A5044936234- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Nitric Oxide and Endothelin Effects
- Heart Failure Treatment and Management
- Hormonal Regulation and Hypertension
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Sulfur Compounds in Biology
- Receptor Mechanisms and Signaling
- Renal Diseases and Glomerulopathies
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Emergency and Acute Care Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Hepatitis C virus research
- Facial Nerve Paralysis Treatment and Research
- Orthopedic Surgery and Rehabilitation
- Neuropeptides and Animal Physiology
- Cytokine Signaling Pathways and Interactions
Paris Cardiovascular Research Center
2020-2024
Université Paris Cité
2020-2024
Inserm
2020-2024
Assistance Publique – Hôpitaux de Paris
2023-2024
University of Parma
2024
University of British Columbia
2021
Translational Research in Oncology
2019
Louisiana State University Health Sciences Center New Orleans
2017-2018
University of Alberta
2016
Tulane University
2015-2016
Abstract In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between donor-inherited lesions those acquired post-transplantation. However, many centers do not perform such since they invasive, costly may delay the transplant procedure. We aim generate a non-invasive virtual biopsy system using routinely collected donor parameters. Using 14,032 from 17 international centers, we develop system. 11 basic parameters predict four Banff lesions:...
Cardiac allograft vasculopathy (CAV) is a major contributor of heart transplant recipient mortality. Little known about the prototypes CAV trajectories at population level. We aimed to identify different evolutionary profiles and determine respective contribution immune nonimmune factors in development.Heart recipients were from 4 academic centers (Pitié-Salpêtrière Georges Pompidou Hospital, Paris, Katholieke Universiteit Leuven, Cedars-Sinai, Los Angeles; 2004-2016). Patients underwent...
Apheresis-based desensitization allows for successful transplantation across major immunological barriers. For donor-specific antibody (DSA)- and/or crossmatch-positive transplantation, however, it has been shown that even intense immunomodulation may not completely prevent antibody-mediated rejection (ABMR).In this study, we evaluated transplant outcomes in 101 DSA+ deceased donor kidney recipients (transplantation between 2009 and 2013; median follow-up: 24 months) who were subjected to...
Significance Statement Differential diagnosis of transplant glomerulopathy, a common lesion observed after kidney that is associated with poor prognosis, remains challenging because its morphologic pattern (double contour the glomerular basement membrane ) found in several disease processes. The authors used archetype analysis, probabilistic data-driven unsupervised statistical approach, to identify distinct groups patients (archetypes) this condition. By applying approach large,...
BackgroundKidney allograft failure is a common cause of end-stage renal disease. We aimed to develop dynamic artificial intelligence approach enhance risk stratification for kidney transplant recipients by generating continuously refined predictions survival using updates clinical data.MethodsIn this observational study, we used data from adult transplants 18 academic centres in Europe, the USA, and South America, cohort patients six randomised controlled trials. The development comprised...
There is a paucity of data about the mechanisms by which sacubitril/valsartan (also known as LCZ696) improves outcomes in patients with heart failure. Specifically, effects on vascular function and NO bioavailability have not been investigated. We hypothesized that therapy increases circulating levels setting failure.Male spontaneously hypertensive rats underwent myocardial ischemia/reperfusion surgery to induce failure were followed for up 12 weeks serial echocardiography. Rats received (68...
The heterogeneous clinical presentation of graft microvascular inflammation poses a major challenge to successful kidney transplantation. effect on allograft outcomes is unclear.
Hydrogen sulfide (H2S) is an endogenous gaseous molecule formed from L-cysteine in vascular tissue. In the present study, cardiovascular responses to H2S donors Na2S and NaHS were investigated anesthetized rat. The intravenous injections of 0.03-0.5 mg/kg produced dose-related decreases systemic arterial pressure heart rate, at higher doses cardiac output, pulmonary pressure, resistance. infusion studies show that resistance are well-maintained, reversible. Decreases rate not blocked by...
Hydrogen sulfide (H2S) is a biologically active endogenous gasotransmitter formed in penile tissue that has been shown to relax isolated cavernosal smooth muscle. In the present study, erectile responses H2S donors sodium (Na2S) and hydrosulfide (NaHS) were investigated anesthetized rat. Intracavernosal injections of Na2S doses 0.03-1 mg/kg increased intracavernosal pressure transiently decreased mean arterial dose-dependent manner. Blood rapid onset short duration. Responses NaHS similar at...
Background: In heart transplantation, antibody-mediated rejection (AMR) is a major contributor to patient morbidity and mortality. Multiple routine endomyocardial biopsies (EMB) remain the gold standard detect AMR, but this invasive procedure suffers from many limitations. We aimed develop validate an AMR risk model improve individual stratification of AMR. Methods: Heart recipients 2 referral transplant centers, Cedars-Sinai (US) Pitié-Salpêtrière (France), were included 2012 2019. Database...
Pulmonary hypertension is a rare disorder that, without treatment, progressive and fatal within 3-4 years. Current treatment involves diverse group of drugs that target the pulmonary vascular bed. In addition, strategies increase nitric oxide (NO) formation have beneficial effect in rodents patients. Nebivolol, selective β1 adrenergic receptor-blocking agent reported to NO production stimulate β3 receptors, has vasodilator properties suggesting it may be hypertension. The present study was...
The kallikrein-kinin system is expressed in the corpus cavernosa, and bradykinin (BK) relaxes isolated corpora cavernosal strips. However, erectile responses to BK rat have not been investigated vivo. In present study, intracorporal (ic) injections of were anesthetized rat. BK, doses 1–100 μg/kg ic, produced dose-related increases intracavernosal pressure (ICP) deceases mean arterial (MAP). When decreases MAP prevented by intravenous angiotensin II (Ang II), ICP, response enhanced. Increases...
Abstract Background and Aims The Banff histological classification is the gold standard for allograft rejection diagnostics but has become considerably more complex over past three decades, leading to misclassifications. We aimed develop an automated system demonstrate its ability improve diagnoses. Method built a consortium consisting of pathologists, physicians, developers translate all rules until latest version published in 2019 into algorithm, further embedded application which...