A5041902083- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Autoimmune Bullous Skin Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genetic and Kidney Cyst Diseases
- Pregnancy and Medication Impact
- Liver Diseases and Immunity
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Complement system in diseases
- Renal and related cancers
- Civil and Structural Engineering Research
- Metabolism and Genetic Disorders
- Renal and Vascular Pathologies
- Atherosclerosis and Cardiovascular Diseases
- Amino Acid Enzymes and Metabolism
- Systemic Sclerosis and Related Diseases
- Chronic Lymphocytic Leukemia Research
- Pharmacological Effects of Natural Compounds
- Concrete Corrosion and Durability
- Bipolar Disorder and Treatment
- Blood groups and transfusion
- Sarcoidosis and Beryllium Toxicity Research
- Immunodeficiency and Autoimmune Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
Fleury S.A. (Brazil)
2025
Hôpital Necker-Enfants Malades
2015-2024
Assistance Publique – Hôpitaux de Paris
2014-2024
Leipzig University
2024
Institut des Maladies Génétiques Imagine
2018-2023
Inserm
2003-2023
Collaborative Group (United States)
2023
University of Zurich
2023
Université Paris Cité
2003-2022
Institut Necker Enfants Malades
2016-2022
Immune rejection of organ transplants is a life-threatening complication and exemplified by alterations in the expression protein-encoding genes. Because microRNAs (miRNAs) regulate genes implicated adaptive immunity, we investigated whether acute (AR) associated with miRNA within allografts profiles are diagnostic AR predict allograft function. Seven 33 renal biopsies (12 21 normal) were profiled using microfluidic cards containing 365 mature human miRNAs (training set), subset...
Summary Background and objectives Renal infarction is an arterial vascular event that may cause irreversible damage to kidney tissues. This study describes the clinical characteristics of patients with renal according underlying mechanism injury. Design, setting, participants, & measurements retrospectively identified 94 diagnosed between 1989 2011 aim highlighting potential correlations demographic, clinical, biologic etiology infarction. Four groups were identified: cardiac origin...
Objective Data on adult IgA vasculitis (Henoch‐Schönlein) (IgAV) are scarce. This survey was designed to better define the clinical spectrum of IgAV and efficacy treatments in a French patient population. Methods characteristics, histologic features, treatment response from 260 patients with included multicenter retrospective were analyzed. Efficacy data compared using different statistical models. Results The mean ± SD age at diagnosis 50.1 18 years, 63% male. Baseline manifestations...
Objectives Lupus nephritis (LN) is a frequent complication of systemic lupus erythematosus (SLE). Severe (proliferative) forms LN are treated with induction immunosuppressive therapy (IST), followed by maintenance IST, to target remission and avoid relapses. The optimal duration IST unknown. WIN-Lupus trial tested whether discontinuation after 2‒3 years was non-inferior continuation for two more in proliferative LN. Methods an investigator-initiated multicentre randomised controlled trial....
A therapeutic strategy based on complement blockade by eculizumab is widely used to treat atypical haemolytic uraemic syndrome (aHUS). Recent data are available the administration of during pregnancy in patients treated for paroxysmal nocturnal haemoglobinuria but there very few aHUS patients.We analysed use treatment five pregnancies three and studied an additional without eculizumab. Obstetrical maternal foetal complications pregnancy, at delivery, post-partum period were recorded.The mean...
Renal involvement is a rare event during primary SS (pSS). We aimed to describe the clinico-biological and histopathological characteristics of pSS-related nephropathy its response treatment.We conducted French nationwide, retrospective, multicentre study including pSS patients fulfilling American-European Consensus Group criteria or enlarged criteria, with biopsy-proven renal involvement.A total 95 were included (median age 49 years). An estimated glomerular filtration rate (eGFR) <60...
Data from the PEXIVAS trial challenged role of plasma exchange (PLEX) in ANCA-associated vasculitides (AAV). We aimed to describe kidney biopsy patients with AAV treated PLEX, evaluate whether histopathologic findings could predict function, and identify which would most benefit PLEX.We performed a multicenter, retrospective study on 188 AKI PLEX 237 not PLEX. The primary outcome was mortality or KRT at 12 months (M12).No significant for found. To benefitting we developed model predicting...
Abstract Objectives The specific roles of remission status, lupus low disease activity state (LLDAS), and damage accrual on the prognosis pregnancies in women with SLE are unknown. We analysed their impact maternal flares adverse pregnancy outcomes (APOs). Methods evaluated all (≥18 years) enrolled prospective GR2 study an ongoing singleton at 12 weeks (one pregnancy/woman). Several sets criteria were used to define remission, damage. APOs included: foetal/neonatal death, placental...
Proliferative glomerulonephritis is a severe condition often leading to kidney failure. There significant lack of effective treatment for these disorders. Here, following the identification somatic PIK3CA gain-of-function mutation in podocytes patient, we demonstrate using multiple genetically engineered mouse models, single-cell RNA sequencing and spatial transcriptomics crucial role played by this pathway proliferative development promoting podocyte proliferation, dedifferentiation...
<h3>Background</h3> Data on the prognosis of non-infectious mixed cryoglobulinaemia vasculitis (CryoVas) in era hepatitis C virus screening are lacking. <h3>Methods</h3> The French multicentre and retrospective CryoVas survey included 242 patients with CryoVas. Causes death prognostic factors survival were assessed a score was determined to predict at 5 years. <h3>Results</h3> After median follow-up 35 months, 42 (17%) died. mainly serious infections (50%) flare (19%). One-, 2-, 5- 10-year...
Noninfectious mixed cryoglobulinemic GN (MCGN) has been poorly investigated. We analyzed presentation and outcome of 80 patients with biopsy-proven MCGN, which were identified in the retrospective French CryoVas survey. MCGN was related to primary Sjögren's syndrome 22.5% lymphoproliferative disorders 28.7% patients, defined as essential 48.8% patients. At presentation, hematuria, proteinuria ≥1 g/d, hypertension, renal failure observed 97.4%, 84.8%, 85.3%, 82.3% cases, respectively....
Significance Statement The clinical significance of arteritis the small kidney arteries has not been evaluated in detail antineutrophil cytoplasmic antibody–associated vasculitis (AAV). A large multicenter cohort 251 patients diagnosed with AAV and renal involvement, including 34 (13.5%) arteritis, found were older had a more severe inflammatory syndrome compared who did have arteritis. presence on biopsy was associated poorer prognosis, independent current risk stratification predictive...
Rituximab is used in the treatment of lymphoma and autoimmune diseases, for which late-onset neutropenia (LON) were reported. LON-related mechanisms remain unclear. To obtain insights into mechanisms, we assessed serum, peripheral blood bone marrow (BM) samples a patient with LON. Factors classically associated such as anti-neutrophil antibodies, T-LGL, soluble Fas Ligand not detectable. We then evaluated kinetics various cytokines involved B-cell granulocyte homeostasis. found that LON...
ABSTRACT Background Patients on maintenance haemodialysis (HD) have an increased risk of severe coronavirus disease 2019 (COVID-19) and a reduced response to vaccines. Data are needed identify immune correlates protection in this population. Methods Following COVID-19 outbreak among vaccinated patients HD unit, clinical data serological BNT162b2 vaccine were retrospectively recorded. Results Among 53 present the dialysis room, 14 infected by acute respiratory syndrome 2 (SARS-CoV-2) alpha...
X-linked Alport syndrome (XLAS) is an inherited kidney disease caused exclusively by pathogenic variants in the COL4A5 gene. In 10-20% of cases, DNA sequencing exons or flanking regions cannot identify molecular causes. Here, our objective was to use a transcriptomic approach causative events group 19 patients with XLAS without identified mutation gene panel sequencing. Bulk RNAseq and/or targeted using capture genes performed. Alternative splicing were compared those 15 controls developed...
Background. Post-allogeneic haematopoietic stem cell transplantation (HSCT) membranous nephropathy (MN), a rare complication of HSCT, remains an ill-defined entity. We describe the clinical and biological characteristics outcome five patients with post-HSCT MN, review previously reported cases discuss pathogenic aspects this nephropathy.
Background Tubulointerstitial fibrosis (fibrosis), a histologic feature associated with failing kidney allograft, is diagnosed using the invasive allograft biopsy. A noninvasive diagnostic test for may help improve outcome. Methods We obtained 114 urine specimens from renal recipients: 48 recipients in their biopsy results and 66 normal results. Levels of messenger RNAs (mRNAs) urinary cells were measured kinetic, quantitative polymerase chain reaction assays, levels related to diagnosis....