Vivian Viallon
A5060396702- Cancer Risks and Factors
- Statistical Methods and Inference
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- Metabolism, Diabetes, and Cancer
- Bayesian Methods and Mixture Models
- Statistical Methods and Bayesian Inference
- Advanced Causal Inference Techniques
- Diet and metabolism studies
- Gene expression and cancer classification
- Liver Disease Diagnosis and Treatment
- Biotechnology and Related Fields
- Advanced Statistical Methods and Models
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Nutrition and Health in Aging
- Traffic and Road Safety
- Estrogen and related hormone effects
- Infant Nutrition and Health
- Advanced Proteomics Techniques and Applications
- Consumer Attitudes and Food Labeling
- Alcohol Consumption and Health Effects
- Machine Learning and Data Classification
- Health, Medicine and Society
Centre International de Recherche sur le Cancer
2017-2025
Massachusetts Institute of Technology
2023
The University of Melbourne
2023
University of Kansas Medical Center
2023
Cancer Council Victoria
2023
Murdoch Children's Research Institute
2023
Imperial College London
2023
Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement
2011-2018
Université Claude Bernard Lyon 1
2012-2018
Hôpital Cochin
2008-2014
Abstract Background Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has scarcely investigated. The aim this study was investigate associations between five and incident multimorbidity cancer cardiometabolic diseases. Methods In prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 58 years free cancer,...
Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk unknown and has been understudied in European populations to date.
It is currently unknown whether ultra-processed foods (UPFs) consumption associated with a higher incidence of multimorbidity. We examined the relationship total and subgroup UPFs risk multimorbidity defined as co-occurrence at least two chronic diseases in an individual among first cancer any site, cardiovascular disease, type 2 diabetes.
BackgroundFood processing has been hypothesised to play a role in cancer development; however, data from large-scale epidemiological studies are scarce. This study investigated the association between dietary intake according amount of food and risk at 25 anatomical sites using European Prospective Investigation into Cancer Nutrition (EPIC) study.MethodsThis used prospective EPIC cohort study, which recruited participants March 18, 1991, July 2, 2001, 23 centres ten countries. Participant...
Objective: Septic shock is a severe, often terminal, complication of malignancy. For patients without malignancy, outcome from septic has improved with new advances in care. We wished to explore whether similarly for cancer patients, regard implementation recent adjuvant therapies. Design: An 8-yr retrospective observational study. Setting: A 24-bed medical intensive care unit university hospital. Patients: Patients were 238 consecutive (solid tumors or hematologic malignancies) admitted the...
We investigate fast methods that allow to quickly eliminate variables (features) in supervised learning problems involving a convex loss function and $l_1$-norm penalty, leading potentially substantial reduction the number of prior running algorithm. The are not heuristic: they only features {\em guaranteed} be absent after solving problem. Our framework applies large class problems, including support vector machine classification, logistic regression least-squares. complexity feature...
Intestinal bacterial colonisation in pre-term infants is delayed compared with full-term infants, leading to an increased risk of gastrointestinal disease. Modulation through dietary supplementation probiotics or prebiotics could decrease such a risk. The present study evaluated clinical tolerance, the effects on gut microbiota, and inflammatory immunological mucosal responses infant formula adapted for that included its manufacturing process fermentation step two probiotic strains,...
This research aims to estimate the relative risks of responsibility for a fatal accident linked driving under influence cannabis or alcohol, prevalence these influences among drivers and corresponding attributable risk ratios. A secondary goal is same items three other groups illicit drugs (amphetamines, cocaine opiates), compare results similar study carried out in France between 2001 2003. Police procedures accidents Metropolitan during 2011 were analyzed 300 characteristics encoded...
In the present work, we aim to transfer field of virtual screening predictiveness curve, a metric that has been advocated in clinical epidemiology. The literature describes use curves evaluate performances biological markers formulate diagnoses, prognoses and assess disease risks, fit risk models, estimate utility model when applied population. Similarly, logistic regression models calculate activity probabilities related scores compounds obtained experiments. curve can provide an intuitive...
Abstract Background Metabolomics is a promising molecular tool to identify novel etiologic pathways leading cancer. Using targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk. Methods A nested case-control study was established within European Prospective Investigation into Cancer cohort, which included 1624 first primary incident invasive cases (with known estrogen progesterone receptor HER2 status) matched...
Single body mass index (BMI) measurements have been associated with increased risk of 13 cancers. Whether life course adiposity-related exposures are more relevant cancer factors than baseline BMI (ie, at start follow-up for disease outcome) remains unclear. We conducted a cohort study from 2009 until 2018 population-based electronic health records in Catalonia, Spain. included 2,645,885 individuals aged ≥40 years and free 2009. After 9 follow-up, 225,396 participants were diagnosed cancer....
Abstract Background Amino acid metabolism is dysregulated in colorectal cancer patients; however, it not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk cancer. We investigated circulating relation to the European Prospective Investigation into Cancer and Nutrition (EPIC) UK Biobank cohorts. Methods Concentrations 13-21 were determined baseline fasting plasma or serum samples 654 incident cases matched controls EPIC. following adjustment for false...
Abstract Background Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are implicated in the aetiology of non-communicable diseases. Our study aimed to evaluate associations between NAFLD MetS with overall cause-specific mortality. Methods We used dietary, lifestyle, anthropometric biomarker data from a random subsample 15,784 EPIC cohort participants. was assessed using index (FLI) revised definition. Indices for dysfunction–associated (MAFLD) were calculated. The...
We describe a fast method to eliminate features (variables) in l1 -penalized least-square regression (or LASSO) problems. The elimination of leads potentially substantial reduction running time, specially for large values the penalty parameter. Our is not heuristic: it only eliminates that are guaranteed be absent after solving LASSO problem. feature step easy parallelize and can test each independently. Moreover, computational effort our negligible compared problem - roughly same as single...
To investigate whether the glycosylation and sialylation levels of anti-proteinase 3 (anti-PR3) antibodies could affect their pathogenicity, these be correlated with activity granulomatosis polyangiitis (Wegener's) (GPA).Forty-two serum samples positive for anti-PR3 from 42 patients active or weakly active/inactive GPA were included. Anti-PR3 assayed by enzyme-linked immunosorbent assay, assessed lectin assay. The IgG purified healthy donors active, remitted, disease permethylation mass...
Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations HCC is derived mostly from case-control designs, with sparse information prospective cohorts. Our objective was to apply comprehensive metabolite profiling detect metabolites whose serum concentrations are associated development, using biological samples within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (>520 000 participants), where...
Abstract Background Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological Mendelian randomization (MR) analyses investigate whether alterations in circulating levels bilirubin are associated with risk colorectal (CRC). decided priori perform separately men women based on suggestive evidence that associations may differ by sex. Methods In case-control study nested the European Prospective...
Abstract Aims/hypothesis The gut microbiome is hypothesised to be related insulin resistance and other metabolic variables. However, data from population-based studies are limited. We investigated associations between serologic measures of health the in Northern Finland Birth Cohort 1966 (NFBC1966) TwinsUK cohort. Methods Among 506 individuals NFBC1966 with available faecal (16S rRNA gene sequence) data, we estimated diversity metrics levels HOMA for (HOMA-IR), HbA 1c C-reactive protein...
ABSTRACT This study aimed to determine cutoff levels for fecal calprotectin as a marker of intestinal distress in preterm neonates. A total 126 infants born at median gestational age 33 weeks (range 25.7–35 weeks) were enrolled. Samples (n = 312) collected weekly from the end first week life until month and if any gastrointestinal event occurred. Receiver operating characteristic curves analysis gave values 363 μg/g (sensitivity 0.65, specificity 0.82) 636 0.72, 0.95) development mild or...
<h3>Objective</h3> There is increasing interest in adding common genetic variants identified through genome wide association studies (GWAS) to breast cancer risk prediction models. First results from such models showed modest benefits terms of discrimination. Heterogeneity as defined by hormone-receptor status has not been considered this context. In study we investigated the predictive capacity 32 GWAS-detected for risk, alone and combination with classical factors, tumours different...