Malakh Shrestha

ORCID: 0000-0002-8037-9430
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About
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Research Areas
  • Aortic Disease and Treatment Approaches
  • Cardiac Valve Diseases and Treatments
  • Aortic aneurysm repair treatments
  • Cardiac Structural Anomalies and Repair
  • Infective Endocarditis Diagnosis and Management
  • Cardiac and Coronary Surgery Techniques
  • Mechanical Circulatory Support Devices
  • Cardiac, Anesthesia and Surgical Outcomes
  • Congenital Heart Disease Studies
  • Infectious Aortic and Vascular Conditions
  • Cardiac Arrest and Resuscitation
  • Simulation-Based Education in Healthcare
  • Surgical Simulation and Training
  • Cardiac Imaging and Diagnostics
  • Hip and Femur Fractures
  • Fuel Cells and Related Materials
  • Renal and Vascular Pathologies
  • Cardiac Ischemia and Reperfusion
  • Cardiovascular Function and Risk Factors
  • Acute Kidney Injury Research
  • Cardiovascular Issues in Pregnancy
  • Health and Medical Research Impacts
  • Human Resource Development and Performance Evaluation
  • Medical Imaging Techniques and Applications
  • Cardiac tumors and thrombi

Medizinische Hochschule Hannover
2015-2024

Lincoln University College
2024

Mayo Clinic
2023-2024

Mayo Clinic in Arizona
2023-2024

WinnMed
2023

Marche Polytechnic University
2020

Leibniz University Hannover
2019

Active Implants (United States)
2018

Macquarie University
2015

University Hospital Cologne
2015

This report summarizes the 5-year clinical and haemodynamic data from three prospective, European multicentre trials with Perceval sutureless aortic valve. From April 2007 to August 2012, 731 consecutive patients (mean age: 78.5 years; 68.1% females; mean logistic EuroSCORE 10.9%) underwent AVR valve in 25 centres. Isolated was performed 498 (68.1%) patients. A minimally invasive approach 189 (25.9%) cases. The cumulative follow-up 729 patients-years. In isolated AVR, cross-clamp...

10.1093/ejcts/ezv040 article EN European Journal of Cardio-Thoracic Surgery 2015-03-06

Our goal was to present our 15-year experience (2001–2015) with the frozen elephant trunk (FET) technique. A total of 251 patients (82 aortic aneurysms, 96 acute dissection type A, 4 B dissections, 52 chronic 17 and 67 redo cases) underwent FET implantation either custom-made Chavan–Haverich (n = 66), Jotec E-vita 31) or Vascutek Thoraflex hybrid 154) prosthesis. The cases were assigned an early period (2001–2011) a contemporary (2012–present). Mean cardiopulmonary bypass time, cross-clamp...

10.1093/ejcts/ezx218 article EN European Journal of Cardio-Thoracic Surgery 2017-05-31

The aim of the Cavalier trial was to evaluate safety and performance Perceval sutureless aortic valve in patients undergoing replacement (AVR). We report 30-day clinical haemodynamic outcomes from largest study cohort with a valve. From February 2010 September 2013, 658 consecutive (mean age 77.8 years; 64.4% females; mean logistic EuroSCORE 10.2%) underwent AVR 25 European Centres. Isolated AVRs were performed 451 (68.5%) less invasive approach 219 (33.3%) cases. Of total, 40.0%...

10.1093/ejcts/ezv257 article EN European Journal of Cardio-Thoracic Surgery 2015-08-04

After a panel process, recommendations on the use of sutureless and rapid deployment valves in aortic valve replacement were given with special respect as an alternative to stented valves. Thirty-one international experts both sutureless, bioprostheses constituted panel. thorough literature review, evidence-based rated three-step modified Delphi approach by experts. Literature research could identify 67 clinical trials, 4 guidelines 10 systematic reviews for detailed text analysis obtain...

10.1093/ejcts/ezv369 article EN European Journal of Cardio-Thoracic Surgery 2015-10-29

The combined disease of the aortic arch and proximal descending aorta remains a surgical challenge. With 'frozen elephant technique', ascending aorta, along with arch, is replaced conventionally an endovascular stent graft placed into in antegrade manner through open thereby potentially allowing for 'single-stage' operation. purpose this study was to assess feasibility novel four-branched hybrid (Vascutek, Scotland).From April 2010 August 2011, 34 patients (25 males, age 60 ± 14 years) were...

10.1093/ejcts/ezs296 article EN European Journal of Cardio-Thoracic Surgery 2012-05-31

Since August 2001, the frozen elephant trunk (FET) technique has been used at our institution to treat degenerative or dissecting aneurysms involving aortic arch and descending aorta as a potential 'single-stage' procedure. The aim of this study was review FET experience present 10-year results.Between 2001 January 2012, 131 patients underwent implant with three different prostheses: custom-made Chavan-Haverich (n = 66), Jotec E-vita 30) Vascutek Thoraflex 35) prostheses. Concomitant...

10.1093/ejcts/ezt229 article EN European Journal of Cardio-Thoracic Surgery 2013-05-09

(1) Objective: Bacterial resistance to conventional antibiotic therapy is an increasingly significant worldwide challenge human health. The objective evaluate whether bacteriophage could complement or be a viable alternative in critical cases of bacterial infection related cardiothoracic surgery. (2) Methods: Since September 2015, eight patients with multi-drug resistant especially recalcitrant Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Klebsiella pneumoniae, and...

10.3390/antibiotics9050232 article EN cc-by Antibiotics 2020-05-05

In patients with acute aortic dissection involving the arch and descending aorta (AADA DeBakey type I), performing a total replacement frozen elephant trunk (FET) procedure for supposedly better long-term results is still controversial.From February 2004 to April 2016, 94 AADA I had an FET (80% men, age 58 ± 12 years). During early period (Group 1, 2004-10), technique was performed using non-branched grafts. Thirty-two percent (9/28) underwent concomitant valve-sparing root procedures. More...

10.1093/ejcts/ezw341 article EN European Journal of Cardio-Thoracic Surgery 2016-12-08

The incidence of embolic events and cerebral malperfusion in aortic dissection type A (AADA) must be viewed the context existence a number possible cannulation techniques. Since femoral is thought to associated with higher risk perfusion false lumen retrograde embolization, techniques establishing antegrade flow may provide better option. We describe herein our experience ascending this special patient population.Between November 1999 February 2006, 122 patients underwent operation for AADA...

10.1016/j.ejcts.2008.05.014 article EN European Journal of Cardio-Thoracic Surgery 2008-06-26

OBJECTIVEAortic valve-sparing David procedure has gained broad acceptance. However, few long-term results have been published. We present our results.

10.1016/j.ejcts.2011.04.012 article EN European Journal of Cardio-Thoracic Surgery 2011-05-01

Aortic valve replacement (AVR) in geriatric patients (>75 years) with small aortic roots is a challenge. Patient–prosthesis mismatch and the long cross-clamp time necessary for stentless valves or root enlargement are matters of concern. We compared results AVR sutureless (Sorin Perceval), against those conventional biological valves. Between April 2007 December 2012, 120 isolated AVRs were performed annulus (<22 mm) at our centre. In 70 (68 females, age 77.4 ± 5.5 years), (C group) 50 (47...

10.1093/icvts/ivt291 article EN Interactive Cardiovascular and Thoracic Surgery 2013-07-12

Acute type A aortic dissection (AADA) is a surgical emergency. In patients with arch and descending aorta (DeBakey I) involvement, performing total replacement frozen elephant trunk (FET) for supposedly better long-term results controversial. We hereby present our results. From February 2004 to August 2013, 52 acute DeBakey I received FET procedure at centre (43 males, age 59.21 ± 11.67 years). All had an intimal tear in the and/or proximal aorta. Concomitant procedures were Bentall (n = 15)...

10.1093/ejcts/ezu185 article EN European Journal of Cardio-Thoracic Surgery 2014-05-14

The combined disease of the aortic arch and descending aorta (aneurysms dissection) remains a surgical challenge. Various approaches have been used to treat this complex pathology. In two-stage operation, at first-stage is replaced through median sternotomy. Later, second-stage thoracic lateral thoracotomy. elephant trunk (ET) technique was introduced by H.G. Borst our centre in March 1982, greatly simplifying second-phase operation. We present 30-year experience. From 1982 2012, 179...

10.1093/ejcts/ezt359 article EN European Journal of Cardio-Thoracic Surgery 2013-07-19
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