Jean Villard
A5091324826- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- Cancer Immunotherapy and Biomarkers
- Cytomegalovirus and herpesvirus research
- Antifungal resistance and susceptibility
- Immunodeficiency and Autoimmune Disorders
- CAR-T cell therapy research
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Renal Diseases and Glomerulopathies
- Pneumocystis jirovecii pneumonia detection and treatment
- Pluripotent Stem Cells Research
- Transplantation: Methods and Outcomes
- Cancer Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Fungal Infections and Studies
- Reproductive System and Pregnancy
- Complement system in diseases
- Plant Pathogens and Fungal Diseases
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Fungal Biology and Applications
Swiss HIV Cohort Study
2023-2025
Université Paris Cité
2001-2024
University Hospital of Geneva
2015-2024
University of Geneva
2012-2024
Geneva College
2004-2024
University Hospital of Zurich
2022-2024
Inserm
2024
Assistance Publique – Hôpitaux de Paris
2024
University of Zurich
2024
Hôpital Beau-Séjour
2023
Abstract Background The burden and timeline of posttransplant infections are not comprehensively documented in the current era immunosuppression prophylaxis. Methods In this prospective study nested within Swiss Transplant Cohort Study (STCS), all clinically relevant were identified by transplant–infectious diseases physicians persons receiving solid organ transplant (SOT) between May 2008 December 2014 with ≥12 months follow-up. Results Among 3541 SOT recipients, 2761 (1612 kidney, 577...
By virtue of its control over major histocompatibility complex class II (MHC-II) gene expression, CIITA represents a key molecule in the regulation adaptive immune responses. It was first identified as factor that is defective MHC-II deficiency, hereditary disease characterized by absence expression. highly regulated transactivator governs all spatial, temporal, and quantitative aspects has been proposed to act non-DNA-binding transcriptional coactivator, but evidence it actually functions...
Abstract Natural killer (NK) cells play a crucial role in the immune response to micro-organisms and tumours. Recent evidence suggests that NK also regulate adaptive T-cell it might be possible exploit this ability eliminate autoreactive T autoimmune disease alloreactive transplantation. Mature consist of highly diverse population expresses different receptors facilitate recognition diseased possibly pathogens themselves. Ex vivo culture with cytokines such as IL-2 IL-15 is an approach...
In solid organ transplanted patients, annual influenza immunization is strongly recommended because of morbidity and mortality infections. 2009, the rapid spread a novel H1N1 A virus led to accelerated development pandemic vaccines. Switzerland, recipients received one dose seasonal two doses AS03-adjuvanted This situation provided unique opportunity analyze influence adjuvanted vaccines on production de novo anti-HLA antibodies. We prospectively followed independent cohorts including 92 59...
Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden vaccine-preventable infections (VPIs) among SOT recipients remains unclear.To assess incidence rate VPIs to evaluate whether at increased risk for specific compared with general population.This nationwide cohort study used data from Swiss Transplant Cohort Study on individuals who underwent May 2008 June 2019...
This study evaluated the prognostic impact of pretransplant donor-specific anti-human leukocyte antigen antibodies (DSA) detected by single-antigen beads and compared three generations crossmatch (XM) tests in kidney transplantation.Thirty-seven T-cell complement-dependent cytotoxicity (CXM) negative living donor recipients with a retrospectively positive antihuman antibody screening assay were included. A bead test, flow cytometry XM, Luminex XM (LXM) performed, results correlated...
Renal thrombotic microangiopathy (TMA) is a severe complication of systemic lupus erythematosus (SLE), which associated with the presence antiphospholipid (aPL) antibodies. In its most fulminant form, TMA leads to rapid and irreversible end-stage renal failure. Eculizumab, an anti-C5 monoclonal antibody, novel therapy choice for patients paroxysmal nocturnal hemoglobinuria (PNH) atypical hemolytic uremic syndrome. Here, we report case 27-year-old woman, known SLE disease due TMA. Both aPL...
The main aim of this study was to evaluate the significance HLA-DPB1 expression in acute graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT) from HLA-A, -B, -C, -DRB1, -DQB1-matched and -mismatched unrelated donors.
Forty-four thyroid autonomously hyperfunctioning adenomas were analyzed to assess the frequency of mutations occurring in TSH receptor (TSHR). PCR-amplified fragments encompassing entire exon 10 TSHR gene obtained from genomic DNA extracted tumors and their adjacent normal tissues examined by direct nucleotide sequencing. Point found 9 44 (20%). One mutation occurred codon 619 (Asp Gly), four 623 (three Ala Ser, one Val substitution), two 632 (both Thr Ile), 633 Tyr or His). All alterations...
Results of islet Langerhans transplantation have markedly improved in recent years, but most patients still lose insulin independence the long-term. We report herein longest (over 11 years) case after allogeneic transplantation. The subject had a 27-year history type 1 diabetes and received single islet-after-kidney graft 8800 equivalents (IEQ)/kg, pooled from 2 donors. Insulin was discontinued by 3 months posttransplant patient has remained off ever since. Yearly follow-up studies revealed...
There are limited contemporary data on the epidemiology and outcomes of bacteremia in solid organ transplant recipients (SOTr).Using Swiss Transplant Cohort Study registry from 2008 to 2019, we performed a retrospective nested multicenter cohort study describe SOTr during first year post-transplant.Of 4383 patients, 415 (9.5%) with 557 cases due 627 pathogens were identified. One-year incidence was 9.5%, 12.8%, 11.4%, 9.8%, 8.3%, 5.9% for all, heart, liver, lung, kidney, kidney-pancreas...
Living donor (LD) kidney transplantation in the setting of ABO blood group incompatibility (ABOi) has been previously reported to be associated with increased risk for antibody-mediated rejection (ABMR). It is however unclear if presence pre-transplant specific antibodies (DSA) works as an additive factor ABOi and DSA positive transplants have a significantly worse long-term outcome compared compatible (ABOc) transplants.
The heterogeneous clinical presentation of graft microvascular inflammation poses a major challenge to successful kidney transplantation. effect on allograft outcomes is unclear.
Importance Surgical site infections (SSIs) are one of the most common health care–associated infections. can have harmful effects in liver transplant (LT) recipients. Objective To assess incidence SSI after LT and identify risk factors associated with SSIs whether death graft loss. Design, Setting, Participants A multicenter cohort study encompassing data on performed at all Swiss centers between May 1, 2008, September 30, 2020, was conducted. Data analyses were 2023. Exposure Liver...
<p>Representativeness of Study Participants</p>