Elom K. Aglago
A5073106549- Nutritional Studies and Diet
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Nutrition and Health in Aging
- Digestive system and related health
- Fatty Acid Research and Health
- Advanced Glycation End Products research
- Child Nutrition and Water Access
- Consumer Attitudes and Food Labeling
- Alcohol Consumption and Health Effects
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Plant-based Medicinal Research
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Iron Metabolism and Disorders
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Animal testing and alternatives
- Vitamin D Research Studies
- Antioxidant Activity and Oxidative Stress
- Trace Elements in Health
- Cancer Risks and Factors
- Food Security and Health in Diverse Populations
Imperial College London
2022-2025
Centre International de Recherche sur le Cancer
2017-2025
University of Kara
2021-2024
National Institute for Health Research
2021-2023
Hudson Institute
2023
John Wiley & Sons (United States)
2023
University of Cambridge
2021-2023
Health Data Research UK
2021-2023
Medical Research Council
2021-2023
British Heart Foundation
2021-2023
BackgroundRandomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability results to individuals with low status is unclear. We aimed characterise dose-response relationships between 25-hydroxyvitamin (25[OH]D) concentrations risk coronary heart disease, stroke, in observational Mendelian randomisation frameworks.MethodsObservational analyses were undertaken using data from 33 prospective...
It is currently unknown whether ultra-processed foods (UPFs) consumption associated with a higher incidence of multimorbidity. We examined the relationship total and subgroup UPFs risk multimorbidity defined as co-occurrence at least two chronic diseases in an individual among first cancer any site, cardiovascular disease, type 2 diabetes.
Abstract Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices complement body mass index (BMI) when assessing all-cause mortality. used data from 352,985 participants in European Prospective Investigation into Cancer Nutrition (EPIC) Cox proportional hazards models adjusted for other risk factors. During a mean follow-up 16.1 years, 38,178 died....
To investigate the perceived effects of coronavirus disease (COVID-19) pandemic lockdown measures on food availability, accessibility, dietary practices and strategies used by participants to cope with these measures.
Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable behaviours bear potential to minimize long-term CRC risk; however, translation of information into individualized assessment has not implemented. Lifestyle-based models may aid the identification high-risk individuals, guide referral screening motivate behaviour change. We therefore developed validated a lifestyle-based prediction algorithm in an asymptomatic European population.
BackgroundRandomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability results to individuals with low status is unclear. We aimed characterise dose-response relationships between 25-hydroxyvitamin (25[OH]D) concentrations risk coronary heart disease, stroke, in observational Mendelian randomisation frameworks.MethodsObservational analyses were undertaken using data from 33 prospective...
Abstract Background Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are implicated in the aetiology of non-communicable diseases. Our study aimed to evaluate associations between NAFLD MetS with overall cause-specific mortality. Methods We used dietary, lifestyle, anthropometric biomarker data from a random subsample 15,784 EPIC cohort participants. was assessed using index (FLI) revised definition. Indices for dysfunction–associated (MAFLD) were calculated. The...
Dicarbonyl compounds such as methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG) are present in numerous foods. They pro-inflammatory pro-oxidative, but their potential role cardiovascular disease (CVD) development has been scarcely studied. We explored associations between dietary dicarbonyls with fatal non-fatal CVD. conducted a case-cohort analysis based on 32 873 subjects drawn from 346 055 participants of the multi-national prospective EPIC cohort. Cases (15 863 subjects)...
Experimental evidence has implicated genotoxic Escherichia coli (E. coli) and enterotoxigenic Bacteroides fragilis (ETBF) in the development of colorectal cancer (CRC). However, from epidemiological studies is sparse. We therefore assessed association serological markers E. ETBF exposure with odds developing CRC European Prospective Investigation into Nutrition Cancer (EPIC) study.Serum samples incident cases matched controls (n = 442 pairs) were analyzed for immunoglobulin (Ig) A G antibody...
Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated dietary estimates plasma levels of individual total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), ruminant-sourced (rTFA) acids, CRC in European Prospective Investigation into Cancer Nutrition (EPIC). Baseline acid intakes were estimated 450 112 participants (6162 developed CRC, median follow-up = 15 years). In a nested...
Abstract Background Traditional body-shape indices such as Waist Circumference (WC), Hip (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but correlated Body Mass Index (BMI), adjustment for BMI introduces a strong correlation height. Thus, new allometric have been developed, namely A Shape (ABSI), (HI), (WHI), which uncorrelated weight height; these also CRC risk in observational studies, information from Mendelian randomization (MR) studies is missing....
Abstract Background Waist circumference (WC) and its allometric counterpart, “a body shape index” (ABSI), are risk factors for colorectal cancer (CRC); however, it is uncertain whether associations with these measurements limited to specific molecular subtypes of the disease. Methods Data from 2,772 CRC cases 3,521 controls were pooled four cohort studies within Genetics Epidemiology Colorectal Cancer Consortium. Four markers (BRAF mutation, KRAS CpG island methylator phenotype,...
Abstract We assessed hepatocellular carcinoma (HCC) risk associated with smoking and alcohol consumption their interactions, using both questionnaire data objective serum biomarkers. Information on was collected at baseline from 450,112 participants of the EPIC cohort, among whom 255 developed HCC after a median follow‐up 14 years. In nested case–control subset 108 cases matched controls, known biomarkers (cotinine, nicotine) habitual (2‐hydroxy‐3‐methylbutyric acid) were annotated...
<p>Association between waist circumference, proximal colon cancer, and its molecular subtypes.</p>
<p>Summary of study-specific assessment microsatellite instability (MSI) status.</p>
<p>Association between ABSI, colorectal cancer, and its molecular subtypes after conducting multiple imputation.</p>
<p>Association between waist circumference, colorectal cancer, and its molecular subtypes after conducting multiple imputation.</p>
<p>Association between waist circumference, distal colon cancer, and its molecular subtypes.</p>
<p>Association between A Body Shape Index (ABSI), distal colon cancer, and its molecular subtypes.</p>