A5058810249- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Kidney Stones and Urolithiasis Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Potassium and Related Disorders
- Ion Channels and Receptors
- Neurological Complications and Syndromes
- Congenital Diaphragmatic Hernia Studies
- Diabetes Treatment and Management
- Gout, Hyperuricemia, Uric Acid
- Inflammatory Biomarkers in Disease Prognosis
- Sphingolipid Metabolism and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Medication Adherence and Compliance
- Protein Kinase Regulation and GTPase Signaling
- Muscle and Compartmental Disorders
- Medical Imaging and Pathology Studies
- Heme Oxygenase-1 and Carbon Monoxide
- ECG Monitoring and Analysis
- Pediatric Urology and Nephrology Studies
- Frailty in Older Adults
- HIV Research and Treatment
- Plant Virus Research Studies
Cliniques Universitaires Saint-Luc
2019-2025
UCLouvain
2015-2024
University of Zurich
2020-2022
Beth Israel Deaconess Medical Center
2022
Grand Charleroi Hospital
2021
Directorate-General Joint Research Centre
2019
Clinique Saint Pierre
2018
Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized cause of end-stage disease, primarily due to mutations in UMOD and MUC1. The lack clinical recognition the small size cohorts have slowed understanding ontology development diagnostic algorithms. We analyzed two registries from Europe United States define genetic characteristics ADTKD-UMOD ADTKD-MUC1 develop a practical score guide testing. Our study encompassed 726 patients 585 families with...
The kidney-specific gene UMOD encodes for uromodulin, the most abundant protein excreted in normal urine. Rare large-effect variants cause autosomal dominant tubulointerstitial kidney disease (ADTKD), while common low-impact strongly associate with function and risk of chronic (CKD) general population. It is unknown whether intermediate-effect contribute to CKD. Here, candidate were identified using large-population ADTKD cohorts. Biological phenotypical effects investigated cell models,...
Abstract Background The severity of coronavirus disease 2019 (COVID-19) is highly variable between individuals, ranging from asymptomatic infection to critical with acute respiratory distress syndrome requiring mechanical ventilation. Such variability stresses the need for novel biomarkers associated outcome. As SARS-CoV-2 causes a kidney proximal tubule dysfunction urinary loss uric acid, we hypothesized that low serum levels acid (hypouricemia) may be and outcome COVID-19. Methods In...
In recent years, the strategy of using laser microdissection and mass spectrometry (LCM/MS) has expanded landscape antigens associated with membranous nephropathy (MN). Specific associations phenotypes, diseases sometimes reversible triggers led to an antigen-based classification MN, informing precision medicine highlighting for potential value routine use proteomics in classifying MN. This study aimed at reproducing further improving original LCM/MS antigen detection Retrospective cohort...
Coronavirus disease 2019 , which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly life threatening in patients who are immunocompromised, including those with advanced chronic kidney (CKD) [1,2].Despite the implementation of a third dose messenger RNA (mRNA) vaccine, efficacy SARS-CoV-2 vaccination on humoral and cellular immunities reduced population CKD, resulting an increased incidence infection mortality, fully vaccinated [3].In this context,...
Increased plasma osmolarity induces intracellular water depletion and cell shrinkage (CS) followed by activation of a regulatory volume increase (RVI). In skeletal muscle, the hyperosmotic shock-induced CS is accompanied small membrane depolarization responsible for release Ca(2+) from pools. Hyperosmotic shock also phosphorylation STE20/SPS1-related proline/alanine-rich kinase (SPAK). TRPV2 dominant negative expressing fibres challenged with present slower depolarization, diminished...
Incretin-based therapies are widely used to treat type 2 diabetes. Although hypoglycemic actions of incretins mostly due their insulinotropic/glucagonostatic effects, they may also influence extrapancreatic metabolism. We administered exendin-4 (Ex-4), a long-acting glucagon-like peptide receptor agonist, at low dose (0.1 nmol/kg/day) for short period (10 days), in obese nondiabetic fa/fa Zucker rats (ZFRs). Ex-4-treated ZFRs were compared vehicle (saline)-treated and vehicle- lean (LRs)....
Progressive multifocal leukoencephalopathy (PML) may develop in follicular lymphoma patients treated with bendamustine-rituximab. In this report, treatment pembrolizumab successfully inhibited the clinical progression of PML by promoting radiologically demonstrated immune restoration inflammatory syndrome (IRIS), allowing complete clearance virus. These findings further support use special consideration for potential occurrence IRIS.
A woman in her 40s with kidney failure secondary to biopsy-proven dense deposit disease (DDD) positive C3 nephritic factor (C3Nef) and no complement gene defect received a transplant from deceased donor. Eighteen years after transplantation, laboratory workup revealed new-onset microscopic hematuria, 547 red blood cells/μL (normal <25), proteinuria, urine protein-to-creatinine ratio of 1.0 g/g creatinine <0.150), increasing 7.5 within few months. Glomerular filtration rate, estimated...
Herniation of the liver through anterior abdominal wall is an extremely rare phenomenon. Most cases occur within incisional hernia (mostly upper abdomen surgery or cardiac surgery). Only two reports mentioned herniation without previous incision. Case Presentation. We report case a 70-year-old woman presenting epigastric swelling. Radiological findings showed in primary ventral hernia. This first to have been described requiring semiurgent repair associated with partial resection.This is,...
Abstract The kidney-specific gene UMOD encodes for uromodulin, the most abundant protein excreted in normal urine. Rare, large-effect variants cause autosomal dominant tubulointerstitial kidney disease (ADTKD) while common, low-effect strongly associate with function and risk of chronic (CKD) general population. It is unknown whether intermediate-effect contribute to CKD. Here, candidate were identified using large population ADTKD cohorts. Biological phenotypical effects investigated cell...