Joseph A. Rothwell
A5035488801- Metabolomics and Mass Spectrometry Studies
- Tea Polyphenols and Effects
- Phytochemicals and Antioxidant Activities
- Nutritional Studies and Diet
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- Phytoestrogen effects and research
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Coffee research and impacts
- Freezing and Crystallization Processes
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Meat and Animal Product Quality
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Colorectal Cancer Screening and Detection
- Fatty Acid Research and Health
- Epigenetics and DNA Methylation
- Mycotoxins in Agriculture and Food
- Microbial Inactivation Methods
- Metabolism and Genetic Disorders
- Carcinogens and Genotoxicity Assessment
- Cancer, Hypoxia, and Metabolism
- Consumer Attitudes and Food Labeling
Université de Versailles Saint-Quentin-en-Yvelines
2019-2024
Université Paris-Saclay
2019-2024
Centre de recherche en Epidémiologie et Santé des Populations
2019-2024
Inserm
2019-2024
Institut Gustave Roussy
2020-2024
Université Paris-Sud
2019-2023
Hudson Institute
2023
John Wiley & Sons (United States)
2023
Zero to Three
2022
Centre International de Recherche sur le Cancer
2013-2021
Polyphenols are a major class of bioactive phytochemicals whose consumption may play role in the prevention number chronic diseases such as cardiovascular diseases, type II diabetes and cancers. Phenol-Explorer, launched 2009, is only freely available web-based database on content polyphenols food their vivo metabolism pharmacokinetics. Here we report third release (Phenol-Explorer 3.0), which adds data effects processing polyphenol contents foods. Data >100 foods, covering 161 or groups...
Octanol−water partition coefficient (log P) values were determined for flavonoids from the flavone, flavonol, flavanone, and isoflavonoid subclasses. Each flavonoid was dissolved in an octanol−water system allowed to equilibrate, then both fractions analyzed by high-performance liquid chromatography. log P calculated as log[ratio of concentration octanol phase aqueous at pH 7.4]. The aglycons more lipophilic than any conjugate. conjugate moiety had a significant effect on aglycon moiety....
Phenol-Explorer, launched in 2009, is the only comprehensive web-based database on content foods of polyphenols, a major class food bioactives that receive considerable attention due to their role prevention diseases. Polyphenols are rarely absorbed and excreted ingested forms, but extensively metabolized body, until now, no has allowed recall identities concentrations polyphenol metabolites biofluids after consumption polyphenol-rich sources. Knowledge these essential planning experiments...
BackgroundDeoxynivalenol (DON) is a toxic fungal metabolite that frequently contaminates cereal crops. DON to animals, but the effects on humans are poorly understood, in part because exposure estimates of limited precision.ObjectivesIn this study we used U.K. adult National Diet and Nutrition Survey compare 24-hr urinary excretion with intake.MethodsOne hundred subjects were identified for each following consumption groups: low (mean, 107 g cereal/day; range, 88–125), medium 179 g/day;...
Elucidation of the relationships between genotype, diet, and health requires accurate dietary assessment. In intervention epidemiological studies, assessment usually relies on questionnaires, which are susceptible to recall bias. An alternative approach is quantify biomarkers intake in biofluids, but few such markers have been validated so far. Here we describe use metabolomics for discovery nutritional biomarkers, using citrus fruits as a case study. Three study designs were compared....
Colorectal cancer located at different anatomical subsites may have distinct etiologies and risk factors. Previous studies that examined this hypothesis yielded inconsistent results, possibly because most been of insufficient size to identify heterogeneous associations with precision.
Abstract Mitochondrial dysfunction plays critical roles in cancer development and related therapeutic response; however, exact molecular mechanisms remain unclear. Recently, alongside the discovery of mitochondrial-specific DNA methyltransferases, global site-specific methylation mitochondrial genome has been described. Investigation any functional consequences however remains unclear debated due to insufficient evidence quantitative degree frequency (mtDNA) methylation. This study uses WGBS...
Coffee contains various bioactives implicated with human health and disease risk. To accurately assess the effects of overall consumption upon disease, individual intake must be measured in large epidemiological studies. Metabolomics has emerged as a powerful approach to discover biomarkers for range foods. Here we report profiling urinary metabolome cohort study subjects search new coffee intake. Using repeated 24-hour dietary records food frequency questionnaire, 20 high consumers (183-540...
Scope The Phenol‐Explorer web database ( http://www.phenol‐explorer.eu ) was recently updated with new data on polyphenol retention due to food processing. Here, we analyze these investigate the effect of different variables content and make recommendations aimed at refining estimation intake in epidemiological studies. Methods results Data effects processing upon 161 polyphenols compiled for were analyzed structure, food, process loss. These expressed as factors (RFs), fold changes Domestic...
Abstract Background Metabolomics is a promising molecular tool to identify novel etiologic pathways leading cancer. Using targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk. Methods A nested case-control study was established within European Prospective Investigation into Cancer cohort, which included 1624 first primary incident invasive cases (with known estrogen progesterone receptor HER2 status) matched...
Abstract Background Amino acid metabolism is dysregulated in colorectal cancer patients; however, it not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk cancer. We investigated circulating relation to the European Prospective Investigation into Cancer and Nutrition (EPIC) UK Biobank cohorts. Methods Concentrations 13-21 were determined baseline fasting plasma or serum samples 654 incident cases matched controls EPIC. following adjustment for false...
Abstract Background Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are implicated in the aetiology of non-communicable diseases. Our study aimed to evaluate associations between NAFLD MetS with overall cause-specific mortality. Methods We used dietary, lifestyle, anthropometric biomarker data from a random subsample 15,784 EPIC cohort participants. was assessed using index (FLI) revised definition. Indices for dysfunction–associated (MAFLD) were calculated. The...
Phenolic acids are secondary plant metabolites that may have protective effects against oxidative stress, inflammation and cancer in experimental studies. To date, limited data exist on the quantitative intake of phenolic acids. We estimated their food sources associated lifestyle factors European Prospective Investigation into Cancer Nutrition (EPIC) study. acid intakes were for 36 037 subjects aged 35–74 years recruited between 1992 2000 ten countries using a standardised 24 h recall...
Abstract Urinary excretion of 34 dietary polyphenols and their variations according to diet other lifestyle factors were measured by tandem mass spectrometry in 475 adult participants from the European Prospective Investigation into Cancer Nutrition (EPIC) cross-sectional study. A single 24-hour urine sample was analysed for each subject 4 countries. The highest median levels observed phenolic acids such as 4-hydroxyphenylacetic acid (157 μmol/24 h), followed 3-hydroxyphenylacetic, ferulic,...
Scope The Phenol‐Explorer web database details 383 polyphenol metabolites identified in human and animal biofluids from 221 publications. Here, we exploit these data to characterize visualize the metabolome, set of all derived phenolic food components. Methods results Qualitative quantitative on as described 424 intervention studies were systematically analyzed. Of metabolites, 301 without prior enzymatic hydrolysis biofluids, included glucuronide sulfate esters, glycosides, aglycones, O...
Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations HCC is derived mostly from case-control designs, with sparse information prospective cohorts. Our objective was to apply comprehensive metabolite profiling detect metabolites whose serum concentrations are associated development, using biological samples within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (>520 000 participants), where...
Abstract Background Coffee has been consistently associated with lower risk of liver cancer and chronic disease, suggesting that coffee affects mechanisms underlying disease development. Methods We measured serum metabolites using untargeted metabolomics in 1:1 matched nested case-control studies (n = 221 cases) fatal 242 the Alpha-Tocopherol, Beta-Carotene Cancer Prevention cohort 29 133). Associations between baseline drinking were identified linear regression; conditional logistic...
Abstract Background Perturbations in circulating metabolites prior to a breast cancer diagnosis are not well characterised. We aimed gain more detailed knowledge help understand and prevent the disease. Methods Baseline plasma samples from 791 cases matched controls E3N (EPIC-France) cohort were profiled by nuclear magnetic resonance (NMR)-based untargeted metabolomics. Partial least-squares discriminant analysis (PLS-DA) models built NMR profiles predict disease outcome, odds ratios false...
Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis animal models. However, epidemiological evidence on the potential role of flavonoid intake (CRC) development remains sparse inconsistent. We evaluated association between dietary intakes total flavonoids their subclasses risk CRC, within European Prospective Investigation into Cancer Nutrition (EPIC) study. A cohort 477,312 adult men women were recruited 10 countries....