A5073948949- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Effects of Radiation Exposure
- Ocular Oncology and Treatments
- Mathematical Biology Tumor Growth
- PARP inhibition in cancer therapy
- Radiation Detection and Scintillator Technologies
- Ovarian cancer diagnosis and treatment
- Horticultural and Viticultural Research
- Nuclear Physics and Applications
- Fermentation and Sensory Analysis
- Atomic and Molecular Physics
- Management of metastatic bone disease
- X-ray Spectroscopy and Fluorescence Analysis
- Breast Cancer Treatment Studies
- Advances in Oncology and Radiotherapy
- Head and Neck Cancer Studies
- Radiation Shielding Materials Analysis
University of Southern California
2022-2024
Barrow Neurological Institute
2024
Mohamed bin Zayed University of Artificial Intelligence
2024
Shihezi University
2024
Ministry of Agriculture and Rural Affairs
2023-2024
Xinjiang Academy of Agricultural and Reclamation Science
2024
Medical Research Associates
2024
Northeastern University
2024
People's Liberation Army 401 Hospital
2024
China Agricultural University
2023-2024
The concept of spatially fractionated radiation therapy (SFRT) was conceived over 100 years ago, first in the form GRID, which has been applied to clinical practice since its early inception and continued present even with markedly improved instrumentation therapy. LATTICE (LRT) introduced 2010 as a conceptual 3D extension GRID several uniquely different features. Since 2014, when patient treated, 150 patients bulky tumors worldwide have received LRT. Through brief review basic principles...
Abstract Applications of mathematical modeling can improve outcome predictions cancer therapy. Here we present a kinetic model incorporating effects radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis volume regression data 80 cervical patients (stages 1B2-IVA) who underwent radiation Regression rates derived parameters correlated significantly with clinical (P < 0.001; median follow-up: 6.2 years). The 6-year local control rate was 87% versus 54% using...
Purpose: To assess the early predictive power of MRI perfusion and volume parameters, during treatment cervical cancer, for primary tumor control disease-free-survival. Materials Methods: Three examinations were obtained in 101 patients before therapy (at 2–2.5 4–5 weeks) serial dynamic contrast enhanced (DCE) 3-dimensional measurement. Plateau Signal Intensity (SI) DCE curves each pixel all 3 was generated, pixel-SI distribution histograms established to characterize heterogeneous tumor....
The limits of radiation tolerance, which often deter the use large doses, have been a major challenge to treatment bulky primary and metastatic cancers. A novel technique using spatial modulation megavoltage therapy beams, commonly referred as spatially fractionated (SFRT) (e.g., GRID therapy), purposefully maintains high degree dose heterogeneity across treated tumor volume, has shown promise in clinical studies method improve response advanced, tumors. Compared conventional uniform-dose...
Purpose: Dosimetric accuracy in radiation treatment of breast cancer is critical for the evaluation cosmetic outcomes and survival. It often considered that planning systems (TPS) may not be able to provide accurate dosimetry buildup region. This was investigated various techniques such as tangential wedges, field‐in‐field (FF), electronic compensator (eComp), intensity‐modulated radiotherapy (IMRT). Methods: Under Institutional Review Board (IRB) exemption, plans 111 cases were...
2002 Background: Poly (ADP-ribose) polymerase (PARP) mediates DNA damage response; niraparib is an investigational PARP1/2-selective inhibitor. This Phase 0 study evaluates newly-diagnosed glioblastoma (GBM) tumor pharmacokinetics (PK) and pharmacodynamics (PD), graduating patients with O6-methylguanine methyltransferase (MGMT) unmethylated tumors into a therapeutic regimen of plus fractionated radiotherapy when PK threshold met. Methods: Presumed GBM received 4 days (300/200 mg QD) prior to...
Immune checkpoint inhibitors (ICIs) have shown promise in treating triple-negative breast cancer (TNBC), but resistance to these therapies remains a significant challenge. AT-rich interactive domain 1A (ARID1A), component of the SWItch/Sucrose Non-Fermentable chromatin remodeling complex, is frequently mutated TNBC and associated with increased programmed cell death ligand 1 expression, which contributes immune evasion. Paradoxically, this mutation may make potentially more responsive ICIs....
The fragmentation of the CO molecule by O7+ion impact is investigated in two different energy regimes fragment ion momentum spectroscopy. improved resolution present kinetic release measurement together with application a time-dependent wavepacket dynamics method used conjunction new high-level computations large number dication potential curves enables one to unambiguously assign each line an excited state transient molecular produced during collision. This first direct experimental...
We report our experience in providing palliative radiotherapy (RT) to patients with head and neck cancers (HNCs). Our hypofractionated regimen, "0-7-21", treats 24 Gy three fractions.Patients, disease response data were retrieved for candidates of 0-7-21 from 2005 2012. Primary end points included symptom tumour size responses RT based on evaluation criteria solid tumours (RECIST) guidelines. Secondary progression-free survival (PFS) within the irradiated field, overall (OS) symptomatic PFS...
Spatially fractionated radiation therapy (SFRT), which delivers highly nonuniform dose distributions instead of conventionally practiced homogeneous tumor dose, has shown high rates clinical response with minimal toxicities in large-volume primary or metastatic malignancies. However, prospective multi-institutional trials SFRT are lacking, and techniques parameters remain variable. Agreement on prescription, technical administration, translational design for is essential to enable broad...
Depression is a common mental disorder and leading cause of disability. At its most severe, it can lead to suicide. Recently, there has been growing interest in the application natural herbs for prevention treatment depression. In this report, we found that ginsenoside active component Rg3 an apparent antidepressant effect. N-methyl-d-aspartic acid (NMDA)-treated HT22 murine hippocampal neuronal cells, recovered proliferation inhibited apoptosis by altering cell cycle. More interestingly,...
PurposeSpatially fractionated radiation therapy (SFRT) is increasingly used for bulky advanced tumors, but specifics of clinical SFRT practice remain elusive. This study aimed to determine patterns GRID and Lattice (LRT) based SFRT.Materials MethodsA survey was designed identify oncologists' patient selection SFRT, dosing/planning, dosimetric parameter use, platforms/techniques, combinations with conventional external beam (cERT) multimodality therapies, physicists' technical implementation,...
The clear juice fermentation technique for white wines suggests that grape seeds, rich in flavan-3-ols and proanthocyanidins, are not effectively utilized the winemaking process. This study incorporated 'Gewürztraminer' seeds into 'Cabernet Sauvignon' must before cold soak to investigate how resultant red wines' phenolic compound profiles, color, astringency were affected. results showed adding primarily inhibited leaching of from both skins seeds. A significant increase levels flavan-3-ols,...
Computations of heterogeneity dose parameters in GRID therapy remain challenging many treatment planning systems (TPS). To address this difficulty, we developed reference tables for a standard collimator and validate their accuracy. The .decimal Inc. was implemented within the Eclipse TPS. accuracy calculation confirmed commissioning process. Representative sets simulated ellipsoidal tumours ranging from 6-20 cm diameter at 3-cm depth; 16-cm 3, 6, 10 depth were studied. All treated with 6MV...
brachytherapy sources are being used for interstitial implants in tumor sites such as the prostate. Recently, ADVANTAGE™ Model IAI‐125, source became commercially available treatment. Dosimetric characteristics (dose rate constant, radial dose function, and anisotropy function) of this were experimentally theoretically determined, following AAPM Task Group 43 recommendations. Derivation constant was based on recent NIST WAFAC calibration performed accordance with their 1999 standard....
Purpose: To evaluate the impact of dose size in single fraction, spatially fractionated (grid) radiotherapy for selectively killing infiltrated melanoma cancer cells different tumor sizes, using radiobiological models. Methods: A Monte Carlo technique was employed to calculate 3D distribution a commercially available megavoltage grid collimator 6 MV beam. The linear‐quadratic (LQ) and modified linear quadratic (MLQ) models were used separately therapeutic outcome series fraction regimens...
The loss of red hue in dry wine has been a persistent issue for enterprises western China. We investigated the changes anthocyanins and non-anthocyanin phenols during industrial-scale fermentation one-year bottle aging Vitis vinifera L. Merlot Marselan, respectively, using grapes Ningxia region. also examined their correlation with color characterization. study found that both phenolics were rapidly extracted from alcohol fermentation. However, concentrations decreased malolactic On other...