A5055780644- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- stochastic dynamics and bifurcation
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Neural Networks and Applications
- Neuroscience and Music Perception
- Diet and metabolism studies
- Neuroscience and Neural Engineering
- Amyotrophic Lateral Sclerosis Research
- RNA and protein synthesis mechanisms
- Ion Transport and Channel Regulation
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Neurogenesis and neuroplasticity mechanisms
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
University of Cologne
2017-2021
German Center for Neurodegenerative Diseases
2015-2021
University Medical Center Hamburg-Eppendorf
2011-2017
Universität Hamburg
2011-2017
Rutgers, The State University of New Jersey
2006-2012
Even in the absence of sensory stimulation, neocortex shows complex spontaneous activity patterns, often consisting alternating "DOWN" states generalized neural silence and "UP" massive, persistent network activity. To investigate how this propagates through neuronal assemblies vivo, we simultaneously recorded populations 50-200 cortical neurons layer V anesthetized awake rats. Each neuron displayed a virtually unique spike pattern during UP states, with diversity seen amongst both putative...
The responses of neocortical cells to sensory stimuli are variable and state dependent. It has been hypothesized that intrinsic cortical dynamics play an important role in trial-to-trial variability; the precise nature this dependence, however, is poorly understood. We show here auditory cortex urethane-anesthetized rats, population click can be quantitatively predicted on a trial-by-trial basis by simple dynamical system model estimated from spontaneous activity immediately preceding...
Cortical responses can vary greatly between repeated presentations of an identical stimulus. Here we report that both trial-to-trial variability and faithfulness auditory cortical stimulus representations depend critically on brain state. A frozen amplitude-modulated white noise was repeatedly presented while recording neuronal populations local field potentials (LFPs) in cortex urethane-anesthetized rats. An information-theoretic measure used to predict spiking activity from either the...
Cortical circuits encode sensory stimuli through the firing of neuronal ensembles, and also produce spontaneous population patterns in absence drive. This activity is often characterized experimentally by distribution multineuron "words" (binary vectors), a match between evoked word distributions has been suggested to reflect learning probabilistic model world. We analyzed cortex anesthetized rats cats, found that they are dominated fluctuations rate rather than precise interactions...
Abstract Neural representations of even temporally unstructured stimuli can show complex temporal dynamics. In many systems, neuronal population codes ‘progressive differentiation’, whereby responses to different grow further apart during a stimulus presentation. Here we analysed the response auditory cortical populations in rats extended tones. At onset (up 300 ms), tone involved strong excitation large number neurons; sustained (after 500 ms) overall firing rate decreased, but most cells...
Significance Neuronal circuits develop in an activity-dependent manner. In vitro data suggest that the intracellular accumulation of chloride—a universal characteristic immature nerve cells—drives network maturation through a depolarizing action neurotransmitter GABA. We here demonstrate deletion chloride cotransporter NKCC1 from forebrain pyramidal cells severely impairs hippocampal synchrony vitro. contrast, has weak and event type-dependent effects on spontaneous activity vivo, loss...
The hippocampus plays an essential role in learning. Each of the three major hippocampal subfields, dentate gyrus (DG), CA3, and CA1, has a unique function memory formation consolidation, also exhibit distinct local field potential (LFP) signatures during consolidation processes non-rapid eye movement (NREM) sleep. classic LFP events CA1 region, sharp-wave ripples (SWRs), are induced by CA3 activity considered to be electrophysiological biomarker for episodic memory. In recordings along...
Abstract NKCC1 is the primary transporter mediating chloride uptake in immature principal neurons, but its role development of vivo network dynamics and cognitive abilities remains unknown. Here, we address function developing mice using electrophysiological, optical behavioral approaches. We report that deletion from telencephalic glutamatergic neurons decreases in-vitro excitatory GABA actions impairs neuronal synchrony neonatal hippocampal brain slices. In , it has a minor impact on...