A5015057743- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Cancer Genomics and Diagnostics
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Congenital Diaphragmatic Hernia Studies
- Prostate Cancer Treatment and Research
- COVID-19 Impact on Reproduction
- Genetic Syndromes and Imprinting
- Cancer Cells and Metastasis
- Assisted Reproductive Technology and Twin Pregnancy
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Clinical Laboratory Practices and Quality Control
- Genetic factors in colorectal cancer
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Statistical Methods in Clinical Trials
- MicroRNA in disease regulation
- Cell Image Analysis Techniques
- Gene expression and cancer classification
- RNA Research and Splicing
- AI in cancer detection
- Congenital Anomalies and Fetal Surgery
- COVID-19 and healthcare impacts
Medical University of Graz
2020-2025
Center For Biomarker Research In Medicine
2020-2024
University of Graz
2021
BACKGROUND: Preeclampsia is a severe hypertensive disorder in pregnancy that causes preterm delivery, maternal and fetal morbidity, mortality, life-long sequelae. Understanding the pathogenesis of preeclampsia critical first step toward protecting mother child from this syndrome increased risk cardiovascular disease later life. However, effective early predictive tests therapies for are scarce. METHODS: To identify novel markers signaling pathways onset preeclampsia, we profiled human...
Liquid biopsies are emerging as valuable clinical biomarkers for cancer monitoring. Although International Organization Standards (ISO) and Technical Specifications from the European Committee Standardization (CEN/TS) standardized workflows exist, their implementation in practice is underdeveloped. We aimed to assess applicability of ISO CEN/TS standards a real-world setting, with particular focus on evaluating impact preanalytical parameters hemolysis liquid biopsy analysis.
The Microchimerism Literature Atlas (MCLA) is a comprehensive online dataset to facilitate the investigation of microchimerism (MC), condition where individuals harbor cells from another individual same species. MCLA provides access more than 15 000 references MC research, covering peer-reviewed articles and reviews 1970 present. Key features include multidimensional search function logical operators for assembling queries. offers clearly structured data table view, combined with dynamic...
Novel androgen receptor (AR) signaling inhibitors have improved the treatment of castration-resistant prostate cancer (CRPC). Nonetheless, effect these drugs is often time-limited and eventually most patients become resistant due to various AR alterations. Although liquid biopsy approaches are powerful tools for early detection such therapy resistances, assays investigate only a single resistance mechanism. In combination with typically low abundance circulating biomarkers, therefore...
Metastatic prostate cancer is a highly heterogeneous and dynamic disease practicable tools for patient stratification resistance monitoring are urgently needed. Liquid biopsy analysis of circulating tumor DNA cells (CTCs) promising, but due to the diversity mechanisms, comprehensive testing essential. Previously, we demonstrated that CTCs can be characterized by mRNA-based in situ padlock probe hybridization. Now, have developed novel combinatorial dual-color (CoDuCo) approach with increased...
ABSTRACT Foetal cells are detectable in women decades postpartum, a state termed foetal microchimerism. The interplay between these semi‐allogeneic and the mother could be affected by genetic mismatches HLA loci. Here, we relate allele molecular mismatch values to presence quantity of microchimerism maternal circulation during pregnancy postpartum. A total 76 pregnant were included, which 59 followed up 1–8 years Maternal DNA was genotyped for class I II buffy coat detected qPCR, targeting...
Opting for or against the administration of adjuvant chemotherapy in therapeutic management stage II colon cancer remains challenging. Several studies report few survival benefits patients treated with therapy and additionally revealing potential side effects overtreatment, including unnecessary exposure to chemotherapy-induced toxicities reduced quality life. Predictive biomarkers are urgently needed. We, therefore, hypothesise that spatial tissue composition relapsed non-relapsed reveals...
Summary Pre-eclampsia (PE) is a syndrome that affects multiple organ systems and the most severe hypertensive disorder in pregnancy. It frequently leads to preterm delivery, maternal fetal morbidity mortality life-long complications 1 . We currently lack efficient screening tools 2, 3 early therapies 4, 5 address PE. To investigate stages of onset PE, identify candidate markers pathways, we performed spatio-temporal multi-omics profiling human PE placentae healthy controls validated targets...
Pregnant women have an increased risk of getting infected with SARS-CoV-2 and are more prone to severe illness. Data on foetal demise in affected pregnancies its underlying aetiology is scarce pathomechanisms remain largely unclear.Herein we present the case a pregnant woman COVID-19 intrauterine demise. She had no previous obstetric or gynaecological history, presented mild symptoms at 34 + 3 weeks signs distress. At 35 6 death was diagnosed. In placental histopathology evaluation, found...
Abstract Background Liquid biopsies are emerging as valuable clinical biomarkers for cancer monitoring. Despite increasing use, standardization remains a challenge. ISO and CEN/TS standardized workflows exist, but their integration into practice is underdeveloped. We aimed to assess the applicability of liquid biopsy standards in real-world setting. Methods evaluated 659 peripheral blood samples from advanced prostate patients against tracked all essential criteria. This included assessing...
Abstract Background Metastatic prostate cancer is a highly heterogeneous and dynamic disease practicable tools for patient stratification resistance monitoring are urgently needed. Liquid biopsy analysis of circulating tumor cells (CTCs) DNA promising, however, comprehensive testing essential due to diverse mechanisms resistance. Previously, we demonstrated the utility mRNA-based in situ padlock probe hybridization characterizing CTCs. Methods We have developed novel combinatorial dual-color...
Abstract Background Therapeutic management of stage II colon cancer remains difficult regarding the decision whether adjuvant chemotherapy should be administered or not. Low rates recurrence are opposed to induced toxicity and current clinical features limited in predicting disease relapse. Predictive biomarkers urgently needed we hypothesise that spatial tissue composition relapsed non-relapsed patients reveals relevant biomarkers. Methods The was examined by i n situ sequencing technology...
Hypertensive disorders in pregnancy, of which the multisystem syndrome pre-eclampsia is most severe, leading to preterm delivery, maternal mortality and life-long complications1. Pre-eclampsia lacks early screening tools2,3 causal therapies4,5. To elucidate disease dynamics, we present first spatio-temporal study comparing single-nuclei transcriptomes human pre-eclamptic placentae healthy controls, contextualising this a comprehensive including late gestational implementing spatial...