A5042406517- Renal and Vascular Pathologies
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Medical Imaging and Pathology Studies
- Parathyroid Disorders and Treatments
- Transplantation: Methods and Outcomes
- Artificial Intelligence in Healthcare and Education
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Renal function and acid-base balance
- Patient Satisfaction in Healthcare
- Acute Kidney Injury Research
- Liver Disease and Transplantation
- Health Sciences Research and Education
- Palliative Care and End-of-Life Issues
- Biomedical and Engineering Education
- Diversity and Career in Medicine
- Healthcare cost, quality, practices
- COVID-19 and healthcare impacts
- Dialysis and Renal Disease Management
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Chronic Kidney Disease and Diabetes
Ikazia Ziekenhuis
2024
University Medical Center Groningen
2017-2023
University of Groningen
2017-2023
Maasstad Ziekenhuis
2022
Christian Health Association of Malawi
2019-2020
Fundación Juan March
2020
Leiden University Medical Center
2018-2019
Dialyse Centrum Groningen
2019
Leiden University
2017-2018
At the beginning of artificial intelligence (AI)/machine learning (ML) era, expectations are high, and experts foresee that AI/ML shows potential for diagnosing, managing treating a wide variety medical conditions. However, obstacles implementation in daily clinical practice numerous, especially regarding regulation these technologies. Therefore, we provide an insight into currently available AI/ML-based devices algorithms have been approved by US Food & Drugs Administration (FDA). We aimed...
Abstract Objective To compare the performance of a newly developed race-free kidney recipient specific glomerular filtration rate (GFR) equation with three current main equations for measuring GFR in transplant recipients. Design Development and validation study Setting 17 cohorts Europe, United States, Australia (14 centres, clinical trials). Participants 15 489 adults (3622 development cohort (Necker, Saint Louis, Toulouse hospitals, France), 11 867 multiple external cohorts) who received...
Amiodarone is used for the maintenance of sinus rhythm in patients with arrhythmias, but thyroid dysfunction (amiodarone-induced thyrotoxicosis (AIT) or amiodarone-induced hypothyroidism (AIH)) a common adverse effect. As onset AIT and AIH may be unpredictable, value long-term regular monitoring amiodarone treated still uncertain.We retrospectively documented frequency at which overt was preceded by subclinical dysfunction.We included 303 between 1984 2007. defined as lowered TSH level an...
Background. Chronic kidney disease mineral and bone disorders (CKD-MBD) vascular calcification are often seen in transplantation recipients (KTR). This study focused on the bone–vascular axis hypothesis, pathophysiological mechanisms driving both loss calcification, supported by an association between lower density (BMD) higher risk of calcification. Methods. KTR referred for a dual-energy X-ray absorptiometry procedure within 6 mo after were included cross-sectional (2004–2014). Areal BMD...
Aortic calcification is associated with an increased risk for cardiovascular events in renal transplant recipients. This study focused on the association of abdominal aortic (AAC) and assessed using a dual-energy X-ray absorptiometry (DXA) scoring methodology AAC.From 2008 to 2014, recipients referred DXA procedure within 6 months after transplantation were included retrospective, single-centre study. The primary endpoint was occurrence events, defined as myocardial infarction,...
As vascular calcification is common in kidney transplant candidates, aorto-iliac vessel imaging performed for surgical planning. The aim of the present study was to investigate whether a novel non-contrast enhanced computed tomography-based quantification technique can be used cardiovascular risk stratification prior transplantation. In this dual-center cohort study, we measured calcium score (CaScore) 547 patients within three years transplantation (2005-2018). During median (interquartile...
Background Artificial intelligence (AI)– and machine learning (ML)–based medical devices algorithms are rapidly changing the field. To provide an insight into trends in AI ML health care, we conducted international patent analysis. Objective It is pivotal to obtain a clear overview on upcoming MLtrends care regulators with better position foresee what technologies they will have create regulations for, which not yet available market. Therefore, this study, insights forecasts by conducting...
Introduction This study focused on the value of quantitatively analyzed and qualitatively graded renal scintigraphy in relation to expected duration delayed graft function after kidney transplantation. A more reliable prediction may result a tailored patient-specific treatment regimen post-transplantation. Methods From 2000 2014, patients with early transplant dysfunction Tc-99m MAG3 scintigraphy, within 3 days post-transplantation, were included dual center retrospective study....
Abstract Purpose 2-deoxy-2-[ 18 F]fluoro- d -glucose ([ F]FDG) uptake is a marker of metabolic activity and therefore used to measure the inflammatory state several tissues. This radionuclide transported through cell membrane via glucose transport proteins (GLUTs). The aim this study investigate whether insulin resistance (IR) or inflammation plays role in [ F]FDG adipose tissue (AT). Procedures consisted an vivo clinical part ex mechanistic part. In part, abdominal visceral AT (VAT)...
While the association of vascular calcification with inferior patient outcomes in kidney transplant recipients is well-established, graft has received less attention. With this dual-centre cohort study, we aimed to determine clinical impact recipient pre-transplant aorto-iliac calcification, measured on non-contrast enhanced computed tomography (CT)-imaging within three years prior transplantation (2005–2018). We included 547 patients (61.4% male, age 60 (interquartile range 51–68) years), a...
With a later onset of diabetes complications and thus increasing age transplant candidates, many centers have extended upper limits for pancreas transplantation. This study investigates the effect recipient donor on outcomes after transplantation.We retrospectively analyzed 565 transplants performed at two Eurotransplant centers. The cohort was split 50 40 years, respectively. Median in old patients (≥50 years; 27.2%) 54 years young (<50 years). Compared to recipients, recipients had an...
The COVID-19 pandemic has vast global consequences. Yet, effective mitigation strategies and economic medical outfall differ extensively across the globe. It is currently unclear how well researchers from all continents are represented in unsolicited solicited publications. A literature review was performed SCOPUS on oriented publications four most impactful journals. These included British Medical Journal, Journal of American Association, New England Medicine Lancet. We identified 809...
Duration of delayed graft function (DGF) and length hospital stay (LOS) are outcomes interest in an era that warrants increased efficacy transplant care whereas renal allografts originate increasingly from marginal donors. While earlier studies investigate the predictive capability a single scintigraphy, this study focuses on value for both DGF duration LOS consecutively performed scintigraphies. From 2011 to 2014, recipients referred Tc-99m MAG3 scintigraphy were included single-center...
Doppler ultrasound, including intrarenal resistance index (RI) measurement, is a widely used modality to assess kidney transplantation (KTx) vascularization. The aim of this study gain insight in the associations between early postoperative RI measurements and cardiovascular events (CVEs), all-cause mortality, death-censored graft survival.From 2015 2017, prospective cohort was conducted patients which measurement performed immediately after KTx. calculated as (peak systolic...