A5026921199- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Microbial Metabolic Engineering and Bioproduction
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Sleep and Wakefulness Research
- Silk-based biomaterials and applications
- Enzyme Catalysis and Immobilization
- Photoreceptor and optogenetics research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer-related Molecular Pathways
- Ion Transport and Channel Regulation
- Glioma Diagnosis and Treatment
- DNA Repair Mechanisms
German Center for Neurodegenerative Diseases
2015-2022
University of Cologne
2020-2022
Brandenburg University of Technology Cottbus-Senftenberg
2014
The hippocampus plays an essential role in learning. Each of the three major hippocampal subfields, dentate gyrus (DG), CA3, and CA1, has a unique function memory formation consolidation, also exhibit distinct local field potential (LFP) signatures during consolidation processes non-rapid eye movement (NREM) sleep. classic LFP events CA1 region, sharp-wave ripples (SWRs), are induced by CA3 activity considered to be electrophysiological biomarker for episodic memory. In recordings along...
De novo mutations in voltage- and ligand-gated channels have been associated with an increasing number of cases developmental epileptic encephalopathies, which often fail to respond classic antiseizure medications. Here, we examine two knock-in mouse models replicating de sequence variations the human HCN1 voltage-gated channel gene, p.G391D p.M153I (Hcn1G380D/+ Hcn1M142I/+ mouse), severe drug-resistant neonatal- childhood-onset epilepsy, respectively. Heterozygous mice from both lines...
Abstract De novo mutations in voltage- and ligand-gated channels have been associated with an increasing number of cases developmental epileptic encephalopathies, which often fail to respond classic antiseizure medications. Here, we examine two knock-in mouse models replicating de the HCN1 voltage-gated channel gene, p.G391D p.M153I ( Hcn1 G380D/+ M142I/+ mouse), severe drug-resistant neonatal- childhood-onset epilepsy, respectively. Heterozygous mice from both lines displayed spontaneous...