibited HeLa a dose-dependent, two drugs had an enhanced effect; rate was also significantly increased when used combination. can synergistically inhibit HeLa, which...
One of the factors limiting survival rate patients with lung cancer is high risk for recurrence following surgical resection. Previous studies indicate that 14-3-3ζ a central cellular hub protein regulates multiple signaling pathways involved in progression. The present study evaluated prognostic significance adenocarcinoma. expression and E-cadherin, an important epithelial-mesenchymal transition, was by immunohistochemistry tumor tissues adjacent normal resected from 123 correlation...
The traditional polymerase chain reaction method was employed to obtain the complete mitochondrial genome of Andinoacara rivulatus from Lizigu farm, Tianjin city, China. mitogenome determined be 16,585 bp in length. It contains 13 protein-coding genes, 2 rRNAs and 22 tRNAs. sequence structure non-coding control region also analyzed. This is first report on A. rivulatus.