A5031063057- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced X-ray and CT Imaging
- Congenital Heart Disease Studies
- Lanthanide and Transition Metal Complexes
- Infectious Aortic and Vascular Conditions
- Cerebrovascular and Carotid Artery Diseases
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Renal and Vascular Pathologies
- Medical Image Segmentation Techniques
- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- Vascular Malformations and Hemangiomas
- Intracranial Aneurysms: Treatment and Complications
- Hemodynamic Monitoring and Therapy
- Atomic and Subatomic Physics Research
University Hospital of Bern
2016-2025
University of Bern
2015-2025
Norwegian Womens Public Health Association
2023
Copenhagen University Hospital
2022
Rigshospitalet
2022
Institute for Molecular Medicine Finland
2022
Tufts Medical Center
2022
McGill University Health Centre
2022
German Cancer Research Center
2009-2020
Heidelberg University
2009-2020
Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular events underlying gliomagenesis are poorly understood. In this study, we have identified receptor tyrosine kinase Axl as a mediator glioma growth invasion. We demonstrate that its ligand Gas6 overexpressed in human cell lines is activated under baseline conditions. Furthermore, expressed at high levels malignant glioma. Inhibition signaling by overexpression...
Objectives This preclinical study was devised to investigate potential cellular toxicity in human neurons induced by gadolinium-based contrast agents (GBCAs) used for contrast-enhanced magnetic resonance imaging (MRI). Neurons modeling a subset of those the basal ganglia were tested, because region is 1 2 brain regions that displays greatest T1-dependent signal hyperintensity changes. Methods Eight GBCAs tested. Dopaminergic differentiated from an established neuroblastoma cell line and...
Exogenous magnetic resonance (MR) contrast media (CM) are used to improve detection and delineation of physiological pathologic structures. Temporary binding between CM proteins such as human serum albumin (HSA) may alter the relaxation-enhancing properties specific agents. In this study, presence strength HSA interaction with different was investigated.Three agents were chosen: Gd-DTPA, Gd-BT-DO3A, Gd-BOPTA, each which is known have a protein interaction. Samples prepared using 7...
Purpose:To present midterm results after thoracic endovascular aortic repair (TEVAR) in patients with connective tissue diseases focusing on secondary endoleak and reintervention due to disease progression. Methods:Between January 1997 2007, 167 received 241 stent-grafts. Eight (6 men; median age 48 years, range 32–67) Marfan 2 Ehlers-Danlos syndrome) treated stent-graft were retrospectively analyzed at a follow-up of 31 months (range 3–79). Surveillance included postoperative computed...
Aortic dissection is a severe pathological condition in which blood penetrates between layers of the aortic wall and creates duplicate channel – false lumen. This considerable change on morphology alters hemodynamic features dramatically and, case rupture, induces markedly high rates morbidity mortality. In this study, we establish patient-specific computational model simulate pulsatile flow within dissected aorta. The k-ω SST turbulence employed to represent finite volume method applied for...
Background: The pathophysiology of heart failure with preserved ejection fraction is not well understood, but evidence strongly suggests involvement microvascular dysfunction. We studied the myocardial oxygenation reserve as a direct marker coronary vascular function and its relation to deformation tissue characteristics by cardiovascular magnetic resonance (CMR). Methods: In dual-center case-control study, patients (>50%) healthy controls older than 50 years underwent quantitative CMR...
Background The association of epicardial adipose tissue (EAT) and its metabolic activity with atrial fibrillation (AF) is an area active investigation. Left (LA) enhancing EAT (e-EAT) at cardiac CT may be a noninvasive surrogate marker for the EAT. Purpose To determine relationship between LA e-EAT recurrence after AF ablation. Materials Methods In secondary analysis prospective registry consecutive patients (from July 2018 to December 2019) undergoing first ablation, total were segmented on...
Type-B aortic dissection (TBAD) is a disease in which tear develops the intimal layer of descending aorta forming true lumen and false (FL). Because outcomes are thought to be influenced by haemodynamic quantities such as pressure wall shear stress (WSS), their analysis via numerical simulations may provide valuable clinical insights. Major branches routinely included but minor virtually always neglected, despite being implicated TBAD progression development complications. As estimated carry...