A5008926648- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- Influenza Virus Research Studies
- Respiratory viral infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral gastroenteritis research and epidemiology
- Polyomavirus and related diseases
- Antibiotic Use and Resistance
- SARS-CoV-2 and COVID-19 Research
- Adenosine and Purinergic Signaling
- Histone Deacetylase Inhibitors Research
- Hepatitis B Virus Studies
- Antifungal resistance and susceptibility
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Bartonella species infections research
- Autoimmune and Inflammatory Disorders
- Salmonella and Campylobacter epidemiology
- Healthcare Systems and Technology
- vaccines and immunoinformatics approaches
- Gut microbiota and health
- Healthcare cost, quality, practices
- Bacterial Infections and Vaccines
- Peptidase Inhibition and Analysis
- Clostridium difficile and Clostridium perfringens research
Ente Ospedaliero Cantonale
2025
Ospedale Regionale di Locarno
2024
University of Lausanne
2010-2023
University Hospital of Lausanne
2010-2016
Immunocompromised patients may be at increased risk for complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, comprehensive data SARS-CoV-2 infection in solid organ transplant (SOT) recipients are still lacking. We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe epidemiology, clinical presentation, treatment and outcomes first microbiologically documented among SOT recipients....
Abstract Short chain fatty acids (SCFAs) produced by intestinal microbes mediate anti-inflammatory effects, but whether they impact on antimicrobial host defenses remains largely unknown. This is of particular concern in light the attractiveness developing SCFA-mediated therapies and considering that SCFAs work as inhibitors histone deacetylases which are known to interfere with defenses. Here we show propionate, one main SCFAs, dampens response innate immune cells microbial stimulation,...
Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden vaccine-preventable infections (VPIs) among SOT recipients remains unclear.To assess incidence rate VPIs to evaluate whether at increased risk for specific compared with general population.This nationwide cohort study used data from Swiss Transplant Cohort Study on individuals who underwent May 2008 June 2019...
Abstract Background The use of assays detecting cytomegalovirus (CMV)–specific T cell–mediated immunity may individualize the duration antiviral prophylaxis after transplantation. Methods In this randomized trial, kidney and liver transplant recipients from 6 centers in Switzerland were enrolled if they CMV-seronegative with seropositive donors or CMV-seropositive receiving antithymocyte globulins. Patients to a based on immune monitoring (intervention) fixed (control). control group planned...
Histone deacetylases (HDACs) control gene expression by deacetylating histones and nonhistone proteins. HDAC inhibitors (HDACi) are powerful anticancer drugs that exert anti-inflammatory immunomodulatory activities. We recently reported a proof-of-concept study demonstrating HDACi increase susceptibility to bacterial infections in vivo. Yet, still little is known about the effects of on antimicrobial innate immune defenses. Here we show belonging different chemical classes inhibit at...
Sirtuin 2 (SIRT2) is one of the seven members family NAD+-dependent histone deacetylases. Sirtuins target histones and non-histone proteins according to their subcellular localization, influencing various biological processes. SIRT2 resides mainly in cytoplasm regulates cytoskeleton dynamics, cell cycle metabolic pathways. As such, has been implicated pathogenesis neurodegenerative, metabolic, oncologic chronic inflammatory disorders. This motivated development SIRT2-directed therapies for...
Abstract Background One of the main objective Antimicrobial Stewardship programmes (ASp) is optimization antibiotic use, reducing use broad spectrum antibiotics when unnecessary. In this context, close monitoring carbapenem consumption mandatory. Methods The CASAS Project started in January 2024 4 public Hospitals (for a total approximately 1000 beds) Southern Switzerland, region with low prevalence multi-drug-resistant bacteria (MDR) and treatments (CAR-T). An electronic alert was sent to...
Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation (SOT). Most PTLD cases are associated with Epstein-Barr virus (EBV) infection. The role antiviral prophylaxis or rituximab therapy for prevention in SOT recipients controversial. In nationwide cohort, we assessed the incidence, presentation, and outcome histologically proven PTLD. We included 4765 patients follow-up duration 23 807 person-years (py). Fifty-seven were identified; 39...
To describe the epidemiology and clinical presentation of central nervous system (CNS) infections in solid organ transplant (SOT) recipients current era transplantation.Patients from Swiss Transplant Cohort Study (STCS) transplanted between 2008 2018 were included with a median follow-up 3.8 years. Epidemiological, microbiological, data extracted STCS database patients' medical records. We calculated incidence rates 90-day survival CNS infection.Among 4762 patients, 42 episodes infection 41...
Solid organ transplant (SOT) recipients are exposed to respiratory viral infection (RVI) during seasonal epidemics; however, the associated burden of disease has not been fully characterized. We describe epidemiology and outcomes RVI in a cohort enrolling 3294 consecutive patients undergoing SOT from May 2008 December 2015 Switzerland. Patient allograft outcomes, diagnosed routine clinical practice were prospectively collected. Median follow-up was 3.4 years (interquartile range 1.61-5.56)....
Abstract Background The immunogenicity of the standard influenza vaccine is reduced in solid-organ transplant (SOT) recipients, so new vaccination strategies are needed this population. Methods Adult SOT recipients from 9 clinics Switzerland and Spain were enrolled if they >3 months after transplantation. Patients randomized (1:1:1) to a MF59-adjuvanted or high-dose (intervention), (control), with stratification by organ time transplant. primary outcome was response rate, defined as...
Cytomegalovirus (CMV) disease has been associated with the development of chronic lung allograft dysfunction (CLAD) after transplantation. However, relevance CMV replication occurring discontinuation antiviral prophylaxis on CLAD not fully established. Patients who underwent transplantation during 2004-2014 were included. All patients received for 3-6 months, followed by monitoring first year post-transplantation (preemptive therapy). Risk factors assessed Cox models. A linear regression...
Background. ABO-incompatible (ABOi) kidney transplantation (KT) expands the donor pool and may help to overcome organ shortage. Nonetheless, concerns about infectious complications associated with ABOi-KT have been raised. Methods. In a nationwide cohort (Swiss Transplant Cohort Study), we compared risk for among ABOi ABO-compatible (ABOc) renal transplant recipients. Infections needed fulfill rigorous, prespecified criteria be classified as clinically relevant. Unadjusted adjusted competing...
Food-safety measures are recommended in solid organ transplant (SOT) recipients. However, the actual adherence of patients a real-life setting and impact on incidence foodborne infections remain largely unexplored. We performed survey among SOT recipients followed at our institution, aiming to evaluate their food-safety behavior. assessed microbiologically proven by chart review. One hundred ninety-seven (kidney = 117, lung 35, liver 29, heart 16) participated survey. Overall, 17.7%...
OBJECTIVES To investigate differences in chest computed tomography (CT) and radiographs (CXRs) of Pneumocystis jirovecii pneumonia (PJP) between renal transplant recipients (RTRs) human immunodeficiency virus (HIV)-positive patients. METHODS From 2005 to 2012, 84 patients with PJP (RTR n = 24; HIV 60) were included this retrospective multicentre study. Written informed consent was obtained. CT scans CXRs recorded within 2 weeks after the onset symptoms. diagnosis confirmed either by...
Food-safety measures are recommended to solid organ transplant (SOT) recipients. However, the burden of foodborne infections in SOT recipients has not been established. We describe epidemiology and outcomes bacterial a nationwide cohort including 4405 Switzerland between 2008 2018. Participants were prospectively followed for median 4.2 years with systematic collection data on infections, patient graft-related outcomes. identified 151 episodes microbiologically confirmed occurring 1.6 (IQR...
Aspergillus is a ubiquitary mold, with whom the human has often contact. Normally not pathogen for immunocompetent subject, but it can be source of infections in immunocompromised patient or persons structural pneumological pathologies. In other subjects elicit allergic reactions immunological response. These different pathologies are various and difficult to diagnose. We propose here view these
Background: In solid-organ transplant (SOT) recipients, influenza is associated with significant morbidity and mortality, while the immunogenicity of standard vaccine reduced. New vaccination strategies are needed. Methods: this observer participant masked randomised clinical trial, adult SOT recipients from nine clinics in Switzerland Spain were enrolled if they at least three months after transplantation. Patients (1:1:1) using an interactive web-based response system stratification by...