A5005988154- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Prostate Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Atomic and Subatomic Physics Research
- Advanced NMR Techniques and Applications
- Head and Neck Surgical Oncology
- Functional Brain Connectivity Studies
- Photoacoustic and Ultrasonic Imaging
- Liver Disease Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Radiation Dose and Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Fetal and Pediatric Neurological Disorders
- Multiple Sclerosis Research Studies
- AI in cancer detection
- Cerebrovascular and Carotid Artery Diseases
- Infrared Thermography in Medicine
- Acute Ischemic Stroke Management
University of Chicago
2013-2022
Duke Medical Center
2021
Johns Hopkins University
2021
American Association of Physicists in Medicine
2021
John Wiley & Sons (United States)
2021
University of Pennsylvania
2019
The Ohio State University
2006-2018
University of Chicago Medical Center
2011-2018
University of Illinois Chicago
2013
The Ohio State University Wexner Medical Center
2008-2012
Purpose Mutations in the RET proto-oncogene and vascular endothelial growth factor receptor (VEGFR) activity are critical pathogenesis of medullary thyroid cancer (MTC). Sorafenib, a multikinase inhibitor targeting Ret VEGFR, showed antitumor preclinical studies MTC. Patients Methods In this phase II trial sorafenib patients with advanced MTC, primary end point was objective response. Secondary points included toxicity assessment response correlation tumor markers, functional imaging,...
Abstract Purpose: To evaluate the capability of amide proton transfer (APT) MR imaging for detection prostate cancer that typically shows a higher tumor cell proliferation rate and cellular density leading to an MRI‐detectable overall elevated mobile protein level in grade tumors. Materials Methods: Twelve patients with biopsy‐proven were imaged on 3 Tesla system before prostatectomy. APT‐MR images acquired by means single‐slice single‐shot turbo spin echo sequence saturation prepulse...
Purpose: To assess the early predictive power of MRI perfusion and volume parameters, during treatment cervical cancer, for primary tumor control disease-free-survival. Materials Methods: Three examinations were obtained in 101 patients before therapy (at 2–2.5 4–5 weeks) serial dynamic contrast enhanced (DCE) 3-dimensional measurement. Plateau Signal Intensity (SI) DCE curves each pixel all 3 was generated, pixel-SI distribution histograms established to characterize heterogeneous tumor....
Magnetic resonance angiography (MRA) is noninvasive and does not require the application of high doses contrast agents, thus used in clinical routine for evaluation cerebrovascular diseases, eg, aneurysm arteriovenous malformations. However, more subtle microvascular disease usually cannot be seen with resolution capabilities standard field strength MRA. The purpose this study was to evaluate ability 7-T time-of-flight (ToF) MRA depict arterial brain vasculature compare results data from 1.5...
OBJECTIVE Although frameless stereotactic techniques have become indispensable in neurosurgery, their technical complexity requires careful definition and evaluation. Navigation is of particular concern when it applied to approach a complex, tight surgical area like the temporal bone, where every millimeter important. Theoretically, bone an ideal location which use image-guided navigation because its bony construct precludes pre- intraoperative shift. In this context, feasibility using...
BACKGROUND: Several minimally invasive modifications of the standard pterional approach have been proposed recently. The lateral supraorbital is one these modifications. OBJECTIVE: To provide a qualitative and quantitative anatomic comparison surgical exposure operability afforded by approach. METHODS: Eight approaches 8 were used in fresh human cadaver heads. One 2 tools to assess exposure. RESULTS: Qualitatively, has advantages reduced trauma temporalis muscle that comparable provided...
To study the dependence of apparent diffusion coefficient (ADC) and T2 on echo time (TE) b-value, respectively, in normal prostate cancer, using two-dimensional MRI sampling, referred to as "hybrid multidimensional imaging."The included 10 patients with biopsy-proven cancer who underwent 3 Tesla MRI. Diffusion-weighted (DWI) data were acquired at b = 0, 750, 1500 s/mm(2) . For each TEs 47, 75, 100 ms. ADC measured a function b-value TE, 15 regions interest (ROIs). The Friedman test was used...
To determine the possibility of obtaining high-quality magnetic resonance (MR) images before, during, and immediately after ejaculation detecting measurable changes in quantitative MR imaging parameters ejaculation.In this prospective, institutional review board-approved, HIPAA-compliant study, eight young healthy volunteers (median age, 22.5 years), providing informed consent, underwent while masturbating to point ejaculation. A 1.5-T unit was used, with an eight-channel surface coil a...
ABSTRACT BACKGROUND AND PURPOSE Intra‐arterial recanalization postprocedural imaging in stroke patients can result diagnostic complications due to hyperdensities on noncontrast computed tomography (CT), which may represent either contrast extravasation or intracranial hemorrhage. If these lesions are hemorrhage, then they risk factors becoming symptomatic, which, if not distinguished, alter clinical management. We investigate the effects of iodinated magnetic resonance (MRI) and prevalence...
Abstract Relaxometric measurement of the effective transverse relaxation rate R plays an important role in quantitative evaluation brain function, perfusion, and tissue iron content. However, accurate is prone to macroscopic background field inhomogeneity. In clinical applications systems, postprocessing correction techniques are more flexible implementation than unsupported protocol or hardware modifications. The current approach assumes cross‐slice inhomogeneity can be approximated by a...
The purpose of this article is to study relationships between MRI-based prostate volume and volume-adjusted serum prostate-specific antigen (PSA) concentration estimates cancer Gleason score.The included 61 patients with (average age, 63.3 years; range 52-75 years) who underwent MRI before prostatectomy. A semiautomated technique was used estimate total central gland volumes, fraction (central divided by volume), PSA density (PSAD; PSAD for the (PSA volume). These were compared prostatectomy...
OBJECTIVE Hearing loss after removal of vestibular schwannomas with preservation the cochlear nerve can result from labyrinthine injury posterior semicircular canal and/or common crus during drilling wall internal auditory meatus. Indeed, there are no anatomic landmarks that intraoperatively identify position or crus. We investigated usefulness image guidance and endoscopy for exposure (IAC) its fundus without a retrosigmoid approach. METHODS A approach to IAC was performed on 10 whole fresh...
Magnetic resonance (MR) imaging of the canine brain is commonly acquired at field strengths ranging from 0.2 to 1.5 T. Our purpose was compare MR image quality 3 vs. 7 T in dogs. Low‐resolution turbo spin echo (TSE) T2‐weighted images (T2W) were obtained transverse, dorsal, and sagittal planes, high‐resolution TSE T2W proton density‐weighted transverse dorsal both Three experienced reviewers evaluated 32 predetermined structures independently without knowledge strength for spatial resolution...
Abstract Magnetic resonance‐guided focused ultrasound (MRgFUS) is a completely non‐invasive technology that has been approved by FDA to treat several diseases. This report, prepared the American Association of Physicist in Medicine (AAPM) Task Group 241, provides background on MRgFUS with focus clinical body systems. The report addresses issues interest medical physics community, specific system configuration, and recommendations how successfully implement maintain program. following...
Venous thromboembolism is a significant source of morbidity and mortality worldwide. Catheter-directed thrombolytics the primary treatment used to relieve critical obstructions, though its efficacy varies based on thrombus composition. Non-responsive portions specimen often remain in situ, which prohibits mechanistic investigation lytic resistance or development diagnostic indicators for outcomes. In this study, samples extracted from venous patients were analyzed ex vivo determine their...
Abstract One of the most powerful features dynamic contrast‐enhanced (DCE) MRI technique is its capability to quantitatively measure physiological or pathophysiological environments assessed by passage contrast agent means model‐based pharmacokinetic analysis. The widely used two‐compartment model developed Brix and colleges fits tumor data well in cases, but fails explain biexponential arterial input function. In this work, problem has been attacked from a theoretical point view, showing...