A5069387998- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Organ Donation and Transplantation
- Respiratory Support and Mechanisms
- Pneumonia and Respiratory Infections
- Cardiac, Anesthesia and Surgical Outcomes
- Palliative Care and End-of-Life Issues
- Mechanical Circulatory Support Devices
- Hemodynamic Monitoring and Therapy
- Thermal Regulation in Medicine
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Traumatic Brain Injury Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Nosocomial Infections in ICU
- Organ Transplantation Techniques and Outcomes
- Heart Failure Treatment and Management
- Grief, Bereavement, and Mental Health
- Trauma and Emergency Care Studies
- COVID-19 Clinical Research Studies
- Family and Patient Care in Intensive Care Units
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Heart Rate Variability and Autonomic Control
Hôpital Cochin
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Paris Cité
2014-2025
University Hospital Heidelberg
2024
Heidelberg University
2024
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2007-2023
University of Liège
2023
Hôpital Marie Lannelongue
2021
Hôpital Paris Saint-Joseph
2021
Sorbonne Paris Cité
2012-2018
To investigate the value of brain natriuretic peptide plasma levels as a marker systolic myocardial dysfunction during severe sepsis and septic shock.Prospective observational study.Intensive care unit.A total 34 consecutive patients with (nine patients) or shock (25 without previous cardiac, respiratory, chronic renal failure.None.Myocardial performance was assessed by fractional area contraction (FAC) using echocardiography performed on days 2 (FACD2) 8. Plasma were measured at 1-4 8 after...
Background— Although the level of evidence improvement is significant in cardiac arrest patients resuscitated from a shockable rhythm (ventricular fibrillation or pulseless ventricular tachycardia [VF/V t ]), use therapeutic mild hypothermia (TMH) more controversial nonshockable (pulseless electric activity asystole [PEA/asystole]). We therefore assessed prognostic value for neurological outcome at hospital discharge according to first-recorded large cohort. Methods and Results— Between...
Abstract Background Most studies about septic shock report a crude mortality rate that neither distinguishes between early and late deaths nor addresses the direct causes of death. We herein aimed to determine modalities death in shock. Methods This was 6-year (2008–2013) monocenter retrospective study. All consecutive patients diagnosed for within first 48 h intensive care unit (ICU) admission were included. Early defined as occurring or after 3 days following ICU admission, respectively....
To identify factors associated with mortality and morbidity among adults admitted to intensive care units (ICUs) for pneumococcal meningitis, particularly the impact of delayed antibiotic administration.We conducted a prospective, multicenter, observational study 156 consecutive hospitalized meningitis. We analyzed parameters 3-month survival.Fifty-six medical medical-surgical ICUs in France.None.Of 148 strains isolated, 56 (38%) were nonsusceptible penicillin G. At 3 months after ICU...
Objective: Septic shock is a severe, often terminal, complication of malignancy. For patients without malignancy, outcome from septic has improved with new advances in care. We wished to explore whether similarly for cancer patients, regard implementation recent adjuvant therapies. Design: An 8-yr retrospective observational study. Setting: A 24-bed medical intensive care unit university hospital. Patients: Patients were 238 consecutive (solid tumors or hematologic malignancies) admitted the...
Objective Few outcome data are available about posterior reversible encephalopathy syndrome (PRES). We studied 90-day functional outcomes and their determinants in patients with severe PRES. Design 70 PRES admitted to 24 ICUs 2001–2010 were included a retrospective cohort study. The main measure was Glasgow Outcome Scale (GOS) of 5 (good recovery) on day 90. Main Results Consciousness impairment the most common clinical sign, occurring 66 (94%) patients. Clinical seizures occurred 57 (81%)...
Objectives: Infectious complications are frequently reported in critically ill patients, especially after cardiac arrest. Recent and widespread use of therapeutic hypothermia has raised concerns about increased septic complications, but no specific reappraisal been performed. We investigated the infectious arrest survivors assessed their impact on morbidity long-term outcome. Design: Retrospective review a prospectively acquired intensive care unit database. Setting: A 24-bed medical French...
Rationale: Although intensive care units (ICUs) were created for patients with life-threatening illnesses, the ICU environment generates a high risk of iatrogenic events. Identifying medical errors (MEs) that serve as indicators is crucial purposes reporting and prevention.Objectives: We describe selection indicator MEs, incidence such their relationship mortality.Methods: selected MEs using Delphi techniques. An observational prospective multicenter cohort study these was conducted from...
Targeted temperature management is recommended after out-of-hospital cardiac arrest. Whether advanced internal cooling superior to basic external remains unknown. The aim of this multicenter, controlled trial was evaluate the benefit endovascular versus surface cooling.Inclusion criteria were following: age 18 79 years, arrest related a presumed cause, time return spontaneous circulation <60 minutes, delay between and inclusion <240 unconscious patient before start cooling. Exclusion...
Septic shock is a frequent and severe complication in the course of malignancies. In large multicenter cohort septic patients with hematologic malignancies solid tumors, we assessed temporal trend survival prognostic factors, particular emphasis on case volume.A 12-yr retrospective study prospectively collected data.Cancer were selected over period (1997-2008) from French regional database (CUB-Réa). The following variables extracted: demographic characteristics, type malignancy,...
Improving timeliness of pathogen identification is crucial to allow early adaptation antibiotic therapy and improve prognosis in patients with pneumonia. We evaluated the relevance a new syndromic rapid multiplex PCR test (rm-PCR) on respiratory samples guide empirical antimicrobial adult community-acquired pneumonia (CAP), hospital-acquired (HAP), ventilator-acquired (VAP).This retrospective multicenter study was conducted four French university hospitals. Respiratory were obtained from...
The aim of this study is to determine whether severe COVID-19 patients harbour a higher risk ICU-acquired pneumonia.This retrospective multicentre cohort comprised all consecutive admitted seven ICUs for pneumonia during the first surge in France. Inclusion criteria were laboratory-confirmed SARS-CoV-2 infection and requirement invasive mechanical ventilation 48 h or more. Control groups two historical cohorts mechanically ventilated ICU bacterial non-SARS-CoV-2 viral pneumonia. outcome...
After cardiac arrest (CA), the European recommendations suggest to use a neuron-specific enolase (NSE) level > 60 µg/L at 48-72 h predict poor outcome. However, prognostic performance of NSE can vary depending on electroencephalogram (EEG). The objective was determine whether threshold which predicts outcome varies according EEG patterns and effect electrographic seizures level. A retrospective study conducted in tertiary CA center, using prospective registry 155 adult patients comatose 72...
Community-acquired pneumonia (CAP) account for a high proportion of ICU admissions, with Streptococcus pneumoniae being the main pathogen responsible these infections. However, little is known on clinical features and outcomes patients pneumococcal pneumonia. The aims this study were to provide epidemiological data determine risk factors mortality in admitted severe S. CAP.We performed retrospective review two prospectively-acquired multicentre databases (2001-2008). Patients management CAP...
Objectives: Although sudden cardiac death has been broadly studied, little is known on cerebrovascular events revealed by out-of-hospital arrest. We aimed to describe clinical features and prognosis of these patients identify characteristics that could suggest a etiology the Design: Retrospective review (1999–2012) databases three regional referral ICU centers for Setting: Patients admitted management successfully resuscitated Patients: were included when subarachnoid hemorrhage,...
Thyroid storm represents a rare but life-threatening endocrine emergency. Only data are available on its management and the outcome of most severe forms requiring ICU admission. We aimed to describe clinical manifestations, in-ICU 6-month survival rates patients with those thyroid admission.Retrospective, multicenter, national study over an 18-year period (2000-2017).Thirty-one French ICUs.The local medical records from each participating were screened using International Classification...