A5082171498- Salivary Gland Disorders and Functions
- European Monetary and Fiscal Policies
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Economic theories and models
- Salivary Gland Tumors Diagnosis and Treatment
- Medication Adherence and Compliance
- Diabetes and associated disorders
- Health and Medical Studies
- Fiscal Policies and Political Economy
- Lymphoma Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Growth Hormone and Insulin-like Growth Factors
- Economic Policies and Impacts
- Periodontal Regeneration and Treatments
- Platelet Disorders and Treatments
- Galectins and Cancer Biology
- Financial Markets and Investment Strategies
- Global Financial Regulation and Crises
- Chemokine receptors and signaling
- Complex Systems and Decision Making
- Organ and Tissue Transplantation Research
Helmut Schmidt University
2012-2023
Universität Hamburg
2002-2023
ZBW – Leibniz-Informationszentrum Wirtschaft
2023
Behörde für Gesundheit und Verbraucherschutz
2023
Witten/Herdecke University
2018-2019
Johnson & Johnson (Germany)
2018-2019
Charité - Universitätsmedizin Berlin
2001-2011
Park-Klinik Weißensee
2010
Humboldt-Universität zu Berlin
2004
University Medical Center Hamburg-Eppendorf
2002
To develop a score for assessment of patients' symptoms in primary Sjögren's syndrome (SS): the EULAR SS Patient Reported Index (ESSPRI).Dryness, pain, somatic and mental fatigue were identified as main patients with SS, studies developing Profile Fatigue Discomfort (PROFAD) Sicca Symptoms Inventory (SSI). It was suspected that single 0-10 numerical scale each domain sufficient to assess these symptoms. These four scales gathered form ESSPRI. 230 patients, from 12 countries completed ESSPRI,...
For herpes simplex virus 1 (HSV-1) the skin is primary site of infection. After lytic infection, enters peripheral nervous system where it establishes latency. Spontaneous reactivation from latently infected neurons leads to typical HSV-1-induced diseases like cold sores. Modelling pathologies challenging due variety different cell types and structures in human-specific responses Nevertheless, studies using monolayer lines, raft cultures, ex vivo mouse models provided an immense contribution...
Health care systems worldwide are struggling to keep rising costs at bay with only modest outcome improvement among many diseases. Digitization technologies like Artificial Intelligence or Machine Learning algorithms might address this. Although digital have been successfully applied in clinical studies the effect on overall health system so far was limited. The regulatory ecosystem data privacy be responsible, but other reasons may also predominate.We analyzed how digitization of German...
Summary. Three patients with myelofibrosis received allogeneic stem cell transplantation after a dose‐reduced conditioning regimen of busulphan (8 mg/kg), fludarabine (180 mg/m 2 ) and antithymocyte globulin (4 × 10 mg/kg). The median age at was 51 years (range 44–58). All engrafted leucocyte count > 1·0 9 /l 18 d 16–20). Grade II acute skin graft‐versus‐host disease (GvHD) occurred in one patient. One limited extensive chronic GvHD observed. achieved complete haematological remission. In...
Recently, it has been stated that single-world interpretations of quantum theory are logically inconsistent. The claim is derived from contradicting statements agents in a setup combining two Wigner's-friend experiments. Those stem applying the measurement-update rule subjectively, i.e., only for respective agent's own measurement. We argue contradiction expresses incompatibility collapse and unitarity - resulting different formal descriptions measurement does not allow to dismiss any...
Abstract Myoepithelial sialadenitis (MESA) of the major salivary glands is a characteristic feature primary Sjögren's syndrome (pSS). To delineate systemic and organ‐specific influences on B cells in patient with pSS benign MESA, individual were simultaneously obtained from peripheral blood inflamed parotid gland. Immunoglobulin variable heavy chain (V H ) rearrangements single sorted CD19 + subsequently amplified, sequenced analysed. Despite presence two clonal expansions using V 1‐08 2‐70...
Nonadherence to medication is a driver of morbidity and mortality, complex regimens in patients with chronic diseases foster the problem. Digital technology might help, but despite numerous solutions being developed, none are currently widely used, acceptance rates remain low, especially among elderly.
Patients with Sjögren's syndrome (SS) have characteristic lymphocytic infiltration of the salivary glands a previously reported predominance Vkappa-bearing B cells and produce variety autoantibodies, indicating that there is humoral autoimmune component in this syndrome. This study was undertaken to determine whether are primary deviations immunoglobulin V gene usage, differences somatic hypermutation, defects selection, or indications for perturbances cell maturation SS.Individual...
Abstract The rising debt-to-GDP ratios of the eurozone member states result not least from coronavirus crisis. Without external support, especially with regard to Italy, but also for other Mediterranean states, access capital market could be seriously threatened in medium run. recovery fund ‘Next Generation EU’ likely directs fundamental structures European Union (EU) towards a fiscal union considerable transfer elements, while Pandemic Emergency Purchase Programme (PEPP), which is declared...
Abstract The coronavirus crisis has led to a sharp increase in the debt-to-GDP ratios of euro area member states. Without external support, access capital market could be seriously threatened medium term for Italy, but also other While Pandemic Emergency Purchase Programme, which is designed as monetary policy instrument, regarded by some violation prohibition financing, Next Generation EU recovery fund likely direct fundamental structures European Union towards fiscal union with...