Graziano Oldani
A5048728670- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- SARS-CoV-2 and COVID-19 Research
- Tissue Engineering and Regenerative Medicine
- Pancreatic and Hepatic Oncology Research
- Organ Donation and Transplantation
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Xenotransplantation and immune response
- Mitochondrial Function and Pathology
- Diet, Metabolism, and Disease
- Transplantation: Methods and Outcomes
- Birth, Development, and Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gut microbiota and health
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Vaccine Coverage and Hesitancy
Swiss HIV Cohort Study
2023-2025
University of Geneva
2015-2024
University Hospital of Zurich
2022-2024
University of British Columbia
2024
University of Zurich
2024
Vancouver General Hospital
2024
University Hospital of Geneva
2013-2023
Hôpital Beau-Séjour
2022-2023
Financial Research (Hungary)
2023
Geneva College
2012-2022
Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden vaccine-preventable infections (VPIs) among SOT recipients remains unclear.To assess incidence rate VPIs to evaluate whether at increased risk for specific compared with general population.This nationwide cohort study used data from Swiss Transplant Cohort Study on individuals who underwent May 2008 June 2019...
Importance Surgical site infections (SSIs) are one of the most common health care–associated infections. can have harmful effects in liver transplant (LT) recipients. Objective To assess incidence SSI after LT and identify risk factors associated with SSIs whether death graft loss. Design, Setting, Participants A multicenter cohort study encompassing data on performed at all Swiss centers between May 1, 2008, September 30, 2020, was conducted. Data analyses were 2023. Exposure Liver...
Abstract Background The use of assays detecting cytomegalovirus (CMV)–specific T cell–mediated immunity may individualize the duration antiviral prophylaxis after transplantation. Methods In this randomized trial, kidney and liver transplant recipients from 6 centers in Switzerland were enrolled if they CMV-seronegative with seropositive donors or CMV-seropositive receiving antithymocyte globulins. Patients to a based on immune monitoring (intervention) fixed (control). control group planned...
Abstract Background To date, studies assessing the risk of post-transplant hepatocellular carcinoma (HCC) recurrence have focused on tumour characteristics. This study investigated impact donor characteristics and graft quality HCC recurrence. Methods Using Scientific Registry Transplant Recipients patients with who received a liver transplant between 2004 2011 were included, was assessed. A multivariable competing regression model fitted, adjusting for confounders such as recipient sex,...
C57BL/6 mice are the most widely used strain of laboratory mice. Using in vivo proton Magnetic Resonance Spectroscopy (1H MRS), we have repeatedly observed an abnormal neurochemical profile brains both wild-type and genetically modified derived from C57BL/6J strain, consisting a several fold increase cerebral glutamine two decrease myo-inositol. This strikingly "phenotype" resembles that chronic liver disease or portosystemic shunting appeared to be independent transgene, origin chow was not...
There are limited contemporary data on the epidemiology and outcomes of bacteremia in solid organ transplant recipients (SOTr).Using Swiss Transplant Cohort Study registry from 2008 to 2019, we performed a retrospective nested multicenter cohort study describe SOTr during first year post-transplant.Of 4383 patients, 415 (9.5%) with 557 cases due 627 pathogens were identified. One-year incidence was 9.5%, 12.8%, 11.4%, 9.8%, 8.3%, 5.9% for all, heart, liver, lung, kidney, kidney-pancreas...
Kupffer cells represent the first line of defense against tumor in liver. Myeloid-derived suppressor (MDSC) have recently been observed liver parenchyma tumor-bearing animals. The present study investigates function MDSC subsets, and their impact on cell phenotype function. RIL-175 mouse hepatocellular carcinoma (HCC) were injected into median lobe C57BL/6 mice. Three weeks later, hosting nodule was removed, MDSCs sorted from remaining Mouse livers devoid HCC served as control. expressed...
Liver transplantation from marginal donors is associated with ischemia/reperfusion (I/R) lesions, which may increase the risk of post-transplant hepatocellular carcinoma (HCC) recurrence. Graft reperfusion prior to retrieval (as for extracorporeal membrane oxygenation--ECMO) can prevent I/R lesions. The impact on cancer recurrence was assessed a syngeneic Fischer-rat liver model.HCC cells were injected into vena porta all recipients at end an orthotopic (OLT). Control standard heart-beating,...
Livers with parenchymal abnormalities tolerate ischaemia-reperfusion (IR) injury poorly. IR is a risk factor for hepatocellular carcinoma (HCC) recurrence. This study assessed the link between liver and HCC recurrence, evaluated protective effect of ischaemic preconditioning.C57BL/6 mice were fed choline-deficient diet 6 12 weeks, or standard chow. Hepatic preconditioning achieved by clamping blood inflow. Hepa 1-6 cells inoculated through spleen. Thereafter, tumour burden, serum...
Clinical progress in the field of liver transplantation has been largely supported by animal models1,2. Since publication first orthotopic rat 1979 Kamada et al.3, this model remained gold standard despite various proposed alternative techniques4. Nevertheless, its broader use is limited steep learning curve5. In video paper, we show a simple and easy-to-establish revision Kamada's two-cuff technique. The suprahepatic vena cava anastomosis performed manually with running suture, porta...
The global obesity epidemic particularly affects women of reproductive age. Offspring obese mothers suffer from an increased risk liver disease but the molecular mechanisms involved remain unknown. We performed integrative genomic analysis datasets that investigated impact maternal on hepatic gene expression profile offspring in mice. Furthermore, we developed a murine model and studied development top dysregulated genes by quantitative real-time polymerase chain reaction (qPCR). Our data...
Abstract Background Many potential prognostic factors for predicting kidney transplantation outcomes have been identified. However, in Switzerland, no widely accepted model or risk score is being routinely used clinical practice yet. We aim to develop three prediction models the prognosis of graft survival, quality life, and function following Switzerland. Methods The (KIDMO) are developed with data from a national multi-center cohort study (Swiss Transplant Cohort Study; STCS) Swiss Organ...