A5022866102- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Pneumocystis jirovecii pneumonia detection and treatment
- Transplantation: Methods and Outcomes
- Viral Infections and Immunology Research
- Eosinophilic Disorders and Syndromes
- Renal Transplantation Outcomes and Treatments
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Renal Diseases and Glomerulopathies
- Inflammatory Myopathies and Dermatomyositis
- Systemic Lupus Erythematosus Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vasculitis and related conditions
- Cardiac Structural Anomalies and Repair
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Sinusitis and nasal conditions
- Biosimilars and Bioanalytical Methods
- Peripheral Neuropathies and Disorders
- Organ and Tissue Transplantation Research
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Renal and Vascular Pathologies
Pitié-Salpêtrière Hospital
2015-2025
Sorbonne Université
2015-2025
Assistance Publique – Hôpitaux de Paris
2014-2025
Inserm
2017-2023
Université Paris Cité
2012-2018
Hôpital Charles-Nicolle
2017
University of Alberta
2017
Hôpital Européen Georges-Pompidou
2017
Hôpital Laennec
2017
Hôpital Necker-Enfants Malades
2017
Immune-checkpoint-inhibitor (ICI)-associated myotoxicity involves the heart (myocarditis) and skeletal muscles (myositis), which frequently occur concurrently are highly fatal. We report results of a strategy that included identification individuals with severe ICI myocarditis by also screening for managing concomitant respiratory muscle involvement mechanical ventilation, as well treatment CTLA4 fusion protein abatacept JAK inhibitor ruxolitinib. Forty cases definite were pathologic...
Rejection is one of the major causes late cardiac allograft failure and at present can only be diagnosed by invasive endomyocardial biopsies. We sought to determine whether microRNA profiling could serve as a non-invasive biomarker rejection.We included 113 heart transplant recipients from four referral French institutions (test cohort, n = 60, validation 53). In test we compared patients with acute biopsy-proven rejection (n 30) matched control without 30), assessing microRNAs expression in...
Antibody-mediated rejection (AMR) contributes to heart allograft loss. However, an important knowledge gap remains in terms of the pathophysiology AMR and how detection immune activity, injury degree, stage could be improved by intragraft gene expression profiling.We prospectively monitored 617 transplant recipients referred from 4 French centers (January 1, 2006-January 2011) for AMR. We compared patients with (n=55) a matched control group 55 without characterized all using histopathology...
Expanded clinical experience with patients taking antiangiogenic compounds has come increasing recognition of the renal adverse effects. Because histology is rarely sought in those patients, consequences are underestimated. Antiangiogenic-treated-cancer who had a biopsy for effects from 2006 to 2013, were included current study. Clinical features and histologic findings reviewed. Our cohort was 100 (58 women) biopsy-proven kidney disease using anti-vascular endothelial growth factor (VEGF)...
In heart transplantation, there is a lack of robust evidence the specific causes late allograft failure. We hypothesized that substantial fraction failing allografts may be associated with antibody-mediated injury and immune-mediated coronary arteriosclerosis. included all patients undergoing retransplantation for terminal failure in three referral centers. performed an integrative strategy phenotyping by assessing vascular tree including histopathology immunohistochemistry together...
Noninfectious mixed cryoglobulinemic GN (MCGN) has been poorly investigated. We analyzed presentation and outcome of 80 patients with biopsy-proven MCGN, which were identified in the retrospective French CryoVas survey. MCGN was related to primary Sjögren's syndrome 22.5% lymphoproliferative disorders 28.7% patients, defined as essential 48.8% patients. At presentation, hematuria, proteinuria ≥1 g/d, hypertension, renal failure observed 97.4%, 84.8%, 85.3%, 82.3% cases, respectively....
Abstract Background Fulminant myocarditis (FM) is a severe condition primarily triggered by viruses. Anti-RNA polymerase III autoantibodies (RNApol3) which are typically found in patients with systemic sclerosis, have been reported influenza-related FM. Our objective to provide additional insight into RNApol3-associated Methods We retrospectively included all admitted our institution between January 2013 and June 2023 acute positive serum RNApol3. compared their characteristics, etiologies,...
Data regarding the incidence and outcome of renal involvement in patients with inflammatory myopathies (IM) remain scarce. We assessed causes acute kidney injury (AKI) chronic disease (CKD) 150 dermatomyositis, polymyositis, antisynthetase syndrome followed 3 French referral centers. Renal occurred 35 (23.3%) patients: AKI 16 (10.7%), CKD 31 (20.7%) patients. The main cause was drug or myoglobinuria-induced tubular necrosis. Male sex, cardiovascular risk factors, cardiac involvement, initial...
Objective. To report the incidence, predictors, and outcome of rituximab (RTX)-associated autoimmune disease flare. Methods. We conducted a retrospective study in tertiary referral center from 2005 to 2015. Disease flare was defined as onset new organ involvement or worsening within 4 weeks following RTX. Results. Among 185 patients, we identified 7 flares (3.4%). All were due type II mixed cryoglobulinemia vasculitis. Vasculitis occurred after median time 8 days (range 2–16) RTX infusion...
Pemetrexed, a multitargeted antifolate cytotoxic agent, is currently used primarily in combination with cisplatin for metastatic non-small cell lung cancer and malignant mesothelioma. Acute renal toxicity of pemetrexed has been recently described polychemotherapy, which the individual responsibility each drug difficult to establish. Only one recent report documents involvement long-term exposed patients. We on case rapidly progressive nephropathy leading cessation platinum salts secondary...
Management of the increasing number sensitized heart transplant candidates has become a recurrent issue. Rather than using pretransplant desensitization therapies, we used posttransplant prophylactic strategy. Our aim was to describe outcomes in recipients with preformed donor-specific anti-HLA antibodies (pfDSA) managed this strategy.A protocol applied patients transplanted pfDSA, consisting perioperative management DSA (polyvalent immunoglobulins +/- plasmapheresis sessions, according...
to describe hepatitis C virus (HCV)-related systemic vasculitis in patients without detectable mixed cryoglobulinemia (MC) and compare them typical cases of HCV-MC vasculitis.twelve HCV RNA+ with histologically proven the absence MC (cases) were retrospectively compared 48 (controls). Each case was matched 4 controls for age sex.the main epidemiological virologic features similar between controls. No clinical difference found, except lower rates arthralgias (33% vs 71%; p = 0.02) purpura...
The association between membranous nephropathy (MN) and immunological disorder-related liver disease has not been extensively investigated, the specific features of this uncommon association, if any, remain to be determined. We retrospectively identified 10 patients with association. aimed describe clinical, biological, pathological characteristics these their therapeutic management. possible involvement phospholipase A2 receptor (PLA2R) in apparent secondary forms MN was assessed by...
Background: In heart transplantation, antibody-mediated rejection (AMR) is a major contributor to patient morbidity and mortality. Multiple routine endomyocardial biopsies (EMB) remain the gold standard detect AMR, but this invasive procedure suffers from many limitations. We aimed develop validate an AMR risk model improve individual stratification of AMR. Methods: Heart recipients 2 referral transplant centers, Cedars-Sinai (US) Pitié-Salpêtrière (France), were included 2012 2019. Database...
Abstract Background Fulminant myocarditis is a rare and severe disease whose definite etiological diagnoses rely on pathological examination. Albeit, myocardial biopsy can be associated with significant morbidity mortality, its therapeutic consequences are unclear. We conducted study to determine the diagnostic yield, safety of in patients fulminant clinically suspected unweanable from mechanical circulatory support (MCS). Methods Monocenter, retrospective, observational cohort 26-bed French...