A5024559742- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- MRI in cancer diagnosis
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Thyroid Cancer Diagnosis and Treatment
- Tuberous Sclerosis Complex Research
- Advanced MRI Techniques and Applications
- Urologic and reproductive health conditions
- Pancreatic and Hepatic Oncology Research
- Cervical Cancer and HPV Research
- Tumors and Oncological Cases
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Head and Neck Anomalies
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
University of Chicago
2016-2025
The University of Texas MD Anderson Cancer Center
2017-2024
Università Cattolica del Sacro Cuore
2024
Beth Israel Deaconess Medical Center
2024
Massachusetts General Hospital
2013-2024
University of Chicago Medical Center
2011-2023
Novartis (Switzerland)
2022
Jazz Pharmaceuticals (United States)
2022
Novocure (Jersey)
2022
Universidad Libre de Colombia
2022
To analyze the diffusion and perfusion parameters of central gland (CG) prostate cancer, stromal hyperplasia (SH), glandular (GH) to determine role these in differentiation CG cancer from benign hyperplasia.In this institutional review board-approved (with waiver informed consent), HIPAA-compliant study, 38 foci carcinoma, SH nodules, GH nodules were analyzed 49 patients (26 with carcinoma) who underwent preoperative endorectal magnetic resonance (MR) imaging radical prostatectomy. All...
Purpose To evaluate the potential utility of a number parameters obtained at T2-weighted, diffusion-weighted, and dynamic contrast material–enhanced multiparametric magnetic resonance (MR) imaging for computer-aided diagnosis (CAD) prostate cancer assessment aggressiveness. Materials Methods In this institutional review board–approved HIPAA-compliant study, MR images were acquired with an endorectal coil in 48 patients (median age, 62.5 years; age range, 44–73 years) who subsequently...
The objective of our study was to investigate whether quantitative parameters derived from diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) correlate with Gleason score angiogenesis prostate cancer.Seventy-three patients who underwent preoperative radical prostatectomy were included in study. A radiologist pathologist located the dominant tumor on MR images based histopathologic correlation. For each tumor, apparent diffusion coefficient (ADC) value DCE-MRI (i.e.,...
Background: The treatment for patients with papillary thyroid microcarcinoma (PTMC) is controversial because PTMC often found incidentally and its prognosis very good. Lymph node metastasis (LNM) one of the main predictors recurrence survival. This retrospective study aimed to identify clinical pathologic factors that increase risk or recurrence, in order isolate clinically unfavorable PTMCs help guide therapy. Methods: Clinical data were collected from 273 diagnosed at University Chicago...
Somatic mutations and copy number variation in the ERBB family are frequent urothelial carcinoma (UC) may represent viable therapeutic targets. We studied whether afatinib (an oral, irreversible inhibitor of ErbB family) has activity UC if specific molecular alterations associated with clinical response.In this phase II trial, patients metastatic platinum-refractory received 40 mg/day continuously until progression or intolerance. The primary end point was 3-month progression-free survival...
Therapy with anti-PD-L1 immune check-point inhibitors is approved for several cancers, including advanced urothelial carcinomas. PD-L1 prevalence estimates vary widely in bladder cancer, and lack of correlation between expression clinical outcomes immunotherapy response may be attributed to methodological differences the immunohistochemical reagents procedures. We characterized 235 carcinomas 79 matched pairs primary metastatic cancers using a panel four immunoassays comparison RNAscope...
Background: Thyroid-related mortality has remained constant despite the increasing incidence of thyroid carcinoma. Most nodules are benign; therefore, ultrasound and fine needle aspiration (FNA) integral in cancer screening. We hypothesize that increased nodule size at does not predict malignancy correlation between pathologic exam is good. Methods: Resected thyroids with preoperative ultrasounds were identified. Nodule ultrasound, FNA diagnosis by Bethesda category, examination, final...
Purpose To evaluate whether compartmental analysis by using hybrid multidimensional magnetic resonance (MR) imaging can be used to diagnose prostate cancer and determine its aggressiveness. Materials Methods Twenty-two patients with underwent preoperative 3.0-T MR imaging. Axial images were obtained all combinations of echo times (47, 75, 100 msec) b values 0, 750, 1500 sec/mm2, resulting in a 3 × array data associated each voxel. Volumes the tissue components stroma, epithelium, lumen...
Eosinophilic renal neoplasms have a wide spectrum of histologic presentations, and several studies demonstrated subtype cell carcinomas (RCCs) associated with the tuberous sclerosis complex (TSC)/mammalian target rapamycin pathway. A review our institutional archives led to identification 18 cases eosinophilic tumors unusual morphology. Immunohistochemical analysis that these could be separated into 3 groups: group 1 had solid architecture morphology similar chromophobe RCC but was negative...
This study demonstrates that hybrid multidimensional MRI has the potential to improve MRI/US fusion biopsy results, provide more reliable detection of prostate cancer, and add complementary information Prostate Imaging Reporting Data System–based evaluation by expert radiologists.
To retrospectively evaluate the diagnostic performance of multiparametric endorectal magnetic resonance (MR) imaging, including T2-weighted, diffusion-weighted (DW), and dynamic contrast material-enhanced (DCE) MR techniques, for diagnosis seminal vesicle invasion (SVI) to determine incremental value DW DCE images.This retrospective HIPAA-compliant study was approved by institutional review board, with a waiver informed consent. The included 131 patients (mean age, 68 years; range, 43-75...
Purpose To evaluate the performance and interobserver agreement of qualitative dynamic contrast material enhanced magnetic resonance (MR) imaging curve analysis as described in Prostate Imaging Reporting Data System (PI-RADS) for differentiation prostate cancer (PCa) from healthy prostatic tissue peripheral zone (PZ). Materials Methods This Health Insurance Portability Accountability Act–compliant institutional review board–approved retrospective included 120 consecutive pretreatment...
Abstract Purpose: Because of suboptimal outcomes in muscle-invasive bladder cancer even with multimodality therapy, determination potential genetic drivers offers the possibility improving therapeutic approaches and discovering novel prognostic indicators. Experimental Design: Using pTN staging, we case-matched 81 patients resected ≥pT2 cancers for whom perioperative chemotherapy use disease recurrence status were known. Whole-exome sequencing was conducted 43 cases to identify recurrent...
To validate three previously identified quantitative image features across multiparametric magnetic resonance (MR) images acquired with imagers made by two different manufacturers to differentiate prostate cancer (PC) from normal prostatic tissue and assess aggressiveness.This study was HIPAA-compliant approved the institutional review board. Preoperative 1.5-T endorectal MR of 119 PC patients (dataset A, 71 patients; dataset B, 48 patients) were analyzed, 265 peripheral zone regions...
The success of cancer immunotherapies has highlighted the potent ability local adaptive immune responses to eradicate cells by targeting neoantigens generated somatic alterations. However, how these factors interact drive natural history muscle-invasive bladder (MIBC) is not well understood.To investigate role regulation in MIBC disease progression, we performed massively parallel T-cell receptor (TCR) sequencing tumor-infiltrating T (TILs), silico neoantigen prediction from exome sequences,...
// Sonia Gaur 1 , Nathan Lay 2 Stephanie A. Harmon 1, 3 Sreya Doddakashi Sherif Mehralivand 4, 5 Burak Argun 6 Tristan Barrett 7 Sandra Bednarova 8 Rossanno Girometti Ercan Karaarslan 9 Ali Riza Kural Aytekin Oto 10 Andrei S. Purysko 11 Tatjana Antic 12 Cristina Magi-Galluzzi 13 Yesim Saglican 14 Stefano Sioletic 15 Anne Y. Warren 16 Leonardo Bittencourt 17 Jurgen J. Fütterer 18 Rajan T. Gupta 19 Ismail Kabakus 20 Yan Mee Law 21 Daniel Margolis 22 Haytham Shebel 23 Antonio C. Westphalen 24...
Background: Follicular thyroid carcinoma (FTC) comprises 10% of differentiated cancers. Diagnostic controversy and interobserver variability render the practical diagnosis FTC difficult. Overall survival rates vary (46–97%). The aims this study were to review histologically at authors' tertiary care institution evaluate long-term recurrence. Methods: slides from 66 cases (1965–2007) reviewed by three pathologists two institutions (blinded clinical outcomes), consensus was obtained. Patient...
Eosinophilic solid and cystic renal cell carcinomas (ESC RCC) is a rare, unique tumor type not yet included in the World Health Organization classification of neoplasia. Separately, RCCs found patients with tuberous sclerosis complex (TSC) have recently been categorized into 3 morphologic groups: RCC tubulopapillary architecture separated by smooth muscle stroma, chromophobe-like, eosinophilic-microcytic type. The third has identified ∼11% TSC-associated histology identical to ESC RCCs....
Abstract Purpose: The aberrant activity of developmental pathways in prostate cancer may provide significant insight into predicting tumor initiation and progression, as well identifying novel therapeutic targets. To this end, despite shared androgen-dependence functional similarities to the gland, seminal vesicle is exceptionally rare. Experimental Design: We conducted genomic pathway analyses comparing patient-matched normal epithelial cells identify for progression. Derived gene...
The aim of this study was to determine the accuracy diagnosis and level agreement cytologic low-grade urothelial carcinoma (LGUC) among experienced cytopathologists help development upcoming classification scheme ("The Paris System") urinary cytology (UTCy). Forty ThinPrep (Cytyc, Boxborough, MA) UTCy specimens (19 with corresponding biopsy diagnosed as LGUC 21 negative and/or cystoscopy specimens) were blindly reviewed by six from three institutions for malignancy (NM), atypical cells...
Comparison of T2-Weighted Imaging, DWI, and Dynamic Contrast-Enhanced MRI for Calculation Prostate Cancer Index Lesion Volume: Correlation With Whole-Mount PathologyChongpeng Sun1,2, Aritrick Chatterjee1, Ambereen Yousuf1, Tatjana Antic3, Scott Eggener4, Gregory S. Karczmar1 Aytekin Oto1Audio Available | Share Claim CREDIT
The purpose of this article is to investigate the effect b values on apparent diffusion coefficient (ADC) estimated from 1.5-T diffusion-weighted MRI (DWI) prostate acquired with an endorectal coil in distinguishing cancer normal-tissue regions interest (ROIs) and correlation ADC tumor Gleason score.Pretreatment DWI studies were analyzed retrospectively 51 consecutive patients either two (b=0 1000 s/mm2; n=26 patients) or five (b=0, 50, 200, 1500, 2000 n=25 values. In 45 normal...
OBJECTIVE. The objective of our study was to investigate associations between quantitative image features multiparametric MRI the prostate and PTEN expression peripheral zone cancer.
Abstract Objectives While aberrations in the VHL gene and chromosome 3p resulting clear cell renal carcinoma (CCRCC) are well established, we know that additional mutations chromatin remodeling genes PBRM1, SETD2, BRCA1-associated protein 1 (BAP1) contribute to pathogenesis some cases. Given known aggressive clinical behavior of BAP1-mutated CCRCC, sought define pathologic phenotype CCRCC. Methods We identified 14 cases molecularly proven CCRCC investigated their clinicopathologic features....