A5064472857- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Nutritional Studies and Diet
- Diet and metabolism studies
- Nutrition, Health and Food Behavior
- Metabolomics and Mass Spectrometry Studies
- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- Hepatitis B Virus Studies
- Food Security and Health in Diverse Populations
- Escherichia coli research studies
- Galectins and Cancer Biology
- Medical and Agricultural Research Studies
- Bone health and osteoporosis research
- Clostridium difficile and Clostridium perfringens research
- Nutrition, Genetics, and Disease
- Dental Health and Care Utilization
- Vitamin D Research Studies
- Cervical Cancer and HPV Research
- Liver Disease Diagnosis and Treatment
- Veterinary medicine and infectious diseases
- Oral health in cancer treatment
- Oral microbiology and periodontitis research
- Global Cancer Incidence and Screening
- Gastrointestinal motility and disorders
National Cancer Institute
2023-2025
Division of Cancer Epidemiology and Genetics
2023-2025
National Institutes of Health
2024
Centre International de Recherche sur le Cancer
2018-2022
Abstract Aims/hypothesis The gut microbiome is hypothesised to be related insulin resistance and other metabolic variables. However, data from population-based studies are limited. We investigated associations between serologic measures of health the in Northern Finland Birth Cohort 1966 (NFBC1966) TwinsUK cohort. Methods Among 506 individuals NFBC1966 with available faecal (16S rRNA gene sequence) data, we estimated diversity metrics levels HOMA for (HOMA-IR), HbA 1c C-reactive protein...
Experimental evidence has implicated genotoxic Escherichia coli (E. coli) and enterotoxigenic Bacteroides fragilis (ETBF) in the development of colorectal cancer (CRC). However, from epidemiological studies is sparse. We therefore assessed association serological markers E. ETBF exposure with odds developing CRC European Prospective Investigation into Nutrition Cancer (EPIC) study.Serum samples incident cases matched controls (n = 442 pairs) were analyzed for immunoglobulin (Ig) A G antibody...
Abstract Background: Biological factors impact the human microbiome, highlighting need for reasonably estimating sample sizes in future population studies. Methods: We assessed temporal stability of fecal microbiome diversity, species composition, and genes functional pathways through shallow shotgun metagenome sequencing. Using intraclass correlation coefficients (ICC), we measured biological variability over six months. estimated case numbers 1:1 or 1:3 matched case-control studies,...
Importance Calcium intake is associated with a reduced risk of colorectal cancer (CRC), although it remains unclear whether this association varies by calcium source or tumor site. Moreover, there are disparities in race and ethnicity, but the impact low consumption on CRC specific racial ethnic populations unclear. Objective To investigate between risk, considering site across groups. Design, Setting, Participants This cohort study analyzed data from National Institutes Health–AARP Diet...
Abstract Background Oral microbes detected in feces have been associated with colorectal cancer (CRC) cross‐sectional studies. This study investigated the prospective associations between oral microbiome and incident CRC Agricultural Health Study (AHS), National Institutes of Health–AARP (NIH‐AARP) Diet Study, Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Trial. Methods Individuals samples collected before diagnoses were identified AHS ( N = 331), NIH‐AARP 249), PLCO 446)...
<div>AbstractBackground:<p>Biological factors affect the human microbiome, highlighting need for reasonably estimating sample sizes in future population studies.</p>Methods:<p>We assessed temporal stability of fecal microbiome diversity, species composition, and genes functional pathways through shallow shotgun metagenome sequencing. Using intraclass correlation coefficients (ICC), we measured biological variability over 6 months. We estimated case numbers 1:1 or 1:3...
Abstract Background Dietary intake influences gut microbiome composition, which in turn may be associated with colorectal cancer (CRC). Associations of the carcinogenesis mediated through bacterially regulated, metabolically active metabolites, including trimethylamine N‐oxide (TMAO) and its precursors, choline, L‐ carnitine, betaine. Methods Prospective associations circulating TMAO precursors CRC risk were investigated. TMAO, betaine, L ‐carnitine measured baseline serum samples from 761...
We investigated associations of habitual dietary intake with the taxonomic composition and diversity human gut microbiota in 222 Koreans aged 18-58 years a cross-sectional study. Gut data were obtained by 16S rRNA gene sequencing on DNA extracted from fecal samples. The diet for previous year was assessed food frequency questionnaire. After multivariable adjustment, several groups including vegetables, fermented legumes, dairy products, processed meat, non-alcoholic beverages associated...