A5057167434- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Polyomavirus and related diseases
- Ultrasound Imaging and Elastography
- Salivary Gland Disorders and Functions
- Spinal Cord Injury Research
- Neurological Complications and Syndromes
- Moyamoya disease diagnosis and treatment
- Cytokine Signaling Pathways and Interactions
- Spinal Dysraphism and Malformations
- Plant Virus Research Studies
- Viral-associated cancers and disorders
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Peripheral Neuropathies and Disorders
- Cervical and Thoracic Myelopathy
- RNA Research and Splicing
- Neurological and metabolic disorders
- Lanthanide and Transition Metal Complexes
University of British Columbia
2019-2022
UCLouvain
2021
Europe Hospitals
2020
Cliniques Universitaires Saint-Luc
2020
Cognitive impairment is a core symptom in multiple sclerosis (MS). Damage to normal appearing white matter (NAWM) likely involved. We sought determine if greater myelin heterogeneity NAWM associated with decreased cognitive performance MS.A total of 27 participants MS and 13 controls matched for age, sex, education underwent water imaging (MWI) from which the fraction (MWF) was calculated. Corpus callosum, superior longitudinal fasciculus, cingulum were chosen as regions interest (ROIs)...
<h3>Importance</h3> Cognitive impairment is a debilitating symptom of multiple sclerosis (MS) that affects up to 70% patients. An improved understanding the underlying pathology MS-related cognitive would provide considerable benefit patients and clinicians. <h3>Objective</h3> To determine whether there an association between myelin damage in tissue appears completely normal on standard clinical imaging, but can be detected by water imaging (MWI), with performance MS. <h3>Design, Setting,...
Introduction: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease is a recently described central nervous system (CNS) inflammatory disorder with phenotypic overlap Neuromyelitis Optica Spectrum Disorder (NMOSD). NMOSD seronegative patients, and those limited forms of the disorder, become suspects for MOG disease. We describe multi-ethnic population antibody seropositivity from University British Columbia MS/NMO clinic. Methods: AQP4-antibody patients presenting 2005–2016...
Background: Myelin water imaging (MWI) was recently optimized to provide quantitative in vivo measurement of spinal cord myelin, which is critically involved multiple sclerosis (MS) disability. Objective: To assess cervical myelin measurements relapsing-remitting (RRMS) and progressive (ProgMS) participants evaluate the correlation between measures clinical Methods: We used MWI data from 35 RRMS, 30 ProgMS, 28 healthy control (HC) collected at level C2/C3 on a 3 T magnetic resonance (MRI)...
The objective of this paper is to evaluate potential dose-dependent adverse effects gadolinium-based contrast agents (GBCAs) on MS progression.Outcomes from a cohort 612 secondary progressive (SPMS) patients, enrolled in two-year, placebo-controlled (negative) trial assessing the efficacy MBP8298, were acquired. Patients received one four (infrequent cohort; IFR) or 5-11 (frequent FR) GBCA injections between week 4 and 104. primary outcome was change Expanded Disability Status Scale (EDSS)...
Spinal cord atrophy provides a clinically relevant metric for monitoring MS. However, the spinal is imaged far less frequently than brain due to artefacts and acquisition time, whereas MRI of routinely performed.To validate cross-sectional area measurements from routine 3DT1 whole-brain versus those dedicated in healthy controls people with MS.We calculated at C1 C2/3 using T2*-weighted images images, 28 73 Correlations both groups were assessed between: (1) images; (2) cord; (3) cord.C1...
Progressive multifocal leukoencephalopathy (PML) may develop in follicular lymphoma patients treated with bendamustine-rituximab. In this report, treatment pembrolizumab successfully inhibited the clinical progression of PML by promoting radiologically demonstrated immune restoration inflammatory syndrome (IRIS), allowing complete clearance virus. These findings further support use special consideration for potential occurrence IRIS.
Abstract Background and Purpose Conventional MRI measures of multiple sclerosis (MS) disease severity, such as lesion volume brain atrophy, do not provide information about microstructural tissue changes, which may be driving physical cognitive progression. Myelin damage in normal‐appearing white matter (NAWM) is likely an important contributor to MS disability. water fraction (MWF) provides quantitative measurements myelin. Mean MWF reflects average myelin content, while standard deviation...