A5057857690- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- Organ Donation and Transplantation
- Electrolyte and hormonal disorders
- Complement system in diseases
- Organ and Tissue Transplantation Research
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Acute Myocardial Infarction Research
- Neurological Complications and Syndromes
- Pneumocystis jirovecii pneumonia detection and treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bone health and treatments
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and Medication Impact
- Pharmacological Effects and Toxicity Studies
Kantonsspital Graubünden
2016-2025
University of Zurich
2014-2025
Swiss HIV Cohort Study
2023-2025
University Hospital of Zurich
2015-2024
University Hospital of Basel
2004-2023
Hôpital Beau-Séjour
2023
Financial Research (Hungary)
2023
Spital Thurgau (Switzerland)
2022
Institute of Oncology Research
2021
Luzerner Kantonsspital
2021
Natural antibodies are often dismissed from immunological analysis as “background,” but they may play an important role in conferring immunity against infections. In antibody-free mice infected with various viruses or Listeria monocytogenes , viral bacterial titers peripheral organs, including the kidney and brain, were 10 to 100 times greater than antibody-competent (and enhanced their susceptibility some infections), secondary lymphoid organs lower mice. Thus, natural a crucial by...
Abstract Background The burden and timeline of posttransplant infections are not comprehensively documented in the current era immunosuppression prophylaxis. Methods In this prospective study nested within Swiss Transplant Cohort Study (STCS), all clinically relevant were identified by transplant–infectious diseases physicians persons receiving solid organ transplant (SOT) between May 2008 December 2014 with ≥12 months follow-up. Results Among 3541 SOT recipients, 2761 (1612 kidney, 577...
Six patients with renal failure due to multiple myeloma (MM) received simultaneous kidney and bone marrow transplantation (BMT) from HLA-identical sibling donors following nonmyeloablative conditioning, including cyclophosphamide (CP), peritransplant antithymocyte globulin thymic irradiation. Cyclosporine (CyA) was given for approximately 2 months posttransplant, followed by donor leukocyte infusions. All six accepted their grafts long-term. Three lost detectable chimerism but off...
Norovirus infection is the most common cause of acute self-limiting gastroenteritis. Only 3 cases chronic norovirus in adult solid organ transplant recipients have been reported thus far.This case series describes 9 consecutive kidney allograft with persistent virus shedding and intermittent diarrhea for a duration 97-898 days. The follow-up includes clinical course, type immunosuppression, polymerase chain reaction norovirus. Detailed molecular analyses isolates from stool specimens over...
In Switzerland, organ procurement is well organized at the national-level but transplant outcomes have not been systematically monitored so far. Therefore, a novel project, Swiss Transplant Cohort Study (STCS), was established. The STCS prospective multicentre study, designed as dynamic cohort, which enrolls all solid recipients national level. features of are flexible patient-case system that allows capturing scenarios and collection patient-specific allograft-specific data. Beyond...
Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized cause of end-stage disease, primarily due to mutations in UMOD and MUC1. The lack clinical recognition the small size cohorts have slowed understanding ontology development diagnostic algorithms. We analyzed two registries from Europe United States define genetic characteristics ADTKD-UMOD ADTKD-MUC1 develop a practical score guide testing. Our study encompassed 726 patients 585 families with...
We conducted an open-label, prospective, randomized trial to assess the efficacy and safety of RANKL inhibition with denosumab prevent loss bone mineral density (BMD) in first year after kidney transplantation. Ninety transplant recipients were 1:1 2 weeks surgery receive (60 mg at baseline 6 months) or no treatment. After 12 months, total lumbar spine areal BMD (aBMD) increased by 4.6% (95% confidence interval [CI] 3.3–5.9%) 46 patients group decreased −0.5% CI −1.8% 0.9%) 44 control...
Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden vaccine-preventable infections (VPIs) among SOT recipients remains unclear.To assess incidence rate VPIs to evaluate whether at increased risk for specific compared with general population.This nationwide cohort study used data from Swiss Transplant Cohort Study on individuals who underwent May 2008 June 2019...
Importance Surgical site infections (SSIs) are one of the most common health care–associated infections. can have harmful effects in liver transplant (LT) recipients. Objective To assess incidence SSI after LT and identify risk factors associated with SSIs whether death graft loss. Design, Setting, Participants A multicenter cohort study encompassing data on performed at all Swiss centers between May 1, 2008, September 30, 2020, was conducted. Data analyses were 2023. Exposure Liver...
Recombinant viral or virus-like particles offer new tools for vaccine development. This study investigated hepatitis B core antigen (HBcAg) capsids and RNA phage Qβ coats as carriers of a foreign epitope to induce antibody responses in mice. HBcAg were shown T cell-independent (TI) antibodies. We found that these behave antigen-specific TI type 1 (TI-1) Ag comparable other rigidly structured viruses. When 5-aa long the pre-S1 domain surface (HBsAg) was introduced into optimal position HBc...
Listeria monocytogenes is widely used as a model to study immune responses against intracellular bacteria. It has been shown that neutrophils and macrophages play an important role restrict bacterial replication in the early phase of primary infection mice, cytokines interferon-γ (IFN-γ) tumor necrosis factor-α (TNF-α) are essential for protection. However, involved signaling pathways effector mechanisms still poorly understood. This investigated mouse strains deficient IFN-dependent...
Previous reports have indicated that both dendritic cells and macrophages the ability to induce cytotoxic T lymphocyte (CTL) helper (Th) cell responses in vivo. Dendritic process exogenous antigens conventionally for presentation on major histocompatibility complex (MHC) class II molecules. However, unconventional processing of vitro MHC I molecules is still an open question. In this study, we report a cloned line (D2SC/1) able present debris-associated viral proteins I-restricted CTL vitro....
Drug-induced interstitial nephritis can be caused by a plethora of drugs and is characterized sudden impairment renal function, mild proteinuria, sterile pyuria. For investigation the possible pathomechanism this disease, drug-specific T cells were analyzed, their function was characterized, these in vitro findings correlated to histopathologic changes that observed kidney biopsy specimens. Peripheral blood mononuclear from three patients showed proliferative response only one administered...
Antibody responses against antibodies, such as rheumatoid factors, are found in several immunopathological diseases and may play a role disease pathogenesis. Experience shows that they usually difficult to induce experimentally. Antibodies specific for immunoglobulin constant regions (anti-allotypic) or variable (anti-idiotypic) have been investigated animal models; the latter even postulated regulate antibody T cell via network-like interactions. Why how anti-antibodies induced during...
Kidney transplant rejections are classified into T-cell-mediated and antibody-mediated (AMR). C4d staining on allograft biopsies solid-phase assays to measure donor-specific alloantibodies have helped precisely define the latter. Although for acute AMRs, therapy mainly relies plasmapheresis or immunoadsorption, no studies treatment of chronic AMR available. Here, we report four kidney recipients suffering from 1 27 years posttransplant, who were treated with a combination rituximab...
S. Gianella, L. Haeberli, B. Joos, Ledergerber, R.P. Wüthrich, R. Weber, H. Kuster, P.M. Hauser, T. Fehr, N.J. Mueller. Molecular evidence of interhuman transmission in an outbreak Pneumocystis jirovecii pneumonia among renal transplant recipients.Transpl Infect Dis 2010: 12: 1–10. All rights reserved Abstract: (PCP) remains important cause morbidity and mortality immunocompromised individuals. The epidemiology pathogenesis this infection are poorly understood, the exact mode unclear. Recent...
This study evaluated the prognostic impact of pretransplant donor-specific anti-human leukocyte antigen antibodies (DSA) detected by single-antigen beads and compared three generations crossmatch (XM) tests in kidney transplantation.Thirty-seven T-cell complement-dependent cytotoxicity (CXM) negative living donor recipients with a retrospectively positive antihuman antibody screening assay were included. A bead test, flow cytometry XM, Luminex XM (LXM) performed, results correlated...
Background and objectives Definition of individual risk profile is the first step to implement strategies keep delicate balance between under- overimmunosuppression after kidney transplantation. Design, setting, participants, & measurements We used data from Efficacy Limiting Toxicity Elimination Symphony Study (1190 patients 2002 2004) model rejection infection in year External validation was performed a study population Fixed-Dose Concentration-Controlled Trial (630 2003 2006). Results...