A5033727122- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- Cardiovascular Issues in Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Function and Risk Factors
- Hops Chemistry and Applications
- Cardiovascular Disease and Adiposity
- Garlic and Onion Studies
- MicroRNA in disease regulation
- Diet and metabolism studies
- Microscopic Colitis
- Inflammatory Bowel Disease
- Mitochondrial Function and Pathology
- Cardiac Imaging and Diagnostics
- Reproductive System and Pregnancy
- Phytoestrogen effects and research
- Adipose Tissue and Metabolism
- Renal and related cancers
- Traumatic Brain Injury and Neurovascular Disturbances
- Metabolism and Genetic Disorders
- Menopause: Health Impacts and Treatments
- Acute Myocardial Infarction Research
- Cardiac Ischemia and Reperfusion
Max Delbrück Center
2017-2025
German Centre for Cardiovascular Research
2017-2024
Charité - Universitätsmedizin Berlin
2018-2024
Humboldt-Universität zu Berlin
2018-2024
Freie Universität Berlin
2018-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2017-2021
TU Dresden
2014-2015
Max Planck Institute of Molecular Cell Biology and Genetics
2014
Arterial hypertension and its organ sequelae show characteristics of T cell-mediated inflammatory diseases. Experimental anti-inflammatory therapies have been shown to ameliorate hypertensive end-organ damage. Recently, the CANTOS study (Canakinumab Antiinflammatory Thrombosis Outcome Study) targeting interleukin-1β demonstrated that therapy reduces cardiovascular risk. The gut microbiome plays a pivotal role in immune homeostasis health. Short-chain fatty acids (SCFAs) are produced from...
Abstract Background Ulcerative colitis (UC) is a chronic relapsing-remitting disease characterized by distinct molecular patterns and proinflammatory pathways. Through advances in therapy monitoring-strategies, long lasting remission can be achieved an increasing number of patients. Our aim to investigate cytokine signatures the interstitial microenvironment at protein RNA level UC patients showing deep (DR) better understand response existing therapies. We hypothesize that DR forms group...
Abstract Background Proinflammatory cytokines identified in the mucosal microenvironment at site of inflammation are involved pathophysiology chronic inflammatory bowel diseases such as ulcerative colitis (UC). We hypothesize that local cytokine production is significantly altered inflamed regions intestine and cannot be predicted by plasma measurements. Our goal to identify personalized signatures UC patients' interstitial space depending on their disease progression. This can advance our...
Heart failure with preserved ejection fraction (HFpEF) can arise from cardiac and vascular remodeling processes following long-lasting hypertension. Efficacy of common HF therapeutics is unsatisfactory in HFpEF. Evidence suggests that stimulators the nitric oxide–sensitive soluble guanylyl cyclase (NOsGC) could be use here. We aimed to characterize complex cardiovascular effects NOsGC stimulation using NO-independent stimulator BAY 41-8543 a double-transgenic rat (dTGR) model show...
Preeclampsia is associated with increased cardiovascular long-term risk; however, the underlying functional and structural mechanisms are unknown. We investigated maternal cardiac alterations after preeclampsia. Female rats harboring human angiotensinogen gene [TGR(hAogen)L1623] develop a preeclamptic phenotype hypertension albuminuria during pregnancy when mated male bearing renin [TGR(hRen)L10J] but behave physiologically normal before pregnancy. Furthermore, were treated pravastatin....
The RUPP procedure is a well-established model for studying the link between placental ischemia and hypertension in pregnant rat has been described detail previously.( 1) First timed Sprague-Dawley rats purchased from Harlan Sprague Dawley Inc. (Indianapolis, IN) were used this study.Twenty-eight randomly assigned to either NP, NP rAgt-targeting siRNA, or siRNA group.On day 12 of gestation (GD), was subcutaneously injected into (10 mg/kg).On gestational 14, under isoflurane
The mineralocorticoid aldosterone increases in plasma healthy pregnancy along with renin and angiotensin II plays a key role the physiological volume expansion. In mice, contributes to an optimal fetal development by enhancing PlGF (placental growth factor) expression trophoblast cell proliferation. preeclampsia, there is coincident suppression of impaired placental development. We hypothesized that independently birth weight humans, high dietary sodium low potassium intakes affect this...
Pregnancy-induced hypertension is a severe pregnancy complication, increasing risk of long-term cardiovascular disease in mothers and offspring. We hypothesized that maternal blood pressure associated with offspring pressure; the associations were sex-specific; circulating placental angiogenic markers (PlGF [placental growth factor] sFlt-1 [soluble fms-like tyrosine kinase-1]) mediated this relationship. analyzed data from 2434 women 2217 children Odense Child Cohort, prospective Danish...
One driving factor for developing preeclampsia—a pregnancy disorder, often associated with poor spiral artery (SpA)-remodeling and fetal growth restriction—is the anti-angiogenic sFLT1 (soluble fms-like tyrosine kinase-1), which is found to be highly upregulated in preeclampsia patients. The sFLT1-mediated endothelial dysfunction a common theory manifestation of maternal symptoms. However, influence on SpA-remodeling link between placental symptoms less understood. To dissect hsFLT1 (human...
Diabetic pregnancy is correlated with increased risk of metabolic and neurological disorders in the offspring putatively mediated epigenetically. Little known about epigenetic changes already present fetuses diabetic pregnancies. We aimed at characterizing perinatal environment after preexisting maternal diabetes mellitus identifying relevant fetus. focused on transcription factor Srebf2 (sterol regulatory element binding 2), a master gene regulation cholesterol metabolism. tested whether...
Reduced expression of the plasma membrane citrate transporter INDY (acronym I'm Not Dead, Yet) extends life span in lower organisms. Deletion mammalian Indy (mIndy) gene rodents improves metabolism via mechanisms akin to caloric restriction, known blood pressure (BP) by sympathoadrenal inhibition. We hypothesized that mIndy deletion attenuates support BP. Continuous arterial BP and heart rate (HR) were reduced mINDY-KO mice. Concomitantly, urinary catecholamine content was lower, decreases...
BACKGROUND: Preeclampsia is a severe hypertensive disorder in pregnancy that causes preterm delivery, maternal and fetal morbidity, mortality, life-long sequelae. Understanding the pathogenesis of preeclampsia critical first step toward protecting mother child from this syndrome increased risk cardiovascular disease later life. However, effective early predictive tests therapies for are scarce. METHODS: To identify novel markers signaling pathways onset preeclampsia, we profiled human...
Echocardiography is the most commonly applied technique for non-invasive assessment of cardiac function in small animals. Manual tracing endocardial borders time consuming and varies with operator experience. Therefore, we aimed to evaluate a novel automated two-dimensional software algorithm (Auto2DE) animals compare it standard use manual 2D-echocardiographic (2DE). We hypothesized that Auto2DE will provide rapid robust data sets, which are agreement manually assessed animals.2DE were...
Several studies have shown that women with a preeclamptic pregnancy exhibit an increased risk of cardiovascular disease. However, the underlying molecular mechanisms are unknown. Animal models essential to investigate causes this and ability assess possible preventive therapeutic interventions. Using latest technologies such as speckle tracking echocardiography (STE), it is feasible map subclinical changes in cardiac diastolic systolic function well structural maternal heart. The aim work...
The placenta is a temporary organ with unique structure and function to ensure healthy fetal development. Placental dysfunction involved in pre-eclampsia (PE), growth restriction, preterm birth, gestational diabetes mellitus (GDM). A diabetic state affects maternal health may lead functional alterations of placental metabolism, inflammation, hypoxia, weight, amplifying the stress. molecular adaptations environment adaptive spatio-temporal consequences elevated glucose or insulin are largely...
Type 2 diabetes mellitus and hypertension are two major risk factors leading to heart failure cardiovascular damage. Lowering blood sugar by the sodium-glucose co-transporter inhibitor empagliflozin provides cardiac protection. We established a new rat model that develops both inducible genetic investigated effect of treatment test hypothesis if will be protective in which is not based on primary vascular event. The transgenic Tet29 for was crossed with mRen27 hypertensive create novel...
Bone protection and metabolism are directly linked to estrogen levels, but exercise is also considered have bone protective effects. Reduced levels lead a variety of disorders, for example, loss reduced movement drive. The objective this study was investigate the effects on individual voluntary motivation protection. We investigated sham operated, ovariectomized, ovariectomized with supplemented Wistar rats (20 weeks old) either or without access wheels. selected an experimental approach...
Preeclampsia (PE) is characterized by the onset of hypertension (≥140/90 mmHg) and presence proteinuria (>300 mg/L/24 h urine) or other maternal organ dysfunctions. During human PE, renal injuries have been observed. Some studies suggest that women with PE diagnosis an increased risk to develop diseases later in life. However, as a single cause this development cannot be investigated. Here, we aimed investigate effect on postpartum damage established transgenic rat model. Female rats...
Objective: Hypertension before and during early pregnancy has been associated with an increased risk of gestational diabetes mellitus (GDM) in retrospective analyses. We aimed to investigate the prospective blood pressure trackings a population-based cohort pregnant women, who were stratified according their metabolic status third trimester. Methods: recorded longitudinally 1230 women from Odense Child Cohort, Denmark. Fasting glucose insulin measured at weeks 28–30. Metabolic was evaluated...
Summary Pre-eclampsia (PE) is a syndrome that affects multiple organ systems and the most severe hypertensive disorder in pregnancy. It frequently leads to preterm delivery, maternal fetal morbidity mortality life-long complications 1 . We currently lack efficient screening tools 2, 3 early therapies 4, 5 address PE. To investigate stages of onset PE, identify candidate markers pathways, we performed spatio-temporal multi-omics profiling human PE placentae healthy controls validated targets...
Diabetes in pregnancy is a major burden with acute and long-term consequences. Its treatment requires adequate diagnosis monitoring of therapy. Many experimental research on diabetes during has been performed rats. Recently, continuous blood glucose non-pregnant diabetic rats revealed an increased circadian variability that made single measurement per day inappropriate to reflect glycemic status. Continuous never pregnant We wanted perform decipher the influence normoglycemic used transgenic...
Objective: Preeclampsia is associated with an elevated risk of cardiovascular disease later in life. Women a history preeclampsia are at developing hypertension as well ischemic heart disease. Identification women the highest important to initiate preventive strategies. We investigated whether high-sensitivity cardiac troponin I (hs-cTnI) levels early-onset preeclampsia, and these high-risk women. Methods: Approximately 9–10 years after pregnancy, hs-cTnI were measured for 339 Risk...