A5045640920- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Neurological Complications and Syndromes
- Atherosclerosis and Cardiovascular Diseases
- Pharmacological Effects and Toxicity Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Pregnancy and Medication Impact
- Cytomegalovirus and herpesvirus research
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Fungal Infections and Studies
- Liver Disease and Transplantation
- Renal Diseases and Glomerulopathies
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Complement system in diseases
- Polyomavirus and related diseases
- Parvovirus B19 Infection Studies
- Mast cells and histamine
- Vasculitis and related conditions
- Full-Duplex Wireless Communications
- Chronic Kidney Disease and Diabetes
Assistance Publique – Hôpitaux de Paris
2017-2025
Hôpital Saint-Louis
2024-2025
Paris Cardiovascular Research Center
2021-2024
Université Paris Cité
2017-2024
Inserm
2019-2024
Sorbonne Paris Cité
2017-2024
Hôpital Necker-Enfants Malades
2019-2023
Translational Research in Oncology
2019-2022
Délégation Paris 5
2022
Délégation Paris 7
2017-2019
Abstract Objective To develop and validate an integrative system to predict long term kidney allograft failure. Design International cohort study. Setting Three cohorts including transplant recipients from 10 academic medical centres Europe the United States. Participants Derivation cohort: 4000 consecutive prospectively recruited in four French between 2005 2014. Validation cohorts: 2129 three 1428 North America, 2002 Additional validation randomised controlled trials ( NCT01079143 ,...
Abstract In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between donor-inherited lesions those acquired post-transplantation. However, many centers do not perform such since they invasive, costly may delay the transplant procedure. We aim generate a non-invasive virtual biopsy system using routinely collected donor parameters. Using 14,032 from 17 international centers, we develop system. 11 basic parameters predict four Banff lesions:...
Poor responses to mRNA COVID-19 vaccine have been reported after 2 injections in kidney transplant recipients (KTRs) treated with belatacept. We analyzed the humoral response belatacept-treated KTRs without a history of SARS-CoV-2 infection who received three BNT162b2-mRNA vaccine. also investigated immunogenicity prior and characterized symptomatic infections KTRs. Among 62 (36 [58%] males), median age (63.5 years IQR [51–72]), history, only four patients (6.4%) developed anti-SARS-CoV-2...
Abstract Objective To compare the performance of a newly developed race-free kidney recipient specific glomerular filtration rate (GFR) equation with three current main equations for measuring GFR in transplant recipients. Design Development and validation study Setting 17 cohorts Europe, United States, Australia (14 centres, clinical trials). Participants 15 489 adults (3622 development cohort (Necker, Saint Louis, Toulouse hospitals, France), 11 867 multiple external cohorts) who received...
Conversion to a belatacept-based immunosuppression is currently used as calcineurin inhibitor (CNI) avoidance strategy when the CNI-based standard-of-care not tolerated after kidney transplantation. However, there lack of evidence on long-term benefit and safety conversion belatacept.
Background Many kidneys donated for transplant in the United States are discarded because of abnormal histology. Whether histology adds incremental value beyond usual donor attributes assessing allograft quality is unknown. Methods This population-based study included patients who received a deceased kidney that had been biopsied before implantation according to prespecified protocol France and Belgium, where preimplantation biopsy findings generally not used decision making allocation...
BackgroundKidney allograft failure is a common cause of end-stage renal disease. We aimed to develop dynamic artificial intelligence approach enhance risk stratification for kidney transplant recipients by generating continuously refined predictions survival using updates clinical data.MethodsIn this observational study, we used data from adult transplants 18 academic centres in Europe, the USA, and South America, cohort patients six randomised controlled trials. The development comprised...
Over the past decades, an international group of experts iteratively developed a consensus classification kidney transplant rejection phenotypes, known as Banff classification. Data-driven clustering histologic data could simplify complex and discretionary rules classification, while improving association with graft failure.The consisted training set 3510 kidney-transplant biopsies from observational cohort 936 recipients. Independent validation results was performed on external 3835 1989...
Objectives Development of pharmaceutical agents in transplantation is currently limited by long waits for hard endpoints. We applied a validated integrative risk-prognostication system Box (iBox) as surrogate endpoint to the TRANSFORM Study, large randomised controlled trial, project individual patient long-term kidney allograft survival from 1 year 11 years after randomisation. Design Post-hoc analysis open-label trial. Setting Multicentre study including 186 centres 42 countries worldwide....
New immunosuppressive therapies that improve long-term graft survival are needed in kidney transplant. Critical Path Institute's Transplant Therapeutics Consortium received a qualification opinion for the iBOX Scoring System as novel secondary efficacy endpoint transplant clinical trials through European Medicines Agency's of methodologies drug development. This is first qualified any indication and now available use trials. Although current failure has typically shown noninferiority...
The heterogeneous clinical presentation of graft microvascular inflammation poses a major challenge to successful kidney transplantation. effect on allograft outcomes is unclear.
No validated system currently exists to realistically characterize the chronic pathology of kidney transplants that represents dynamic disease process and spectrum severity. We sought develop validate a tool describe chronicity severity renal allograft integrate it with evaluation activity.The training cohort included 3549 transplant biopsies from an observational 937 recipients. reweighted histologic lesions according their time-dependent association graft failure, performed consensus...
Abstract Background Clinical decisions are mainly driven by the ability of physicians to apply risk stratification patients. However, this task is difficult as it requires complex integration numerous parameters and impacted patient heterogeneity. We sought evaluate transplant predict long-term allograft failure compare them a validated artificial intelligence (AI) prediction algorithm. Methods randomly selected 400 kidney recipients from qualified dataset 4000 For each patient, 44 features...
BK polyomavirus (BKPyV) infection remains a major concern after kidney transplantation, increasing the risk of graft loss in absence specific antiviral agent now available. Here, we investigated impact HLA diversity on control posttransplant BKPyV replication. High evolutionary divergence (HED) at DQ locus donor was an independent predictor BKPyV-free outcome. More generally, highlighted protective effect highly divergent pairs HLA-DQ heterodimers corresponding to heterozygous...
Cardiovascular disease (CVD) is the main cause of death in systemic lupus erythematous (SLE) patients. The Framingham score underestimates risk for CVD this population. Our study aimed to determine whether serum high-sensitivity cardiac troponin T (HS-cTnT) might help identify SLE patients at CVD.The presence carotid plaques was prospectively assessed by ultrasound 63 consecutive asymptomatic and 18 controls. Serum HS-cTnT concentration measured using electrochemiluminescence method. Factors...
Background. Oral anticoagulation therapy is frequently prescribed to kidney transplant recipients (KTRs) for prevention and treatment of thrombotic events. Over the past 10 y, direct oral anticoagulants (DOACs) have shown similar efficacy with a safety profile equal or superior that vitamin K antagonist (VKAs) in general population. However, little data are available on transplantation. Methods. We investigated (thrombotic events) (hemorrhagic other adverse events graft outcomes) DOACs...
Key Points Prediction models are becoming increasingly relevant in precision medicine. These should be highly performant and not negatively affected by competing risk events. We thus aimed to carefully assess the effect of risks allograft failure prediction. Background Prognostic clinical trials as potential surrogate end points for patient management decision support tools. However, on model performance remains poorly investigated. noncompeting context kidney transplantation, where death...
Objective: This study aimed to determine whether sCD163, a soluble macrophage marker up-regulated in numerous inflammatory disorders, is predictive of accelerated atherosclerosis associated with systemic lupus erythematosus (SLE).Methods: Carotid ultrasound was prospectively performed, at baseline and during follow-up, 63 consecutive SLE patients asymptomatic for cardiovascular disease (CVD) 18 volunteer health workers. Serum sCD163 level determined using enzyme-linked immunosorbent assay....
Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well features radiological characteristics, have not yet been considered on a large scale context kidney transplantation (KT). We performed nationwide retrospective study adult patients diagnosed with cryptococcosis after KT between 2002 2020 across 30 centers France. sought to describe overall graft...