A5038141417- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Ion channel regulation and function
- Sleep and Wakefulness Research
- stochastic dynamics and bifurcation
- Conducting polymers and applications
- Circadian rhythm and melatonin
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Tryptophan and brain disorders
- Advanced Memory and Neural Computing
- scientometrics and bibliometrics research
- Academic Writing and Publishing
- Stress Responses and Cortisol
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- Neuroendocrine regulation and behavior
- Nonlinear Dynamics and Pattern Formation
- Biomedical Text Mining and Ontologies
Inserm
2016-2025
Aix-Marseille Université
2016-2025
Institut de Neurosciences des Systèmes
2016-2025
Université Clermont Auvergne
2024
Observatoire de Physique du Globe de Clermont-Ferrand
2024
Centre National de la Recherche Scientifique
2024
University of Kansas
2024
École Supérieure de Commerce de Toulouse
2023
Institut National de Recherche en Santé Publique
2007-2021
Health Affairs
2017-2018
In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic purposes and brain-machine interfaces. Organic electronic devices constitute a promising candidate because their mechanical flexibility biocompatibility. Here we demonstrate the engineering an organic electrochemical transistor embedded in ultrathin film designed to record signals on surface brain. The device, tested epileptiform discharges, displayed superior signal-to-noise ratio due local...
Seizures can occur spontaneously and in a recurrent manner, which defines epilepsy; or they be induced normal brain under variety of conditions most neuronal networks species from flies to humans. Such universality raises the possibility that invariant properties exist characterize seizures different physiological pathological conditions. Here, we analysed seizure dynamics mathematically established taxonomy based on first principles. For predominant class developed generic model called...
Despite recent interest in organic electrochemical transistors (OECTs), sparked by their straightforward fabrication and high performance, the fundamental mechanism behind operation remains largely unexplored. OECTs use an electrolyte direct contact with a polymer channel as part of device structure. Hence, they offer facile integration biological milieux are currently used amplifying transducers for bioelectronics. Ion exchange between is believed to take place OECTs, although extent this...
Inherited channelopathies are at the origin of many neurological disorders. Here we report a form channelopathy that is acquired in experimental temporal lobe epilepsy (TLE), most common adults. The excitability CA1 pyramidal neuron dendrites was increased TLE because decreased availability A-type potassium ion channels due to transcriptional (loss channels) and posttranslational (increased channel phosphorylation by extracellular signal-regulated kinase) mechanisms. Kinase inhibition partly...
A photolithographic process was used to integrate the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) with parylene C, yielding highly conformable electrode arrays that were only four micrometers thick (shown here conform midrib of a small leaf). The sufficiently self-supporting allow in vivo evaluation rats, high-quality electrocorticography recordings.
Various methods have been proposed to characterize the functional connectivity between nodes in a network measured with different modalities (electrophysiology, magnetic resonance imaging etc.). Since measures of yield results for same dataset, it is important assess when and how they can be used. In this work, we provide systematic framework evaluating performance large range – based upon comprehensive portfolio models generating measurable responses. Specifically, benchmarked 42 using...
Stressful life events produce a state of vulnerability to depression in some individuals. The mechanisms that contribute remain poorly understood. A rat model intense stress (social defeat (SD), first hit) produced 40% animals. Only vulnerable animals developed depression-like phenotype after second stressful hit (chronic mild stress). We found this resulted from persistent oxidative stress, which was reversed by treatment with antioxidants. This due low brain-derived neurotrophic factor...
Temporal lobe epilepsy (TLE) in humans and animals is associated with axonal sprouting of glutamatergic neurons neosynaptogenesis the hippocampal formation. We examined whether this plasticity excitatory pathways contributes to an increased level excitation CA1 region rats experiencing chronic spontaneous limbic seizures following kainic acid or pilocarpine treatment. In cases, we report extensive pyramidal neurons, many branches entering cell layer stratum radiatum, regions that are not...
Patients with temporal lobe epilepsy (TLE), the most common form of in adults, often display cognitive deficits. The time course and underlying mechanisms decline remain unknown during epileptogenesis (the process leading to epilepsy). Using rat pilocarpine model TLE, we performed a longitudinal study assess spatial nonspatial performance epileptogenesis. In parallel, monitored interictal-like activity (ILA) hippocampal CA1 region, as well theta oscillations, brain rhythm central numerous...
Loss of consciousness (LOC) is a dramatic clinical manifestation temporal lobe seizures. Its underlying mechanism could involve altered coordinated neuronal activity between the brain regions that support conscious information processing. The access hypothesis assumes existence global workspace in which becomes available via synchronized within modules, often widely distributed throughout brain. Re-entry loops and, particular, thalamo-cortical communication would be crucial to functionally...
Morphological studies suggest that the primate hippocampus develops extensively before birth, but little is known about its functional development. Patch-clamp recordings of hippocampal neurons and reconstruction biocytin-filled pyramidal cells were performed in slices macaque cynomolgus fetuses delivered by cesarean section. We found during second half gestation, axons dendrites grow intensively hundreds micrometers per day to attain a high level maturity near term. Synaptic currents appear...
A depolarized resting membrane potential has long been considered to be a universal feature of immature neurons. Despite the physiological importance, underlying mechanisms this developmental phenomenon are poorly understood. Using perforated-patch, whole cell, and cell-attached recordings, we measured in CA3 pyramidal cells hippocampal slices from postnatal rats. With gramicidin perforated-patch was -44 +/- 4 (SE) mV at days P0-P2, it progressively shifted -67 2 P13-15. similar change also...
A stressful event increases the risk of developing depression later in life, but possible predisposing factors remain unknown. Our study aims to characterize latent vulnerability traits underlying development depressive disorders adult animals. Four weeks after a priming event, serum corticosterone concentration returned control values all animals, whereas other biological parameters basal level only 58% animals (called nonvulnerable). In contrast, 42% displayed persistent decreased and...
Enduring, abnormal expression and function of the ion channel hyperpolarization-activated cyclic adenosine monophosphate gated type 1 (HCN1) occurs in temporal lobe epilepsy (TLE). We examined underlying mechanisms, investigated whether interfering with these mechanisms could modify disease course.Experimental TLE was provoked by kainic acid-induced status epilepticus (SE). HCN1 repression at mRNA, protein, functional levels. Chromatin immunoprecipitation employed to identify transcriptional...
Consumption of certain substances during pregnancy can interfere with brain development, leading to deleterious long-term neurological and cognitive impairments in offspring. To test whether modulators adenosine receptors affect neural we exposed mouse dams a subtype-selective type 2A receptor (A2AR) antagonist or caffeine, naturally occurring antagonist, lactation. We observed delayed migration insertion γ-aminobutyric acid (GABA) neurons into the hippocampal circuitry first postnatal week...