A5085553543- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Medical Practices and Rehabilitation
- Cardiovascular Function and Risk Factors
- Viral Infections and Immunology Research
- Cardiovascular and exercise physiology
- Cardiac Arrhythmias and Treatments
- Healthcare Systems and Practices
- Cardiac and Coronary Surgery Techniques
- Cardiomyopathy and Myosin Studies
- Eosinophilic Disorders and Syndromes
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Adipose Tissue and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac Valve Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Xenotransplantation and immune response
- Acute Myocardial Infarction Research
Hôpital Riviera-Chablais
2023-2025
University Hospital of Lausanne
2015-2023
University of Lausanne
2016-2022
Hôpital Orthopédique de la Suisse Romande
2017-2019
University Hospital of Basel
2015
Abstract Aims Clinical studies suggest beneficial effects of renin–angiotensin system blockade for prevention left ventricular (LV) dysfunction after chemotherapy. However, the efficacy this strategy as primary has been poorly studied. This study aimed at identifying pathophysiological mechanisms by which mineralocorticoid receptor antagonism (MRA) or angiotensin converting enzyme inhibition (ACEi) provide protection against doxorubicin-induced cardiotoxicity (DIC) in mouse models acute and...
Abstract Background Elevated red blood cell distribution width (RDW) is a valid predictor of outcome in acute heart failure (AHF). It unknown whether elevated RDW remains predictive AHF patients with either preserved left ventricular ejection fraction (LVEF) ≥50% or reduced LVEF (<50%). Methods and results Prospective local registry including 402 consecutive hospitalized without coronary syndrome need intensive care. The primary was all‐cause mortality (ACM) at 1 year after admission....
New-onset atrial fibrillation is frequently encountered in internal medicine or after surgery. The European Society of Cardiology 2024 guidelines may appear too detailed even complex for the non-specialist looking quick answers on topic. aim this article to answer 10 questions about initial management disease a synthetic and practical way according most recent guidelines.
A 22-year-old male with a typical history of pauci-symptomatic COVID-19 3 weeks earlier, confirmed by positive serology for SARS-CoV-2 (IgG), was admitted to the intensive care unit because severe myocarditis refractory cardiogenic shock that required extracorporeal life support. Due clinical presentation suggestive Kawasaki-like disease coronary aneurysm and systemic inflammation, intravenous immunoglobulins were administered in combination tocilizumab. The initial course favourable these...
Food-safety measures are recommended in solid organ transplant (SOT) recipients. However, the actual adherence of patients a real-life setting and impact on incidence foodborne infections remain largely unexplored. We performed survey among SOT recipients followed at our institution, aiming to evaluate their food-safety behavior. assessed microbiologically proven by chart review. One hundred ninety-seven (kidney = 117, lung 35, liver 29, heart 16) participated survey. Overall, 17.7%...
Abstract Aims Mild or moderate aortic regurgitation (AR) has only little effect on cardiovascular outcome in people with normal left ventricular ejection fraction (EF); therefore, it is not perceived as a major clinical problem. This study investigates whether mild AR associated increased short‐term mortality patients hospitalized for treatment of acute heart failure (AHF) and impacts differently AHF reduced EF (AHFrEF), mid‐range (AHFmrEF), preserved (AHFpEF). Methods results mono‐centric...
Abstract Antibody‐mediated rejection (AMR) is a major barrier preventing successful discordant organ xenotransplantation, but it also occurs in allotransplantation due to anti‐HLA antibodies. Symptomatic acute AMR rare after heart allograft carries high risk of mortality, especially >1 year transplant. As complement activation may play role mediating tissue injury AMR, drugs blocking the terminal cascade like eculizumab be useful, particularly since “standards care” plasmapheresis are not...
Scedosporium apiospermum associated endocarditis is extremely rare. We report a case of disseminated S. infection with an invasive right atrial mass in 52-year-old male, 11 months after heart transplantation, referred to our institution for endogenous endophthalmitis one-month history diffuse myalgias and fatigue. The patient had been supported two times extracorporeal membrane oxygenation (ECMO) during the first three postoperative months. echocardiography on admission revealed atrium...
Abstract Background The prognostic role of decongestion‐related change cardiac morphology and in particular right heart function has not been investigated comprehensively AHF patients. Methods results This prospective observational single‐centre study included consecutive patients hospitalized for treatment with reduced, mildly‐reduced or preserved left ventricular ejection fraction (LVEF). Comprehensive transthoracic echocardiography at admission discharge assessed morphology. combined...
Abstract OBJECTIVES The objective of this study was to analyse clinical characteristics, survival and adverse events patients with advanced heart failure supported using the Abbott HeartMate 3 left ventricular assist device (LVAD). METHODS We retrospectively reviewed 42 consecutive recipients implanted in our centre between 1 November 2015 31 October 2019. RESULTS Our series comprised 39 males, aged 56.7 ± 11.8 years. Eleven (26%) had preimplant INTERMACS profiles or 2. mean duration support...
The impact of multidisciplinary care on outcome after heart transplantation (HTx) remains unclear.This retrospective study investigates the primary end point 1-year all-cause mortality (ACM) and secondary mean acute cellular rejection (ACR) grade within first postoperative year.This includes a total 140 HTx recipients (median age: 53.5 years; males: 80%; donor/recipient gender mismatch: 38.3%; length in-hospital stay: 34 days; donor 41 years). Multidisciplinary was implemented in 2008, 66...
Maximal exercise capacity as measured by peak oxygen consumption (pVO2 ) in cardiopulmonary testing (CPET) of heart transplant recipients (HTR) is limited to a 50-70% level healthy age-matched controls. This study investigated the relationship between body composition and pVO2 during first decade post-transplant.Body was determined dual-energy X-ray absorptiometry (DXA) CPET 48 HTR (n = 38 males; mean age 51 ± 12 years). A total 95 assessments were acquired 1-9 years post-transplant, results...
Maximal exercise capacity after heart transplantion (HTx) is reduced to the 50-70% level of healthy controls when assessed by cardiopulmonary testing (CPET) despite normal left ventricular function donor heart. This study investigates role β1 and β2- adrenergic receptor (AR) polymorphisms for maximal orthotopic HTx.CPET measured peak VO2 as outcome parameter in HTx recipients ≥9 months ≤4 years post-transplant (n = 41; mean VO2: 57±15% predicted value). Donor hearts were genotyped β1-AR...
Abstract Background Coronary artery spasm (CAS) is an underdiagnosed disease especially in heart transplant patients, and those patients the etiology pathophysiology remain largely unknown, although it has been associated with cardiac allograft vasculopathy or graft rejection. Case presentation We report case of a heart-transplant patient whose experienced two coronary vasospasms: first before transplantation, other at one-month postoperative course complicated by primary failure. Conclusion...
Left ventricular assist devices are increasingly used to treat selected advanced heart failure patients, because of the limited number donors available for transplantation. Newer generation portend a lower complication rate, and outcomes now similar orthotopic However, despite an increase in implants last years, 25% patients develop right failure, which remains major concern. Careful preoperative function evaluation is mandatory, novel echocardiographic load-independent parameters validated...
Heart transplantation remains the most durable treatment for patients with end-stage heart failure refractory to medical treatment. Central elements of listing criteria have remained largely unchanged in last three decades whereas has significantly increased survival and reduced disease-related symptoms. It unknown whether improvement therapy changed profile candidates or affected post-transplant survival.The study investigated a total 323 transplant recipients Lausanne University Hospital...
Abstract Introduction Acute decompensated heart failure (ADHF) is associated with a high mortality and rehospitalization rate. The aim of this study was to assess whether echocardiographic markers systolic diastolic function, their changes under treatment during hospitalization for ADHF, would predict 12-months mortality. Methods Adult patients admitted our emergency department ADHF between June 2015 January 2018 were included if complete transthoracic echocardiography (TTE) could be...