A5053730462- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Herpesvirus Infections and Treatments
- Immune Response and Inflammation
- RNA modifications and cancer
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Pain Mechanisms and Treatments
- Bacterial Identification and Susceptibility Testing
- Genomics and Phylogenetic Studies
- Immune responses and vaccinations
- Plant Virus Research Studies
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Bacterial biofilms and quorum sensing
- Pharmacological Effects of Natural Compounds
- Antibiotics Pharmacokinetics and Efficacy
- Yersinia bacterium, plague, ectoparasites research
- Antimicrobial Resistance in Staphylococcus
University Medical Center Hamburg-Eppendorf
2016-2024
Universität Hamburg
2016-2024
Union Hospital
2020-2024
Zhejiang University
2024
Huazhong University of Science and Technology
2020-2024
Institute of Medical Microbiology and Hygiene
2023
Shenzhen University Health Science Center
2019-2023
Nanjing Agricultural University
2023
Guangdong Medical College
2019-2022
Affiliated Hospital of Jiangsu University
2022
Th17 cells are most abundant in the gut, where their presence depends on intestinal microbiota. Here, we examined whether contribute to extra-intestinal responses autoimmune kidney disease. We found high frequencies of kidneys patients with antineutrophil cytoplasmatic antibody (ANCA)-associated glomerulonephritis. utilized photoconversion Kaede mice track T cell mobilization upon glomerulonephritis induction, and that egress from gut a S1P-receptor-1-dependent fashion subsequently migrate...
Avibactam is a novel broad-range β-lactamase inhibitor active against Ambler class A (including ESBL and KPC) some C D (e.g. OXA-48) enzymes. We here report on the emergence of ceftazidime/avibactam resistance in clinical, multiresistant, OXA-48 CTX-M-14-producing Klebsiella pneumoniae isolate DT12 during treatment.Comparative whole-genome sequence analysis identified two SNPs CTX-M-14-encoding gene leading to amino acid changes (P170S T264I). Compared with WT CTX-M-14, expression...
During mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric (MMc) in the offspring is mostly unknown. Here we show a mouse model which MMc numbers either normal or low, enables assessment MMc. We report promoting fetal development. induces preferential differentiation hematopoietic stem bone marrow towards monocytes within myeloid compartment. Neonatal mice with higher and enhanced resilience against...
S . epidermidis is a substantial component of the human skin microbiota, but also one major causes nosocomial infection in context implanted medical devices. We here aimed to advance understanding genotypes and phenotypes conducive establishment. Furthermore, we investigate adaptation individual clonal lines lifestyle based on detailed analysis populations 23 patients suffering from prosthetic joint infection. Analysis invasive colonizing provided evidence that are characterized by...
Abstract Respiratory syncytial virus (RSV) is a common cause of acute lower respiratory tract infection in infants, older adults and the immunocompromised. Effective directly acting antivirals are not yet available for clinical use. To address this, we screen ReFRAME drug-repurposing library consisting 12,000 small molecules against RSV. We identify 21 primary candidates including RSV F N protein inhibitors, five HSP90 four IMPDH inhibitors. select lonafarnib, licensed farnesyltransferase...
Metagenomic sequencing is increasingly being used in clinical settings for difficult to diagnose cases. The performance of viral metagenomic protocols relies a large extent on the bioinformatic analysis. In this study, European Society Clinical Virology (ESCV) Network NGS (ENNGS) initiated benchmark pipelines currently virological laboratories.Metagenomic datasets from 13 samples patients with encephalitis or respiratory infections characterized by PCR were selected. analyzed different...
Dysbiosis¸ i.e. changes in microbial composition at a mucosal interface, is implicated the pathogenesis of many chronic inflammatory and autoimmune diseases. To assess upper respiratory tract (URT) community patients with granulomatosis polyangiitis (GPA), we used culture-independent high-throughput methods. In this prospective clinical study, nasal swabs were collected from GPA, rheumatoid arthritis (RA, disease control), healthy controls. Nasal bacterial taxa assessed using V3–V4 region...
For herpes simplex virus 1 (HSV-1) the skin is primary site of infection. After lytic infection, enters peripheral nervous system where it establishes latency. Spontaneous reactivation from latently infected neurons leads to typical HSV-1-induced diseases like cold sores. Modelling pathologies challenging due variety different cell types and structures in human-specific responses Nevertheless, studies using monolayer lines, raft cultures, ex vivo mouse models provided an immense contribution...
Abstract Despite the advent of whole genome metagenomics, targeted approaches (such as 16S rRNA gene amplicon sequencing) continue to be valuable for determining microbial composition samples. Amplicon microbiome sequencing can performed on clinical samples from a normally sterile site determine aetiology an infection (usually single pathogen identification) or more complex niches such human mucosa environmental where multiple microorganisms need identified. The methodologies are frequently...
N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), and 7-methylguanosine (m7G) are the major forms of RNA methylation modifications, which closely associated with development many tumors. However, prognostic value methylation-related long non-coding RNAs (lncRNAs) in colon cancer (CC) has not been defined. This study summarised 50 m6A/m1A/m5C/m7G-related genes downloaded 41 normal 471 CC tumor samples RNA-seq data clinicopathological information from The Cancer...
Ultrasonic-assisted extraction technique was used to extract phenolic compounds from Phyllanthus urinaria and response surface methodology optimize the parameters including ultrasonic time (X1), ethanol concentration (X2) solid-liquid ratio (X3). A mathematical model of tree for high yield (Y) established. Antioxidant activity investigated by DPPH free radicals, ABTS hydroxyl radicals reducing power assay with vitamin C as a control. The results showed that independent variables (X1, X2 X3)...
Here, we describe the complete genome sequence of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain isolated from an oropharyngeal swab sample female patient with COVID-19 who was infected in Hamburg, northern Germany.
Opportunistic infections emerging from human skin microbiota are of ever-increasing importance. Cutibacterium acnes , being abundant on the skin, may cause deep-seated (e.g., device-associated infections). Differentiation between invasive (i.e., clinically significant) C. isolates and sole contaminants is often difficult.
The multifunctional Yersinia effector YopM inhibits triggered immunity and increases production of the anti-inflammatory cytokine Interleukin-10 (IL-10) to suppress host immune response. Previously it was shown that induces IL-10 gene expression by elevating phosphorylation serine-threonine kinase RSK1 in nucleus human macrophages. Using transcriptomics, we found strongly affects genes belonging JAK-STAT signaling pathway. Further analysis revealed mediates nuclear translocation...
Objective: Neuroimaging studies on neuropathic pain have discovered abnormalities in brain structure and function. However, the pattern changes from herpes zoster (HZ) to postherpetic neuralgia (PHN) remain unclear. The present study aimed compare activity between HZ PHN patients explore potential neural mechanisms underlying cognitive impairment patients. Methods: Resting-state functional magnetic resonance imaging (MRI) was carried out among 28 right-handed patients, 24 20 healthy controls...
Vancomycin-resistant Enterococcus faecium and faecalis (VRE) are a common cause of healthcare-associated infections. Whole genome sequencing-based typing methods yield the highest discriminatory power for outbreak surveillance in hospital. We analysed clonal composition enteric VRE populations at-risk patients over several weeks to characterise population diversity dynamics.Five bone marrow transplant recipients (three colonised with vanA-positive isolates, two vanB-positive isolates)...
We studied the source mechanism of mainshock (Ms˜ 7.5, Mo˜ 4.8 x 1019 N m) and largest aftershock 7.0, 4.7 1018 1967 Mogod earthquake sequence, 1974 July 4 event 6.9, 8.5 in Mongolia by synthesizing long-period teleseismic P- wave records WWSSN. These are only events with Ms greater than 5.5 which have occurred this area since installation In addition to modelling waveforms, we paid attention matching absolute amplitudes for all stations considered because both waveform amplitude contain...