A5025809606- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Delphi Technique in Research
- Vasculitis and related conditions
- Cancer Immunotherapy and Biomarkers
- Ethics in Clinical Research
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Clinical practice guidelines implementation
- Intensive Care Unit Cognitive Disorders
- Advanced Causal Inference Techniques
- Long-Term Effects of COVID-19
- Health Policy Implementation Science
- COVID-19 and healthcare impacts
- Acute Kidney Injury Research
- Healthcare cost, quality, practices
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pregnancy and Medication Impact
- Cardiac Arrest and Resuscitation
- Platelet Disorders and Treatments
- Family and Patient Care in Intensive Care Units
- Telemedicine and Telehealth Implementation
- Total Knee Arthroplasty Outcomes
- Otitis Media and Relapsing Polychondritis
Inserm
2015-2024
Sorbonne Université
2018-2024
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2018-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Pitié-Salpêtrière Hospital
2018-2024
Sorbonne University Abu Dhabi
2023
Hôpital Charles-Foix
2019-2021
Centre de Neurophysique Physiologie et Pathologie
2021
Collaborative Group (United States)
2021
Université Sorbonne Nouvelle
2021
Background: A recent study suggested that results of single-center trials are frequently contradicted when similar performed in multicenter settings. Purpose: To perform a meta-epidemiologic to evaluate whether estimates treatment effect differ between and randomized, controlled (RCTs). Data Sources: MEDLINE was searched via PubMed for meta-analyses RCTs with binary outcomes were published August 2008 January 2009 the first 6 months 2010 10 leading journals each medical specialty. One issue...
Agnes Dechartres and colleagues searched ClinicalTrials.gov for completed drug RCTs with results reported then corresponding studies in PubMed to evaluate timeliness completeness of reporting. Please see later the article Editors' Summary
<h3>Background</h3> Epidemiology of spontaneous pneumothorax has been scantily studied. We aimed to assess the incidence and describe patients' characteristics with respect age, sex, seasonal occurrence, primary or secondary character, surgical management rehospitalisations on a large-scale database. <h3>Methods</h3> Data from all patients aged ≥14 years hospitalised diagnosis non-traumatic in France 2008 2011 were retrieved National Hospitalisation Database. <h3>Results</h3> There 59 637...
Abstract Background Most studies about septic shock report a crude mortality rate that neither distinguishes between early and late deaths nor addresses the direct causes of death. We herein aimed to determine modalities death in shock. Methods This was 6-year (2008–2013) monocenter retrospective study. All consecutive patients diagnosed for within first 48 h intensive care unit (ICU) admission were included. Early defined as occurring or after 3 days following ICU admission, respectively....
<h3>Importance</h3> A persistent dilemma when performing meta-analyses is whether all available trials should be included in the meta-analysis. <h3>Objectives</h3> To compare treatment outcomes estimated by meta-analysis of and several alternative analytic strategies: single most precise trial (ie, with narrowest confidence interval), restricted to 25% largest trials, limit (a model adjusted for small-study effect), at low overall risk bias. <h3>Data Sources</h3> One hundred sixty-three...
Summary Patients with common variable immunodeficiency (CVID) are at high risk of developing immune thrombocytopenia (ITP) and/or autoimmune haemolytic anaemia (AHA). Given their underlying immunodeficiency, immunosuppressive treatment these manifestations may increase the infection. To assess efficacy and safety rituximab in patients CVID‐associated ITP/AHA, a multicentre retrospective study was performed. Thirty‐three patients, 29 adults four children, were included. received an average...
<b>Objective</b> To assess the waste of research related to inadequate methods in trials included Cochrane reviews and examine what extent this could be avoided. A secondary objective was perform a simulation study re-estimate avoidable if all were adequately reported. <b>Design</b> Methodological review study. <b>Data sources</b> Trials meta-analysis primary outcome published between April 2012 March 2013. extraction synthesis</b> We collected risk bias assessment made by authors for each...
Objective Data on adult IgA vasculitis (Henoch‐Schönlein) (IgAV) are scarce. This survey was designed to better define the clinical spectrum of IgAV and efficacy treatments in a French patient population. Methods characteristics, histologic features, treatment response from 260 patients with included multicenter retrospective were analyzed. Efficacy data compared using different statistical models. Results The mean ± SD age at diagnosis 50.1 18 years, 63% male. Baseline manifestations...
<b>Objective</b> To examine how poor reporting and inadequate methods for key methodological features in randomised controlled trials (RCTs) have changed over the past three decades. <b>Design</b> Mapping of included Cochrane reviews. <b>Data sources</b> Data from RCTs all reviews published between March 2011 September 2014 an evaluation risk bias items: sequence generation, allocation concealment, blinding, incomplete outcome data. extraction</b> For each RCT, we...
The reporting of serious adverse events (SAEs) in clinical trials is crucial to assess the balance between benefits and risks. For with posted at ClinicalTrials.gov, we assessed consistency SAEs ClinicalTrials.gov those published corresponding journal articles.All records from up February 2014 were automatically exported XML format. Among these, identified all phase III or IV randomized controlled least one SAE posted. a random sample 300 these trials, searched for publications using MEDLINE...
Little is known concerning mortality and predictive factors for anorexia nervosa in-patients. This study aimed to establish rates identify predictors in a large sample of adults through 10-year post in-patient treatment follow-up.Vital status was established 601 (DSM-IV) consecutive in-patients with initial evaluation at admission. Standardized ratio (SMR) calculated. Cox analyses hypothesized were performed.Forty deaths recorded. SMR 10.6 [CI 95% (7.6-14.4)]. Six admission associated death:...