A5073565261- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Sodium Intake and Health
- Cardiovascular Issues in Pregnancy
- Nutritional Studies and Diet
- Advanced Glycation End Products research
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Obesity, Physical Activity, Diet
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Vitamin D Research Studies
- Thermoregulation and physiological responses
- Per- and polyfluoroalkyl substances research
- Breastfeeding Practices and Influences
- Eicosanoids and Hypertension Pharmacology
- Psoriasis: Treatment and Pathogenesis
- Cardiovascular Health and Disease Prevention
- Alcohol Consumption and Health Effects
- Effects and risks of endocrine disrupting chemicals
- Cardiovascular Function and Risk Factors
- Electrolyte and hormonal disorders
- Monoclonal and Polyclonal Antibodies Research
- Health, Environment, Cognitive Aging
Harvard University
2022-2025
German Institute of Human Nutrition
2020-2024
Public Health Department
2024
Brigham and Women's Hospital
2024
German Center for Diabetes Research
2020-2023
Heinrich Heine University Düsseldorf
2020-2023
Deutsches Diabetes-Zentrum e.V.
2020-2023
German Centre for Cardiovascular Research
2018-2022
Max Delbrück Center
2018-2021
Charité - Universitätsmedizin Berlin
2018-2021
The pathogenesis of left ventricular hypertrophy in patients with CKD is incompletely understood. Sodium intake, which usually assessed by measuring urinary sodium excretion, has been inconsistently linked hypertrophy. However, tissues such as skin and muscle may store sodium. Using 23sodium-magnetic resonance imaging, a technique recently developed for the assessment tissue content humans, we determined at level calf 99 mild to moderate (42 women; median [range] age, 65 [23-78] years). We...
The idea that increasing salt intake increases drinking and urine volume is widely accepted. We tested the hypothesis an increase in of 6 g/d would change fluid balance men living under ultra-long-term controlled conditions.Over course 2 separate space flight simulation studies 105 205 days' duration, we exposed 10 healthy to 3 levels (12, 9, or g/d). All other nutrients were maintained constant. studied effect salt-driven changes mineralocorticoid glucocorticoid urinary excretion on...
OBJECTIVE N-glycosylation is a functional posttranslational modification of immunoglobulins (Igs). We hypothesized that specific IgG N-glycans are associated with incident type 2 diabetes and cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS performed case-cohort studies within the population-based European Prospective Investigation into Cancer Nutrition (EPIC)–Potsdam cohort (2,127 in subcohort [741 cases]; 2,175 CVD [417 myocardial infarction stroke cases]). Relative abundances 24...
Abstract Background Advanced glycation end-products are proteins that become glycated after contact with sugars and implicated in endothelial dysfunction arterial stiffening. We aimed to investigate the relationships between advanced end-products, measured as skin autofluorescence, vascular stiffness various glycemic strata. Methods performed a cross-sectional analysis within European Prospective Investigation into Cancer Nutrition (EPIC)-Potsdam cohort, comprising n = 3535 participants...
Previous studies of association between exposure to poly- and perfluoroalkyl substances (PFAS) gestational hypertension (GH) preeclampsia (PE) have shown conflicting results, but most dichotomized outcome did not study continuous blood pressure (BP) changes.
Abstract Background Fetuin-A is a hepatokine which has the capacity to prevent vascular calcification. Moreover, it linked induction of metabolic dysfunction, insulin resistance and associated with increased risk diabetes. It not been clarified whether fetuin-A associates vascular, specifically microvascular, complications in patients We aimed investigate pre-diagnostic plasma once diabetes develops. Methods Participants incident type 2 free micro- macrovascular disease from European...
OBJECTIVE Breastfeeding duration is inversely associated with risks of cardiovascular disease (CVD) and type 2 diabetes in parous women. However, the association among women at high risk, including or gestational mellitus (GDM) unclear. RESEARCH DESIGN AND METHODS We included 15,146 from Nurses’ Health Study I II (NHS, NHS II) 4,537 a history GDM II. Participants reported breastfeeding via follow-up questionnaires. Incident CVD by 2017 comprised stroke coronary heart (CHD) (myocardial...
Preeclampsia is associated with increased cardiovascular long-term risk; however, the underlying functional and structural mechanisms are unknown. We investigated maternal cardiac alterations after preeclampsia. Female rats harboring human angiotensinogen gene [TGR(hAogen)L1623] develop a preeclamptic phenotype hypertension albuminuria during pregnancy when mated male bearing renin [TGR(hRen)L10J] but behave physiologically normal before pregnancy. Furthermore, were treated pravastatin....
Circulating N-terminal pro B-type natriuretic peptide (NT-proBNP) is a classic diagnostic and prognostic marker for heart failure. However, it inversely associated with diabetes risk. We aimed to investigate relationships of NT-proBNP risk diabetes-related complications in initially healthy individuals.We performed case-cohort study within the European Prospective Investigation Into Cancer Nutrition (EPIC)-Potsdam cohort including random subcohort (n = 1,294) incident cases type 2 649)...
The mineralocorticoid aldosterone increases in plasma healthy pregnancy along with renin and angiotensin II plays a key role the physiological volume expansion. In mice, contributes to an optimal fetal development by enhancing PlGF (placental growth factor) expression trophoblast cell proliferation. preeclampsia, there is coincident suppression of impaired placental development. We hypothesized that independently birth weight humans, high dietary sodium low potassium intakes affect this...
Pregnancy-induced hypertension is a severe pregnancy complication, increasing risk of long-term cardiovascular disease in mothers and offspring. We hypothesized that maternal blood pressure associated with offspring pressure; the associations were sex-specific; circulating placental angiogenic markers (PlGF [placental growth factor] sFlt-1 [soluble fms-like tyrosine kinase-1]) mediated this relationship. analyzed data from 2434 women 2217 children Odense Child Cohort, prospective Danish...
Evidence has indicated that polyunsaturated fatty acids (PUFAs)-enriched diet could reduce inflammation because of thyroid autoimmunity in vivo, and therefore, enhance function. We investigated whether early pregnancy plasma phospholipid PUFAs benefit maternal function across pregnancy, which is critical to fetal brain development growth pregnancy. Within the National Institute Child Health Human Development Fetal Growth Studies-Singleton Cohort, we collected samples longitudinally from 214...
Abstract Healthy dietary patterns, such as the alternate Mediterranean diet and Eating Index, benefit cardiometabolic health. However, several food components of these patterns are primary sources environmental chemicals. Here, using data from a racially ethnically diverse US cohort, we show that healthy pattern scores were positively associated with plasma chemical exposure in pregnancy, particularly for Index polychlorinated biphenyls per- poly-fluoroalkyl substances. The associations...
Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce inconclusive. We evaluated CRC intake dAGEs European Prospective Investigation into Cancer Nutrition (EPIC) study. intakes three major dAGEs: Nε-carboxy-methyllysine (CML), Nε-carboxyethyllysine (CEL),...
Preeclampsia shares numerous risk factors with cardiovascular diseases. Here, we aimed to assess the potential utility of high-sensitivity cardiac troponin I (hs-cTnI) values during pregnancy in predicting preeclampsia occurrence.
Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not previously investigated. Multivariable Cox proportional hazards models were used calculate hazard ratios corresponding 95% confidence intervals for associations between dietary intake CRC-specific all-cause among 5801 participant cases diagnosed CRC...
Several studies have shown that women with a preeclamptic pregnancy exhibit an increased risk of cardiovascular disease. However, the underlying molecular mechanisms are unknown. Animal models essential to investigate causes this and ability assess possible preventive therapeutic interventions. Using latest technologies such as speckle tracking echocardiography (STE), it is feasible map subclinical changes in cardiac diastolic systolic function well structural maternal heart. The aim work...
Early-onset obesity is known to culminate in type 2 diabetes, arterial hypertension and subsequent cardiovascular disease. The role of sodium (Na+) homeostasis this process incompletely understood, yet correlations between Na+ accumulation have been observed adults. We aimed investigate these associations adolescents. A cohort 32 adolescents (13–17 years), comprising 20 obese patients, whom 11 were hypertensive, as well 12 age-matched controls, underwent 23Na-MRI the left lower leg with a...
It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history CVD. We assessed interactions between biomarkers low PUFA and in relation to long-term CVD large consortium.
Objective: Hypertension before and during early pregnancy has been associated with an increased risk of gestational diabetes mellitus (GDM) in retrospective analyses. We aimed to investigate the prospective blood pressure trackings a population-based cohort pregnant women, who were stratified according their metabolic status third trimester. Methods: recorded longitudinally 1230 women from Odense Child Cohort, Denmark. Fasting glucose insulin measured at weeks 28–30. Metabolic was evaluated...