A5064206219- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Peroxisome Proliferator-Activated Receptors
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Breast Lesions and Carcinomas
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Urinary and Genital Oncology Studies
- Cancer-related molecular mechanisms research
Shimane University Hospital
2021-2024
Kōchi University
2011-2023
The University of Tokyo
2005-2023
Chikamori Hospital
1999-2023
Kochi Gakuen College
2023
Shimane University
2022
University of Tsukuba
2022
Kochi Medical School Hospital
2001-2021
National Cancer Center
1998-2020
Aichi Cancer Center
2020
Prostate cancer often relapses during androgen‐depletion therapy, even under conditions in which a drastic reduction of circulating androgens is observed. There some evidence that remain present the tissues hormone‐refractory prostate cancers (HRPC), and enzymes involved androgen steroid metabolic pathway are likely to be active HRPC cells. We previously carried out genome‐wide gene expression profile analysis clinical cells by means cDNA microarrays combination with microdissection found...
Abstract One of the most critical issues in prostate cancer clinic is emerging hormone-refractory cancers (HRPCs) and their management. Prostate usually androgen dependent responds well to ablation therapy. However, at a certain stage, they eventually acquire androgen-independent more aggressive phenotype show poor response any anticancer therapies. To characterize molecular features clinical HRPCs, we analyzed gene expression profiles 25 HRPCs 10 hormone-sensitive (HSPCs) by genome-wide...
Abstract A number of epidemiologic studies have indicated a strong association between dietary fat intake and prostate cancer development, suggesting that lipid metabolism plays some important roles in carcinogenesis its progression. In this study, through our genome-wide gene expression analysis clinical cells, we identified novel lipogenic gene, ELOVL7, coding possible long-chain fatty acid elongase, as overexpressed cells. ELOVL7 is regulated by the androgen pathway SREBP1, well other...
Abstract Cancer stem cells (CSCs) have been identified in various types of cancer; however, the mechanisms by which acquire CSC properties such as drug resistance and tumour seeding ability are not fully understood. Here, we microRNA-27b (miR-27b) a key regulator for generation side-population breast cancer that showed properties, also found anti-type II diabetes (T2D) metformin reduced this via miR-27b-mediated repression ectonucleotide pyrophosphatase/phosphodiesterase family member 1...
During the past few decades, incidence of breast cancer (BC) has been increasing rapidly in East Asia, and BC is currently most common several countries. The rising likely related to changing lifestyle environmental factors addition increase early diagnosis with awareness screening. understanding management are generally based on research data from West. However, emerging differences epidemiology tumor host biology Asian populations may be clinically relevant.A higher proportion...
Abstract Purpose: Because of suboptimal outcomes in muscle-invasive bladder cancer even with multimodality therapy, determination potential genetic drivers offers the possibility improving therapeutic approaches and discovering novel prognostic indicators. Experimental Design: Using pTN staging, we case-matched 81 patients resected ≥pT2 cancers for whom perioperative chemotherapy use disease recurrence status were known. Whole-exome sequencing was conducted 43 cases to identify recurrent...
Abstract Information regarding patients who were treated for breast cancer in 2018 was extracted from the National Clinical Database (NCD), which is run by Japanese physicians. This database continues 1975, created Breast Cancer Society (JBCS). A total of 95,620 cases registered. The demographics, clinical characteristics, pathology, surgical treatment, adjuvant chemotherapy, endocrine therapy, and radiation therapy summarized. We made comparisons with other reports to reveal characteristics...
In prostate cancer diagnosis, PSA test has greatly contributed to the early detection of cancer; however, expanding overdiagnosis and unnecessary biopsies have emerged as serious issues. To explore plasma biomarkers complementing specificity test, we developed a unique proteomic technology QUEST-MS (Quick Enrichment Small Targets for Mass Spectrometry). The method based on 96-well formatted sequential reversed-phase chromatography allowing efficient enrichment <20 kDa proteins quickly...
// Hiroyuki Inoue 1 , Taigo Kato Sope Olugbile Kenji Tamura Suyoun Chung 2 Takashi Miyamoto Yo Matsuo Ravi Salgia Yusuke Nakamura Jae-Hyun Park Department of Medicine, The University Chicago, IL 60637, USA OncoTherapy Science, Inc., Kawasaki, 213-0012, Japan Correspondence to: Nakamura, e-mail: ynakamura@bsd.uchicago.edu Keywords: small cell lung cancer, MELK, molecular target, kinase inhibitor, cancer stem Received: December 09, 2015 Accepted: January 29,...
Germline mutations in the PTEN gene, which cause Cowden syndrome, are known to be one of genetic factors for primary thyroid and breast cancers; however, found only a small subset research participants with non-syndrome cancers. In this study, we aimed identify germline variants that may related risk Genomic DNAs extracted from peripheral blood 14 WT female cancers were analyzed by whole-exome sequencing. Gene-based case-control association analysis using information 406 Europeans obtained...
Aims BCOR gene alteration is a genetic signature of rare subsets sarcomas. Most ‐associated sarcomas thus far reported are in the pediatric population, except for uterine We studied seven cases non‐uterine adult patients. Methods and results The patients were four men three women ranging from 26 to 71 years age. Three tumors, two which primarily affected kidney, showed BCOR‐CCNB3 . One tumor with ZC3H7B‐BCOR occurred chest wall, novel CIITA‐BCOR was found sinonasal tract. Two tumors lung...
Loss of heterozygosity on chromosome 11q23 is observed at high frequency in human nonsmall cell lung carcinomas (NSCLCs), suggesting the presence a tumor suppressor gene. Previous analysis DNA from 79 patients identified commonly deleted segment 5 centimorgans. Complementation was used to further localize putative Three yeast artificial (YAC) clones spanning minimal loss region were modified, and spheroplast fusion transfer them into A549 NSCLC or murine Lewis carcinoma (LLC) lines. The...
We investigated the ability of 7‐ethyl‐10‐[4‐(l‐piperidino)‐l‐piperidmo]carbonyloxycamptothecin (CPT‐11) to increase tumor radio‐response in vivo using human lung xenografts. The xenografts were treated with (1) CPT‐11 (10 mg/kg) intraperitoneally on days 1, 5 and 9, (2) single dose radiation Gy/leg) day or (3) a combination regimen both treatments which was given 1 h after first CPT‐11. DNA flow cytometry studies performed define cell cycle changes following treatment for 12 0, 0.5, 2.0 8.0...
Background/Aims Nephrotoxicity is a frequent and major limitation in cisplatin (CDDP)-based chemotherapy. 5-Aminolevulinic acid (ALA) widely distributed animal cells, it precursor of tetrapyrole compounds such as heme that fundamentally important aerobic energy metabolism. The aim this study to evaluate the protective role ALA CDDP-induced acute kidney injury (AKI). Method We used AKI rat model cultured renal tubular cells (NRK-52E). divided four groups rats: control, CDDP only, +...
The aim of the present study was to characterize infiltrated T cell clones that define tumor immune environment and are important in response treatment patients with advanced colorectal cancer (CRC). In order explore predictive biomarkers for efficacy immunochemotherapies, receptor (TCR) repertoire analysis performed using blood samples tissues obtained from CRC had been treated a combination five‑cancer peptide vaccines oxaliplatin‑based chemotherapy. TCR‑α/β complementary DNAs (cDNAs),...
Intestinal tissues of patients with Crohn's disease (CD) contain expanded populations T cells which are believed to mediate inflammation. We performed a detailed characterization these T-cell repertoires. obtained biopsies from the neoterminal ileum 12 undergoing evaluation for postoperative recurrent CD and 4 individuals normal terminal no history inflammatory bowel (controls). Samples diseased were 5 surgery stricturing or penetrating CD. Total RNA was extracted peripheral blood...
Abstract The Japanese Breast Cancer Society (JBCS) registry began data collection in 1975, and it was integrated into National Clinical Database 2012. As of 2016, the JBCS contains records 656,896 breast cancer patients from more than 1400 hospitals throughout Japan. In 2016 registration, number institutes involved 1422, total 95,870. We herein present summary annual collected 2016. analyzed demographic clinicopathologic characteristics registered various angles. Especially, we examined...
Abstract Purpose: The aim of this study is to identify novel molecular targets for development treatment or diagnostic markers prostate cancer through genome-wide cDNA microarray analysis cells purified by laser microdissection. Experimental Design and Results: Here, we identified molecule interacting with CasL-2 variants (MICAL2-PV), splicing MICAL2, showing overexpression in cells. Immunohistochemical using an antibody generated specific MICAL2-PV revealed that was expressed the cytoplasm...
Prostate cancer is usually androgen-dependent and responds well to androgen ablation therapy based on castration. However, at a certain stage some prostate cancers eventually acquire castration-resistant phenotype where they progress aggressively show very poor response any anticancer therapies. To characterize the molecular features of these clinical cancers, we previously analyzed gene expression profiles by genome-wide cDNA microarrays combined with microdissection found dozens...
The pancreatic manifestations seen in patients with von Hippel-Lindau (VHL) disease are subdivided into 2 categories: neuroendocrine tumors (NET), and cystic lesions, including simple cyst serous cystadenoma.The VHL-associated lesions generally asymptomatic do not require any treatment, unless they indistinguishable from other tumor types malignant potential.Because NET VHL non-functioning have potential, it is of clinical importance to find diagnose these as early possible.It will be...
Objectives: To investigate the feasibility of intraoperative photodynamic diagnosis (PDD) by 5‐aminolevulinic acid (ALA) for identification positive surgical margins (PSM) during retropubic radical prostatectomy (RRP) in patients with prostate cancer (PCa). Methods: Intraoperative PDD was carried out 16 pathologically confirmed PCa biopsy apex, or carrying >25% probability extraprostatic extension as defined Japan PC Table. Before operation, 1.0 g ALA given orally. During open RRP,...