A5071604538- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Olfactory and Sensory Function Studies
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Stress Responses and Cortisol
- Multisensory perception and integration
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Neurobiology and Insect Physiology Research
- Reproductive Biology and Fertility
- EEG and Brain-Computer Interfaces
- Phosphodiesterase function and regulation
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Neonatal and fetal brain pathology
- Epilepsy research and treatment
- Birth, Development, and Health
Universität Hamburg
2016-2025
University Medical Center Hamburg-Eppendorf
2016-2025
Institute of Developmental Physiology
2019
University of Basel
2017
FENS Kavli Network of Excellence
2015-2016
University Medical Center of the Johannes Gutenberg University Mainz
2014
Johannes Gutenberg University Mainz
2009-2014
University Medical Center
2012
Coordinated patterns of electrical activity are important for the early development sensory systems. The spatiotemporal dynamics these and role peripheral input their generation essentially unknown. We performed extracellular multielectrode recordings in somatosensory cortex postnatal day 0 to 7 rats vivo observed three distinct synchronized oscillatory activity. (1) Spontaneous periphery-driven spindle bursts 1–2 s duration ∼10 Hz frequency occurred approximately every 10 s. (2)...
Throughout development, the brain transits from early highly synchronous activity patterns to a mature state with sparse and decorrelated neural activity, yet mechanisms underlying this process are poorly understood. The developmental transition has important functional consequences, as latter is thought allow for more efficient storage, retrieval, processing of information. Here, we show that, in mouse medial prefrontal cortex (mPFC), during first two postnatal weeks decorrelates following...
The transmission of the heartbeat through cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, elicited correlated local field oscillations in olfactory bulb mitral cell layer. These did not require synaptic but reflected baroreceptive transduction cells. This was mediated by fast excitatory mechanosensitive ion channel and modulated spiking awake...
Abstract Atypical brain connectivity is a major contributor to the pathophysiology of neurodevelopmental disorders (NDDs) including autism spectrum (ASDs). TAOK2 one several genes in 16p11.2 microdeletion region, but whether it contributes NDDs unknown. We performed behavioral analysis on Taok2 heterozygous (Het) and knockout (KO) mice found gene dosage-dependent impairments cognition, anxiety, social interaction. Het KO also have abnormalities size neural multiple regions, deficits cortical...
Background: Schizophrenia has long been suggested to represent a disorder with prominent neural dysconnectivity. Gamma-band oscillations are highly relevant in this context, due both their proposed involvement neuronal synchronization and association neurotransmitter systems for schizophrenia. Several task-related studies have confirmed reduced power of gamma-band schizophrenia, but it that these findings might not apply the resting state. The present study aimed investigate resting-state...
Abstract Coordinated activity patterns in the developing brain may contribute to wiring of neuronal circuits underlying future behavioural requirements. However, causal evidence for this hypothesis has been difficult obtain owing absence tools selective manipulation oscillations during early development. We established a protocol that combines optogenetics with electrophysiological recordings from neonatal mice vivo elucidate substrate network prefrontal cortex. show light-induced activation...
Disturbed neuronal activity in neuropsychiatric pathologies emerges during development and might cause multifold dysfunction by interfering with apoptosis, dendritic growth, synapse formation. However, how altered electrical early life affects function behavior adults is unknown. Here, we address this question transiently increasing the coordinated of layer 2/3 pyramidal neurons medial prefrontal cortex neonatal mice monitoring long-term functional behavioral consequences. We show that...
Optimal behavior relies on the successful integration of complementary information from multiple senses. The neural mechanisms underlying multisensory interactions are still poorly understood. Here, we demonstrate critical role network oscillations and direct connectivity between primary sensory cortices in visual-somatosensory interactions. Extracellular recordings all layers barrel field Brown Norway rats vivo showed that bimodal stimulation (simultaneous light flash whisker deflection)...
The fate of the subplate (SP) is still a matter debate. SP and layer 6 (which ontogenetically oldest innermost neocortical lamina) develop coincidentally. Yet, function sublamina 6B largely unknown. It has been suggested that it consists partly neurons from transient SP, however, experimental evidence for this hypothesis missing. To obtain first insights into neuronal complement in somatosensory rat barrel cortex, we used biocytin stainings (aged 0–4 postnatal days, PND) (PND 11–35) obtained...
Abstract Early life exposure to stressful situations impairs cognitive performance of adults and contributes the etiology several psychiatric disorders. Most affected abilities rely on coupling by synchrony within complex neuronal networks, including prefrontal cortex (PFC), hippocampus (HP), perirhinal (PRH). Yet it remains poorly understood how early stress (ELS) induces dysfunction these networks during course development. Here we used intermittent maternal separation first 2 postnatal...
Cognitive deficits, core features of mental illness, largely result from dysfunction prefrontal networks. This emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling abnormal maturation are still unknown. Here, we address this open question by combining in vivo electrophysiology, optogenetics, neuroanatomy, and assays development mice mimicking dual genetic-environmental etiology psychiatric disorders. We report that pyramidal neurons...
Gamma oscillations are a prominent activity pattern in the cerebral cortex. While gamma rhythms have been extensively studied adult prefrontal cortex context of cognitive (dys)functions, little is known about their development. We addressed this issue by using extracellular recordings and optogenetic stimulations mice across postnatal show that fast rhythmic becomes during second week. initially at 15 Hz, oscillatory progressively accelerates with age stabilizes within frequency range (30-80...
General anesthesia is characterized by reversible loss of consciousness accompanied transient amnesia. Yet, long-term memory impairment an undesirable side effect. How different types general anesthetics (GAs) affect the hippocampus, a brain region central to formation and consolidation, poorly understood. Using extracellular recordings, chronic 2-photon imaging, behavioral analysis, we monitor effects isoflurane (Iso), medetomidine/midazolam/fentanyl (MMF), ketamine/xylazine (Keta/Xyl) on...
Most cognitive functions involving the prefrontal cortex emerge during late development. Increasing evidence links this delayed maturation to protracted timeline of development, which likely does not reach full maturity before end adolescence. However, underlying mechanisms that drive emergence and fine-tuning abilities adolescence, caused by circuit wiring, are still unknown. Here, we continuously monitored activity throughout postnatal development mice showed an initial increase was...
The interplay between olfaction and higher cognitive processing has been documented in the adult brain; however, its development is poorly understood. In mice, shortly after birth, endogenous stimulus-evoked activity olfactory bulb (OB) boosts oscillatory entrainment of downstream lateral entorhinal cortex (LEC) hippocampus (HP). However, it unclear whether early OB a long-lasting impact on entorhinal-hippocampal function processing. Here, we chemogenetically silenced synaptic outputs...
Abstract Sharp wave-ripples (SPW-Rs) are a hippocampal network phenomenon critical for memory consolidation and planning. SPW-Rs have been extensively studied in the adult brain, yet their developmental trajectory is poorly understood. While SPWs recorded rodents shortly after birth, time point mechanisms of ripple emergence still unclear. Here, we combine vivo electrophysiology with optogenetics chemogenetics 4 to 12-day-old mice address this knowledge gap. We show that ripples robustly...
The hippocampus-driven entrainment of neonatal prefrontal circuits in theta-gamma oscillations contributes to the maturation cognitive abilities, yet underlying synaptic mechanisms are still unknown.Here we combine patch-clamp recordings from morphologically and neurochemically characterized layer V pyramidal neurons interneurons vivo, with extracellular prelimbic cortex (PL) awake lightly anesthetized rats, elucidate framework early network oscillations.We demonstrate that all spontaneously...