Johannes T. Heverhagen

ORCID: 0000-0002-5416-6650
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About
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Research Areas
  • Advanced MRI Techniques and Applications
  • MRI in cancer diagnosis
  • Medical Imaging Techniques and Applications
  • Radiation Dose and Imaging
  • Radiomics and Machine Learning in Medical Imaging
  • Advanced X-ray and CT Imaging
  • Lanthanide and Transition Metal Complexes
  • Atomic and Subatomic Physics Research
  • Cardiac Imaging and Diagnostics
  • Liver Disease Diagnosis and Treatment
  • Lung Cancer Diagnosis and Treatment
  • Liver Disease and Transplantation
  • Ultrasound in Clinical Applications
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Cerebrovascular and Carotid Artery Diseases
  • Acute Kidney Injury Research
  • Urinary Bladder and Prostate Research
  • NMR spectroscopy and applications
  • Optical Imaging and Spectroscopy Techniques
  • Advanced Neuroimaging Techniques and Applications
  • Advanced Radiotherapy Techniques
  • Nuclear Physics and Applications
  • Radiology practices and education
  • Pelvic floor disorders treatments
  • Photoacoustic and Ultrasonic Imaging

University of Bern
2016-2025

University Hospital of Bern
2016-2025

The Ohio State University
2006-2024

Medical University of Vienna
2015-2023

Norwegian Womens Public Health Association
2023

Siemens Healthcare (United States)
2016-2021

Siemens (Germany)
2016-2019

Resonance Research (United States)
2019

Center for Innovation
2019

Bayer (United States)
2018

<h3>Objective:</h3> Familial pancreatic cancer (FPC) accounts for approximately 3% of all (PC) cases. It has been suggested that high-risk individuals (HRIs) should be offered a screening programme. <h3>Aim:</h3> To evaluate the diagnostic yield prospective programme in HRIs from families with FPC over period 5 years. <h3>Methods:</h3> National German Pancreatic Cancer Registry (FaPaCa) were counselled and enrolled prospective, board-approved PC Screening included clinical examination,...

10.1136/gut.2008.171611 article EN Gut 2009-05-25

Study Objectives:Idiopathic rapid eye movement sleep behavior disorder (iRBD)—a parasomnia characterized by dream enactments—is a risk marker for the development of Parkinson disease (PD) and other α-synucleinopathies. The pathophysiology iRBD is likely due to dysfunction brainstem nuclei that regulate REM sleep. Diffusion tensor imaging (DTI) method studying microstructural brain tissue integrity in vivo. We investigated whether DTI detects abnormalities patients with iRBD—compared...

10.1093/sleep/33.6.767 article EN SLEEP 2010-06-01

Introduction Adequate migration and differentiation of mesenchymal stem cells is essential for regeneration large bone defects. To achieve this, modern graft materials are becoming increasingly important. Among them, electrospun nanofiber scaffolds a promising approach, because their high physical porosity potential to mimic the extracellular matrix (ECM). Materials Methods The objective present study was examine impact PLLA on formation in vivo, using critical size rat calvarial defect...

10.1371/journal.pone.0025462 article EN cc-by PLoS ONE 2011-09-28

Objectives The objective of this study is to assess the performance a computer-aided diagnosis (CAD) system (INTACT system) for automatic classification high-resolution computed tomography images into 4 radiological diagnostic categories and compare with radiologists on same task. Materials Methods For comparison, total 105 cases pulmonary fibrosis were studied (54 nonspecific interstitial pneumonia 51 usual pneumonia). All diagnoses lung disease board consensus (radiologically or...

10.1097/rli.0000000000000574 article EN cc-by-nc-nd Investigative Radiology 2019-05-06

To determine the effect of use iodinated contrast agents on formation DNA double-strand breaks during chest computed tomography (CT).This study was approved by institutional review board, and written informed consent obtained from all patients. This single-center performed at a university hospital. A total 179 patients underwent material-enhanced CT, 66 unenhanced CT. Blood samples were taken these prior to immediately after In blood samples, average number phosphorylated histone H2AX...

10.1148/radiol.14132478 article EN Radiology 2015-02-05

Objectives This preclinical study was devised to investigate potential cellular toxicity in human neurons induced by gadolinium-based contrast agents (GBCAs) used for contrast-enhanced magnetic resonance imaging (MRI). Neurons modeling a subset of those the basal ganglia were tested, because region is 1 2 brain regions that displays greatest T1-dependent signal hyperintensity changes. Methods Eight GBCAs tested. Dopaminergic differentiated from an established neuroblastoma cell line and...

10.1097/rli.0000000000000567 article EN Investigative Radiology 2019-05-06

The amount of acquired radiology imaging studies grows worldwide at a rapid pace. Novel information technology tools for radiologists promise an increase reporting quality and as well quantity the same time. Automated text report drafting is one branch this development. We defined present study in total 9 cases distal radius fracture. Command files structured according to template Radiological Society North America (RSNA) Arbeitsgemeinschaft Osteosynthese (AO) classifiers were given input...

10.1067/j.cpradiol.2023.04.001 article EN cc-by Current Problems in Diagnostic Radiology 2023-04-17

Background Extracellular volume (ECV) correlates with the degree of liver fibrosis. Purpose To analyze performance MRI‐based ECV evaluations different blood pool measurements at time points. Study Type Prospective. Sample 73 consecutive patients ( n = 31 females, mean age 56 years) histopathology‐proven Field Strength/Sequence 3T acquisition within 90 days biopsy, including shortened modified look–locker inversion recovery T1 mapping. Assessment Polygonal regions interest were manually drawn...

10.1002/jmri.29259 article EN cc-by-nc-nd Journal of Magnetic Resonance Imaging 2024-03-29

Abstract Objectives This study aimed to evaluate whether minimum-intensity projection (MinIP) images could predict complications in CT-guided lung biopsies. Methods We retrospectively analyzed 72 procedures from January 2019 December 2023, categorizing patients by pneumothorax and the severity of hemorrhage (grade 2 or higher). Radiodensity measurements were performed using window (LW) MinIP (10-mm slab) images. Regions interest (ROIs) placed at sites lowest density along biopsy pathway....

10.1186/s13244-024-01890-7 article EN cc-by Insights into Imaging 2025-01-13

Abstract Background The study aimed to investigate the reduction of hematoma risk during MRI-guided breast biopsies by evaluating position-dependent intervention parameters and characteristics target lesion. Materials methods We retrospectively analyzed 252 percutaneous performed at a single center between January 2013 December 2023. Two groups were built depending on severity relative formation (using cut-off ≤ 7.62 cm 3 or &gt; ). Potential influencing variables assessed, such as patient...

10.2478/raon-2025-0004 article EN cc-by-nc-nd Radiology and Oncology 2025-01-22

Purpose: The purpose of this study was to prospectively investigate patients with suspected acute colonic diverticulitis and provide sensitivity, specificity, interobserver agreement in a blinded trial. Methods: Fifty-five (29 men; 59 ± 13 (range, 29-76) years) who reported the emergency room clinically were included study. All underwent magnetic resonance imaging scans their abdomen before after contrast agent administration. Two assessors all clinical, laboratory, radiologic results...

10.1007/s10350-008-9330-4 article EN Diseases of the Colon & Rectum 2008-04-28

This paper presents a detailed investigation into the calculation of perturbation and beam quality correction factors for ionization chambers in high-energy photon beams with use Monte Carlo simulations. For model NE2571 Farmer-type chamber, all separate as found current dosimetry protocols were calculated fixed order compared to currently available data. Furthermore, PTW31010 thimble chamber used calculate factor kQ. The calculations kQ showed good agreement published values AAPM TG-51 IAEA...

10.1088/0031-9155/53/11/005 article EN Physics in Medicine and Biology 2008-05-06

This study investigated strategies to reduce pneumothorax risk in CT-guided lung biopsy. The approach involved administering 10 ml of 1 % lidocaine fluid the subpleural or pleural space before puncture and utilizing gravitational effect pressure with specific patient positioning.

10.1016/j.ejrad.2024.111529 article EN cc-by European Journal of Radiology 2024-05-24

Abstract Purpose To investigate the use of four‐dimensional (4D) co‐occurrence‐based texture analysis to distinguish between nonmalignant and malignant tissues in dynamic contrast‐enhanced (DCE) MR images. Materials Methods 4D was performed on DCE‐MRI data sets breast lesions. A model‐free neural network‐based classification system assigned each voxel a “nonmalignant” or “malignant” label based textural features. The results were compared via receiver operating characteristic (ROC) curve...

10.1002/jmri.20837 article EN Journal of Magnetic Resonance Imaging 2007-02-05

Magnetic resonance angiography (MRA) is noninvasive and does not require the application of high doses contrast agents, thus used in clinical routine for evaluation cerebrovascular diseases, eg, aneurysm arteriovenous malformations. However, more subtle microvascular disease usually cannot be seen with resolution capabilities standard field strength MRA. The purpose this study was to evaluate ability 7-T time-of-flight (ToF) MRA depict arterial brain vasculature compare results data from 1.5...

10.1097/rli.0b013e31817e9b2c article EN Investigative Radiology 2008-07-21
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