A5030053511- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- COVID-19 Impact on Reproduction
- Assisted Reproductive Technology and Twin Pregnancy
- Immune Cell Function and Interaction
- Reproductive Biology and Fertility
- Influenza Virus Research Studies
- Immune responses and vaccinations
- SARS-CoV-2 and COVID-19 Research
- Endometriosis Research and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Electrolyte and hormonal disorders
- Anesthesia and Neurotoxicity Research
- Epigenetics and DNA Methylation
- Eicosanoids and Hypertension Pharmacology
- Stress Responses and Cortisol
- COVID-19 and healthcare impacts
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Cancer Risks and Factors
Universität Hamburg
2015-2024
University Medical Center Hamburg-Eppendorf
2015-2024
Sartorius (Germany)
2024
University of Rostock
2023
Reproductive Science Center
2023
Harvard University
2023
Massachusetts General Hospital
2023
Bayer (Germany)
2019
During mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric (MMc) in the offspring is mostly unknown. Here we show a mouse model which MMc numbers either normal or low, enables assessment MMc. We report promoting fetal development. induces preferential differentiation hematopoietic stem bone marrow towards monocytes within myeloid compartment. Neonatal mice with higher and enhanced resilience against...
Abstract Innovations in viral vaccine manufacturing are crucial for pandemic preparedness and to meet ever‐rising global demands. For influenza, however, production still mainly relies on technologies established decades ago. Although modern shifts from egg‐based towards cell culture technologies, the full potential has not yet been fully exploited. Here, we evaluate whether implementation of state‐of‐the‐art culture‐based recombinant protein capable challenge outdated approaches process...
Abstract Life-long brain function and mental health are critically determined by developmental processes occurring before birth. During mammalian pregnancy, maternal cells transferred to the fetus. They referred as microchimeric (MMc). Among other organs, MMc seed into fetal brain, where their is unknown. Here, we show that, in offspring’s developing mice, express a unique signature of sensome markers, control microglia homeostasis prevent excessive presynaptic elimination. Further,...
Up to 10% of pregnancies in Western societies are affected by intrauterine growth restriction (IUGR). IUGR reduces short-term neonatal survival and impairs long-term health the children. To date, molecular mechanisms involved pathogenesis largely unknown, but failure mount an adequate endocrine immune response during pregnancy has been proposed facilitate occurrence IUGR. A cross talk between hormone progesterone innate cell subsets such as dendritic cells (DCs) is vital ensure placentation...
The RUPP procedure is a well-established model for studying the link between placental ischemia and hypertension in pregnant rat has been described detail previously.( 1) First timed Sprague-Dawley rats purchased from Harlan Sprague Dawley Inc. (Indianapolis, IN) were used this study.Twenty-eight randomly assigned to either NP, NP rAgt-targeting siRNA, or siRNA group.On day 12 of gestation (GD), was subcutaneously injected into (10 mg/kg).On gestational 14, under isoflurane
Pregnant women have been carefully observed during the COVID-19 pandemic, as pregnancy-specific immune adaptation is known to increase risk for infections. Recent evidence indicates that even though most pregnant a mild or asymptomatic course, severe course of and higher progression diseases also described, along with heightened pregnancy complications. Yet, vertical transmission virus rare possibility placental SARS-CoV-2 infection prerequisite requires further studies. We here assessed...
BackgroundPrenatal challenges such as maternal stress perception increase the risk and severity of asthma during childhood. However, insights into trajectories targets underlying pathogenesis prenatally triggered are largely unknown. The developing lung immune system may constitute targets.ObjectiveHere we have aimed to identify differential sex-specific effects prenatal on function, response, in mice.MethodsWe generated bone marrow chimeric (BMC) mice harboring either stress-exposed lungs...
<b>Background:</b> Prenatal adversities can increase the risk and severity of lung diseases. Sex differences play a role in pathogenesis such Little is known about impact prenatal on sex-differences health. <b>Aims:</b> Here, we aimed to examine if how stress affects sexual dimorphism respiratory infections with strong female bias (Influenza A, IAV) through modulation lung-resident immunity. <b>Methods:</b> Pregnant C57BL/6 mice were exposed sound gestational days 9.5, 11.5, 13.5, 15.5. 8...
Vectored vaccines based on highly attenuated modified vaccinia Ankara (MVA) are reported to be immunogenic, tolerant pre-existing immunity, and able accommodate stably maintain very large transgenes. MVA is usually produced primary chicken embryo fibroblasts, but production processes continuous cell lines emerge as increasingly robust cost-effective alternatives. An isolate of a hitherto undescribed genotype was recovered by passage non-plaque-purified preparation in anatine suspension line...
Maternal microchimerism, which occurs naturally during gestation in hemochorial placental mammals upon transplacental migration of maternal cells into the fetus, is suggested to significantly influence fetal immune system. In our previous publication, we explored sensitivity quantitative polymerase chain reaction and flow cytometry detect cellular microchimerism. With that purpose, created mixed suspensions vitro containing reciprocal frequencies wild type positive for enhanced green...
A wealth of innate and adaptive immune cells hormones are involved in mounting tolerance towards the fetus, a key aspect successful reproduction. We could recently show that specific cross talk between pregnancy hormone progesterone dendritic (DCs) is significantly engaged generation CD4+ FoxP3+ regulatory T (Treg) while disruption led to placental alterations intra-uterine growth restriction. Apart from progesterone, also glucocorticoids affect cell functions. However, their functional...