A5012087557- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Ultrasound Imaging and Elastography
- RNA regulation and disease
- Advanced NMR Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Systemic Lupus Erythematosus Research
- MRI in cancer diagnosis
- Atomic and Subatomic Physics Research
- Bone and Joint Diseases
- Peripheral Neuropathies and Disorders
- Electron Spin Resonance Studies
- Medical Imaging and Analysis
- Mycobacterium research and diagnosis
- Rheumatoid Arthritis Research and Therapies
- Photoacoustic and Ultrasonic Imaging
- Functional Brain Connectivity Studies
- NMR spectroscopy and applications
- Radiomics and Machine Learning in Medical Imaging
- Neurological disorders and treatments
- Brain Tumor Detection and Classification
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neonatal and fetal brain pathology
University of British Columbia
2016-2025
International Collaboration On Repair Discoveries
2018-2025
Korle Bu Teaching Hospital
2024
University of British Columbia Hospital
2007-2020
St. Michael's Hospital
2019
Harvard University
2019
University of Southern California
2019
Johns Hopkins University
2019
Massachusetts General Hospital
2019
Philips (Germany)
2017
Abstract Quantitative myelin content imaging provides novel and pertinent information related to underlying pathogenetic mechanisms of myelin‐related disease or disorders arising from aberrant connectivity. Multicomponent driven equilibrium single pulse observation T 1 2 is a time‐efficient multicomponent relaxation analysis technique that estimates the water fraction, surrogate measure volume. Unfortunately, relies on two water‐pool model (myelin‐associated intra/extracellular water), which...
Abstract Myelin water imaging is a quantitative neuroimaging technique that provides the myelin fraction (MWF), metric highly specific to content, and intra-/extra-cellular T 2 (IET2), which related iron content. We coupled high-resolution data from 100 adults with gold-standard methodology create an optimized anatomical brain template accompanying MWF IET2 atlases. then used atlas characterize how content relates demographic factors. In most regions, followed quadratic pattern of increase...
Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health evaluating interventional in public studies, including those that may impact neurodevelopment. While growth generally reflects overall nutritional status, it lacks sensitivity specificity to brain developing cognitive skills abilities. Psychometric tools, e.g., Bayley Scales Infant Toddler Development, afford more direct assessment development but they require language...
Myelin imaging is a form of quantitative magnetic resonance (MRI) that measures myelin content and can potentially allow demyelinating diseases such as multiple sclerosis (MS) to be detected earlier. Although focal lesions are the most visible signs MS pathology on conventional MRI, it has been shown even tissues appear normal may exhibit decreased revealed by myelin-specific images (i.e., maps). Current methods for analyzing maps typically use global or regional mean measurements detect...
Purpose Myelin water fraction is conventionally measured from the T 2 decay curve. Recently, a steady‐state approach entitled multicomponent‐driven equilibrium single pulse observation of 1 /T (mcDESPOT) was employed for myelin mapping. However, no direct comparison between established multiecho relaxation method and mcDESPOT has been performed. Methods Gradient spin echo (GRASE) acquired curve measurements were 10 healthy volunteers using 3T MRI. We compared fraction, transmit radio...
Impact-related mild traumatic brain injuries (mTBI) are a major public health concern, and remain as one of the most poorly understood in field neuroscience. Currently, diagnosis management such based largely on patient-reported symptoms. An improved understanding underlying pathophysiology mTBI is urgently needed order to develop better diagnostic protocols. Specifically, dynamic post-injury changes myelin sheath human have not been examined, despite 'compromised white matter integrity'...
Purpose Multicomponent driven equilibrium single pulse observation of T 1 and 2 (mcDESPOT) is an alternative to established multiecho ‐based approaches for quantifying myelin water fraction, affording increased volumetric coverage spatial resolution. A concern with mcDESPOT, however, the large number model parameters that must be estimated, which may lead nonunique solutions sensitivity fitting constraints. Here we explore mcDESPOT performance under different experimental conditions better...
Abstract Quantitative magnetic resonance imaging (MRI) techniques have been developed as biomarkers, aiming to improve the specificity of MRI underlying pathology compared conventional weighted MRI. For assessing integrity white matter (WM), myelin, in particular, several proposed and investigated individually. However, comparisons between these methods are lacking. In this study, we four established myelin‐sensitive 56 patients with relapsing–remitting multiple sclerosis (MS) 38 healthy...
Enhanced prediction of progression in secondary progressive multiple sclerosis (SPMS) could improve clinical trial design. Machine learning (ML) algorithms are methods for training predictive models with minimal human intervention.To evaluate individual and ensemble model performance built using decision tree (DT)-based compared to logistic regression (LR) support vector machines (SVMs) predicting SPMS disability progression.SPMS participants (n = 485) enrolled a 2-year placebo-controlled...
Abstract In a companion paper by Cohen-Adad et al . we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This was used to acquire single subject dataset across 19 centers multi-subject 42 (for total of 260 participants), spanning three main manufacturers: GE, Philips Siemens. Both datasets are publicly available via git-annex. Data were analysed using Spinal Cord Toolbox produce...
<h3>BACKGROUND AND PURPOSE:</h3> On clinical MR images, the subthalamic nuclei (STN) are poorly delineated from adjacent structures, impeding safe direct targeting for placement of electrodes in treatment Parkinson disease. Susceptibility-weighted phase imaging offers improved contrast and spatial resolution at reduced times relative to clinically used T2-weighted spin-echo STN visualization. Our purpose was assess visibility by using imaging, comparing magnitude images obtained concurrently...
Abstract Multicomponent T 2 relaxation imaging can be used to measure signal from water trapped between myelin bilayers; the ratio of total is termed fraction (MWF). The goal this study was implement and develop single‐slice ‐imaging technique proposed by Poon Henkelman. For refinement, scan parameters (gradient crusher height slew rate, bandwidth, echo spacing, matrix size, repetition time, phase rewinding) were varied in water‐based phantoms fixed vivo brain. Changes standard deviation...
Primary lateral sclerosis (PLS) has been regarded as a rare, extreme form of amyotrophic (ALS). Like ALS, it is clinical diagnosis without established biomarkers. We sought to explore loss cerebral myelin in relation features, including cognitive impairment, cases both ALS and PLS. A novel MRI sequence (mcDESPOT) sensitive water pools within intra- extra-cellular spaces was applied 23 patients, seven PLS patients 12 healthy controls, with interval follow-up 15 four patients. Results...
Multiple sclerosis (MS) is a neurological disease with an early course that characterised by attacks of clinical worsening, separated variable periods remission. The ability to predict the risk in given time frame can be used identify patients who are likely benefit from more proactive treatment. We aim determine whether deep learning extract latent MS lesion features that, when combined user-defined radiological and measurements, conversion (defined criteria include new T2 lesions, T1...
To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques.Somatosensory evoked potentials (SSEPs) MWI were acquired 14 patients with CSM 18 age-matched healthy controls. was performed on a 3.0T whole body magnetic resonance scanner. Myelin fraction (MWF) extracted for dorsal columns cord. SSEPs MWF also compared conventional MRI outcomes, including T2 signal intensity, compression ratio, maximum spinal...
Inflammatory demyelinating lesions of the central nervous system are a common feature both neuromyelitis optica and multiple sclerosis. Despite this similarity, it is evident clinically that accumulation disability in patients with relapse related progressive phase very uncommon. This poses question whether there any pathological evidence disease activity or neurodegeneration between relapses. To investigate we conducted longitudinal advanced MRI study brain spinal cord patients, comparing...